NCT03362515

Treatment of Post-Operative Sinonasal Polyposis With Topical Furosemide

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Thomas Jefferson University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Prior studies have suggested that topical furosemide may reduce the recurrence of sinonasal polyposis following sinus surgery. This project aims to further investigate that claim through a blinded randomized controlled clinical trial following patients who undergo functional sinus surgery for chronic rhinosinusitis with sinonasal polyposis by randomly assigning participants to receive topical furosemide versus placebo nasal spray for 2 months post operatively. Outcomes would be compared at 6 months through endoscopic grading scores using Lund Kennedy and Meltzer scores as well as Sino-Nasal Outcome Test (SNOT-22) scores to measure the rate and degree of recurrence and impact on symptoms in the treatment group versus placebo.

Conditions

• Nasal Polyps

Interventions

Type	Name	Description
DRUG	Furosemide	furosemide
DRUG	Placebo	placebo

Timeline

• Start date: 2017-12-01
• Primary completion: 2022-04-14
• Completion: 2022-04-14
• First posted: 2017-12-05
• Last updated: 2023-08-30
• Results posted: 2023-08-30

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study