Clinical Trials Directory

Trials / Conditions / Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy

157 registered clinical trials studyying Hypertrophic Cardiomyopathy28 currently recruiting.

StatusTrialSponsorPhase
RecruitingA Study to Assess the Real-World Effectiveness of Mavacamten in Adult Patients With Obstructive Hypertrophic C
NCT07361289
Bristol-Myers Squibb
TerminatedEffect of Personalized Accelerated Pacing in Symptomatic Patients With Non-Obstructive Hypertrophic Cardiomyop
NCT06775886
Montefiore Medical CenterN/A
RecruitingA Clinical Study to Evaluate the Long-term Safety of HRS-1893 in Hypertrophic Cardiomyopathy
NCT07021963
Shandong Suncadia Medicine Co., Ltd.Phase 2
CompletedA Trial of HRS-1893 in Healthy Volunteers
NCT07033455
Atridia Pty Ltd.EARLY_Phase 1
RecruitingVIZ ACCESS HCM - Multi-Site Registry
NCT07103057
Viz.ai, Inc.
Not Yet RecruitingEvaluation of the Efficacy and Safety of Wearable ECG (AT-Patch) in Patients With Hypertrophic Cardiomyopathy
NCT06873828
Yonsei UniversityPhase 3
CompletedSafety and Pharmacokinetics Study of HRS-1893 Tablets in Healthy Subjects and Those With Impaired Kidney Funct
NCT06775834
Shandong Suncadia Medicine Co., Ltd.Phase 1
TerminatedNHLBI SESAME (SEptal Scoring Along Midline Endocardium) Early Feasibility Study
NCT06269640
National Heart, Lung, and Blood Institute (NHLBI)N/A
RecruitingComparison of the Effects of Inspiratory Muscle Training and Baduanjin Exercises in Hypertrophic Cardiomyopath
NCT06490250
Istanbul University - CerrahpasaN/A
RecruitingInstitutional Registry of Rare Diseases
NCT06573723
Hospital Italiano de Buenos Aires
Enrolling By InvitationHypertrophic Cardiomyopathy Federated Learning Implementation Platform
NCT06461468
American Heart Association
Active Not RecruitingA Study of Artificial Intelligence ECG With ECG Devices to Detect Hypertrophic Cardiomyopathy Distinct From At
NCT06290570
Mayo Clinic
RecruitingAssessment of Cardiac Function, Microvascular Function and Cardiac Perfusion in Different Disease Stages of Hy
NCT06400524
Amsterdam UMC, location VUmc
Active Not RecruitingA Retrospective Cohort Study of Mavacamten Patient Support Program in Canada
NCT06549608
Bristol-Myers Squibb
Active Not RecruitingA Study of EDG-7500 in Adults With Hypertrophic Cardiomyopathy (CIRRUS-HCM)
NCT06347159
Edgewise Therapeutics, Inc.Phase 2
UnknownEchocardiography-guided Percutaneous Septal Radiofrequency Ablation for Obstructive HCM After Alcohol Septal A
NCT06496633
Xijing Hospital
RecruitingAustrian Hypertrophic Cardiomyopathy Registry
NCT06368518
Medical University of Graz
UnknownA Trial of HS-10511 in Healthy Subjects
NCT06210607
Jiangsu Hansoh Pharmaceutical Co., Ltd.Phase 1
CompletedPilot Study of Hypertrophic Cardiomyopathy & Implantable Cardioverter Defibrillator Assessment: (Subcutaneous
NCT05938283
Barts & The London NHS TrustN/A
UnknownDiagnosis of HCM With AI-ECG
NCT06287892
Shanghai Zhongshan Hospital
CompletedA Study to Assess Health-Related Quality of Life in Patients With Hypertrophic Cardiomyopathy in Japan
NCT06181617
Bristol-Myers Squibb
RecruitingMavacamten Pregnancy Surveillance Program
NCT05939700
Bristol-Myers Squibb
UnknownScreening Patients With Fabry Disease in Patients With Hypertrophic Cardiomyopathy or Left Ventricular Hypertr
NCT06169358
Qilu Hospital of Shandong University
UnknownImpact of Liwen Procedure in Obstructive Hypertrophic Cardiomyopathy on Arrhythmias
NCT06031519
Xijing Hospital
RecruitingMulti-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symp
NCT05836259
Tenaya TherapeuticsPhase 1 / Phase 2
UnknownMachine Learning Approach Based on Echocardiographic Data to Improve Prediction of Cardiovascular Events in Hy
NCT06256913
Pr. Nicolas GIRERD
RecruitingCardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transitio
NCT06409585
University of Edinburgh
RecruitingCardiovascular Multimodality Imaging Study
NCT06610019
Montefiore Medical Center
RecruitingThe SMARTER Cardiomyopathy Study
NCT05750147
Imperial College London
RecruitingExercise Intolerance in Non-obstructive Hypertrophic Cardiomyopathy
NCT05818605
University of California, San FranciscoN/A
RecruitingTaiwan Registry of Hypertrophic Cardiomyopathy (THIC) Research Synopsis
NCT06381778
Far Eastern Memorial Hospital
UnknownRenal Denervation in Hypertrophic Cardiomyopathy
NCT05577208
Adolfo FontenlaN/A
RecruitingUse of SGLT2i in noHCM With HFpEF
NCT06401343
China National Center for Cardiovascular DiseasesPhase 4
UnknownAssociation of Obesity and Cardiovascular Outcomes in Hypertrophic Cardiomyopathy
NCT05645939
Ajou University School of Medicine
Active Not RecruitingEmpagliflozin in Hypertrophic Cardiomyopathy
NCT05182658
National Institute of Cardiology, Warsaw, PolandPhase 3
UnknownExercise Oxygen Kinetic and Cardiac Output in Hypertrophic Cardiomyopathy
NCT05754489
Centro Cardiologico Monzino
CompletedAnesthetic Management for TA-BSM in HOCM
NCT06397092
Tongji Hospital
Active Not RecruitingElectromechanically Optimised Right Ventricular Pacing In Hypertrophic Cardiomyopathy (EMORI-HCM)
NCT05257772
Imperial College LondonN/A
CompletedViz HCM (ECG Assist) Utilization Workflow Pilot
NCT06600256
Viz.ai, Inc.
WithdrawnComparison of Squat-to-Stand Maneuver With Amyl Nitrite, Valsalva, and Exercise Stress Echocardiography in Ind
NCT04905173
Mayo ClinicN/A
CompletedStudy Evaluating the Pharmacokinetics of Mavacamten in Healthy Adult Chinese Subjects
NCT05135871
LianBio LLCPhase 1
RecruitingSurgical Septal Myectomy vs Percutaneous Transluminal Alcohol Septal Ablation in Patients With Hypertrophic Ob
NCT04684290
St. Antonius HospitalN/A
TerminatedPaced Dyssynchrony and Myocardial Perfusion IN apiCal Hcm
NCT04231032
Barts & The London NHS TrustN/A
RecruitingStress Echo 2030: the Novel ABCDE-(FGLPR) Protocol to Define the Future of Imaging
NCT05081115
Fatebenefratelli Hospital
Enrolling By InvitationHypertrophic Cardiomyopathy Registry, Biobank and Imaging Data Repository
NCT05100420
Montreal Heart Institute
CompletedHealthy-related Quality of Life and Physical Activity of Children With Cardiac Malformations
NCT04712136
University Hospital, MontpellierN/A
UnknownRole of Perhexiline in Hypertrophic Cardiomyopathy
NCT04426578
Flinders UniversityPhase 2
CompletedThe Efficacy and Mechanism of Trientine in Patients With Hypertrophic Cardiomyopathy
NCT04706429
Manchester University NHS Foundation TrustPhase 2
CompletedIntraventricular Stasis In Cardiovascular Disease
NCT04649034
Hospital General Universitario Gregorio Marañon
RecruitingOptimisation of Decision Making for Defibrillator Implantation in Hypertrophic Cardiomyopathy
NCT03846297
Assistance Publique - Hôpitaux de Paris
WithdrawnOPIE in the Thin Interventricular Septum
NCT04050579
NYU Langone HealthN/A
Completed4D-flow MRI to Assess Left Ventricular Obstruction in Hypertrophic Cardiomyopathy
NCT04439942
Centre Hospitalier Universitaire, Amiens
CompletedPhysical Activity in Children With Inherited Cardiac Diseases
NCT04650009
University Hospital, Montpellier
CompletedEffect of Metoprolol in Post Alcohol Septal Ablation Patients With Hypertrophic Cardiomyopathy
NCT04133532
University Hospital, MotolPhase 4
CompletedExtended ECG Monitoring in HCM Patients
NCT04056715
iRhythm Technologies, Inc.
CompletedNon-Invasive Radiation Ablation in Patients With Hypertrophic CardioMyopathy: NIRA-HOCM
NCT04153162
Barts & The London NHS TrustN/A
RecruitingA 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease
NCT04464655
McGill University Health Centre/Research Institute of the McGill University Health Centre
Active Not RecruitingProspective Evaluation Of Exercise-Induced Cardiac Conduction Instability In Predicting Ventricular Fibrillati
NCT04157205
Imperial College LondonN/A
Active Not RecruitingA Prospective Incident Study of Arrhythmias in Hypertrophic Cardiomyopathy
NCT04112290
Mayo Clinic
CompletedAssessment of the Relations Between Endothelial and Venous Dysfunctions and Left Ventricular Obstruction in Ge
NCT04129905
University Hospital, BordeauxN/A
UnknownHCM-AF Ablation With ACUTUS
NCT04090437
Royal Brompton & Harefield NHS Foundation TrustN/A
CompletedCVD Risk Profile in Children With HCM
NCT05510180
University of Alberta
CompletedSacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy
NCT03832660
Newcastle UniversityPhase 2
CompletedLifestyle and Pharmacological Interventions in Hypertrophic Cardiomyopathy
NCT05366101
Newcastle-upon-Tyne Hospitals NHS TrustPhase 2 / Phase 3
CompletedIncidence of Hypertrophic Cardiomyopathy in Infants of Diabetic Mothers Attending in NICU at Assiut University
NCT06048562
Assiut UniversityN/A
Completed3D Non-invasive Myocardial Electrical Propagation Mapping as a New Tool to Predict Sudden Death Risk in Patien
NCT03550573
Hospices Civils de LyonN/A
UnknownEfficacy of Psychotherapy for Improving Quality of Life in Patients With Hypertrophic Cardiomyopathy and Depre
NCT03706001
Xijing HospitalN/A
CompletedA Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM
NCT03723655
Bristol-Myers SquibbPhase 2 / Phase 3
CompletedWill Elevated Left Ventricle Filling Pressures Decrease by a Group Exercise Program in Patients With Hypertrop
NCT03537183
Bispebjerg HospitalN/A
CompletedGenomic Sequencing in Patients With HCM Undergoing Septal Myectomy
NCT03043209
The Cleveland Clinic
CompletedManganese-Enhanced Magnetic Resonance Imaging of the Myocardium
NCT03607669
University of Edinburgh
Enrolling By InvitationSahlgrenska Cardiomyopathy Project
NCT03527342
Göteborg University
UnknownEvaluating the Effect of Spironolactone on Hypertrophic Cardiomyopathy
NCT02948998
Xinhua Hospital, Shanghai Jiao Tong University School of MedicinePhase 4
CompletedThe Effect of Metoprolol in Patients With Hypertrophic Obstructive Cardiomyopathy.
NCT03532802
Steen Hvitfeldt PoulsenPhase 2
CompletedExtension Study of Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Pre
NCT03496168
Bristol-Myers SquibbPhase 2
CompletedHigh Intensity Exercise for Increasing Fitness in Patients With Hypertrophic Cardiomyopathy
NCT03335332
University of Texas Southwestern Medical CenterN/A
CompletedExercise Training in Hypertrophic Cardiomyopathy: (SAFE-HCM)
NCT05459467
St George's, University of LondonN/A
CompletedCorrelation Between Myocardial Deformation and Coronary Artery Tortuosity in Patients With Hypertrophic Cardio
NCT04830787
Henan Provincial People's Hospital
CompletedSleep Apnea and Hypertrophic Cardiomyopathy (HCM)
NCT03327623
Mayo Clinic
TerminatedMicrovascular Dysfunction in Nonischemic Cardiomyopathy: Insights From CMR Assessment of Coronary Flow Reserve
NCT03249272
Duke UniversityPhase 4
UnknownInsertable Cardiac Monitors in Hypertrophic Cardiomyopathy
NCT03259113
Region GävleborgN/A
CompletedDifferentiation HHD From HCM (EARLY-MYO-HHD)
NCT03271385
RenJi Hospital
UnknownPresentations of Hypertrophic Cardiomyopathy on Myocardial Perfusion Imaging
NCT03150342
Far Eastern Memorial Hospital
UnknownRisk Stratification Using PET in HCM
NCT03278457
Region Gävleborg
CompletedFunctional Capacity and Quality of Life Following Septal Myectomy in Patients With HCM
NCT03092843
The Cleveland Clinic
CompletedEvaluating Microvascular Dysfunction in Symptomatic Patients With HypertroPhic CaRdiomyopathy
NCT02994615
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Active Not RecruitingPrognostic Value of Angio-IMR in Hypertrophic Cardiomyopathy Patients
NCT06434415
Second Affiliated Hospital, School of Medicine, Zhejiang University
Active Not RecruitingPRecIsion Medicine in CardiomyopathY
NCT04036799
The Hospital for Sick Children
UnknownExtended Ambulatory Monitoring Improves Risk Stratification in Hypertrophic Cardiomyopathy
NCT03182153
Atlantic Health System
UnknownStress Echo 2020 - The International Stress Echo Study
NCT03049995
Fatebenefratelli Hospital
UnknownMetabolomic Study of All-age Cardiomyopathy
NCT03061994
Beijing Institute of Heart, Lung and Blood Vessel Diseases
CompletedHypertrophic Cardiomyopathy Pilot Study
NCT02806479
Oregon Health and Science University
CompletedMitral Valve Management During Septal Myectomy
NCT03906734
Meshalkin Research Institute of Pathology of CirculationN/A
UnknownPerfusion Imaging With Myocardial Contrast Echocardiography in HCM
NCT02560467
Oregon Health and Science UniversityN/A
CompletedNon-Invasive Evaluation of Myocardial Stiffness by Elastography in Pediatric Cardiology (Elasto-Pédiatrie)
NCT02619825
French Cardiology SocietyN/A
CompletedHypertrophic Cardiomyopathy Symptom Release by BX1514M
NCT02590809
University Hospital, BordeauxPhase 2
UnknownAn Integrative-"Omics" Study of Cardiomyopathy Patients for Diagnosis and Prognosis in China
NCT03076580
Beijing Institute of Heart, Lung and Blood Vessel Diseases
UnknownNew Diagnostic Strategy in Hypertrophic Cardiomyopathy
NCT02520856
Assistance Publique Hopitaux De Marseille
CompletedHyper-synchronicity in Hypertrophic Cardiomyopathy (HCM) : Description, Mechanism and Origin With a Multi-imag
NCT02559726
University Hospital, BordeauxN/A
CompletedExercise in Genetic Cardiovascular Conditions
NCT02549664
Yale University
UnknownMorbidity and Mortality in Patients With Hypertrophic Cardiomyopathy: a CALIBER Study
NCT02424994
University College, London
CompletedStudy of Myocardial Deformation Parameters in Patients With Hypertrophic Cardiomyopathy
NCT04112511
AHEPA University Hospital
TerminatedEffect of Eleclazine (GS-6615) on Exercise Capacity in Subjects With Symptomatic Hypertrophic Cardiomyopathy
NCT02291237
Gilead SciencesPhase 2 / Phase 3
CompletedStudy Evaluating the Safety, Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-461
NCT02329184
MyoKardia, Inc.Phase 1
UnknownStudy of Hypertrophic Cardiomyopathy Under Stress Conditions. Concordance Between Two Complementary Tests: Str
NCT02500420
University Hospital, MontpellierN/A
CompletedAssessment of Wall Thickness in Hypertrophic Cardiomyopathy
NCT02234336
Mayo Clinic
CompletedEfficacy of Risk Assessment for Sudden Cardiac Death in Patients With Hypertrophic Cardiomyopathy
NCT04402268
Poznan University of Medical Sciences
UnknownPredictive Factors and Consequences of Myocardial Fibrosis in Hypertrophic Cardiomyopathy
NCT02922517
Nantes University Hospital
RecruitingPediatric Cardiomyopathy Mutation Analysis
NCT02432092
Indiana University
Active Not RecruitingHCMR - Novel Markers of Prognosis in Hypertrophic Cardiomyopathy
NCT01915615
University of Virginia
CompletedValsartan for Attenuating Disease Evolution In Early Sarcomeric HCM
NCT01912534
Carelon ResearchPhase 2
RecruitingEgyptian Hypertrophic Cardiomyopathy Program
NCT05884892
Magdi Yacoub Heart Foundation
RecruitingMolecular and Imaging Studies of Cardiovascular Health and Disease
NCT02804269
National Heart Centre Singapore
UnknownCardiac Biomarkers in Pediatric Cardiomyopathy (PCM Biomarkers)
NCT01873976
Wayne State University
CompletedGenotype-Phenotype Associations in Pediatric Cardiomyopathy (PCM GENES)
NCT01873963
Wayne State University
UnknownRisk Stratification in Children and Adolescents With Primary Cardiomyopathy
NCT03572569
German Heart Institute
CompletedRanolazine for the Treatment of Chest Pain in HCM Patients
NCT01721967
Duke UniversityPhase 4
UnknownTrimetazidine Therapy in Hypertrophic Cardiomyopathy
NCT01696370
University College, LondonPhase 2
CompletedA Biomarker and MRI Study on Troponin Release After Exercise in Hypertrophic Cardiomyopathy
NCT01559714
Heartcenter, University Medical Center St. Radboud
CompletedHypertrophic Regression With N-Acetylcysteine in HCM
NCT01537926
The University of Texas Health Science Center, HoustonPhase 1
UnknownExercise Training in Patients With Hypertrophic Cardiomyopathy
NCT01518114
Sheba Medical CenterN/A
CompletedInhibition of the Renin Angiotensin System With Losartan in Patients With Hypertrophic Cardiomyopathy
NCT01447654
Henning BundgaardPhase 2
TerminatedStudy to Develop a Non-invasive Marker for Monitoring Myocardial Fibrosis
NCT01230918
Ottawa Heart Institute Research CorporationPhase 2
UnknownOutcome of Different Pathogenic Mutations in Hypertrophic Cardiomyopathy
NCT03726424
Tongji Hospital
CompletedBiomarkers in Aortic Stenosis - B.A.S.S.
NCT01334801
Mayo Clinic
CompletedBiventricular Pacing in Hypertrophic Cardiomyopathy After Aortic Valve Replacement
NCT01081093
Johann Wolfgang Goethe University HospitalN/A
RecruitingFrench Hypertrophic Cardiomyopathy Observatory
NCT01091480
French Cardiology Society
UnknownRefining Information Technology Support for Genetics in Medicine
NCT01225978
Brigham and Women's Hospital
TerminatedGenetic Predictors of Outcome in HCM Patients
NCT00156429
University of Pittsburgh
CompletedOutcomes of Concomitant Bypass Surgery in Septal Myectomy
NCT06354413
Chinese Academy of Medical Sciences, Fuwai Hospital
CompletedAntiarrhythmic Therapy Versus Catheter Ablation for Atrial Fibrillation in Hypertrophic Cardiomyopathy
NCT00821353
National Institute of Cardiology, Warsaw, PolandPhase 3
CompletedClinical and Therapeutic Implications of Fibrosis in Hypertrophic Cardiomyopathy
NCT00879060
Tufts Medical CenterPhase 4
WithdrawnUse of Magnetic Field Mapping in the Evaluation of Patients With Hypertrophic Heart Disease (Thick Heart Muscl
NCT00574821
Cedars-Sinai Medical Center
WithdrawnThe Genetics of Cardiomyopathy and Heart Failure
NCT00703443
University of California, Irvine
CompletedStudy to Determine if Atorvastatin Reduces Size and Stiffness of Muscle in the Left Ventricle of the Heart
NCT00317967
University of CalgaryPhase 3
CompletedEffect of Losartan in Patients With Nonobstructive Hypertrophic Cardiomyopathy
NCT01150461
Massachusetts General HospitalPhase 2
CompletedPerhexiline Therapy in Patients With Hypertrophic Cardiomyopathy
NCT00500552
University Hospital BirminghamPhase 2
UnknownBiventricular Pacing in Hypertrophic Cardiomyopathy
NCT00504647
University Hospital BirminghamPhase 1
UnknownComparison of Data Obtained by Echocardiography and Magnetic Resonance Imaging in Hypertrophic Cardiomyopathy
NCT00315783
Assistance Publique - Hôpitaux de Paris
CompletedTreatment of Preclinical Hypertrophic Cardiomyopathy With Diltiazem
NCT00319982
Brigham and Women's HospitalPhase 2 / Phase 3
CompletedAssessment of Left Ventricular Torsion by Echocardiography Study
NCT00589836
The Cleveland Clinic
UnknownMolecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases
NCT00221832
Heidelberg University
CompletedAlcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: A Pilot Study
NCT00035386
National Heart, Lung, and Blood Institute (NHLBI)Phase 2
CompletedPirfenidone to Treat Hypertrophic Cardiomyopathy
NCT00011076
National Heart, Lung, and Blood Institute (NHLBI)Phase 2
RecruitingEvaluation of HEArt invoLvement in Patients With FABRY Disease
NCT03362164
Wuerzburg University Hospital
CompletedStudying the Effectiveness of Pacemaker Therapy in Children Who Have Thickened Heart Muscle
NCT00001960
National Heart, Lung, and Blood Institute (NHLBI)Phase 2
CompletedA Comparison of Two Treatments: Pacemaker and Percutaneous Transluminal Septal Ablation for Hypertrophic Cardi
NCT00001894
National Heart, Lung, and Blood Institute (NHLBI)Phase 2
CompletedFactors Contributing to Increased Left Ventricle Size in Patients With Abnormally Enlarged Hearts
NCT00001878
National Heart, Lung, and Blood Institute (NHLBI)
CompletedScreening for Inherited Heart Disease
NCT00001746
National Heart, Lung, and Blood Institute (NHLBI)
CompletedInvestigation Into the Use of Ultrasound Technique in the Evaluation of Heart Disease
NCT00001632
National Heart, Lung, and Blood Institute (NHLBI)
CompletedStudy of Blood Flow in Heart Muscle
NCT00001631
National Heart, Lung, and Blood Institute (NHLBI)Phase 2
CompletedLong Term Effects of Enalapril and Losartan on Genetic Heart Disease
NCT00001534
National Heart, Lung, and Blood Institute (NHLBI)
CompletedNatural History and Results of Dual Chamber (DDD) Pacemaker Therapy of Children With Obstructive Hypertrophic
NCT00001396
National Heart, Lung, and Blood Institute (NHLBI)Phase 1
CompletedFamily Studies of Inherited Heart Disease
NCT00001225
National Heart, Lung, and Blood Institute (NHLBI)
WithdrawnEfficacy, Safety, and Tolerability of Perhexiline in Subjects With Hypertrophic Cardiomyopathy and Heart Failu
NCT02431221
Heart Metabolics LimitedPhase 3
UnknownDiastolic Ventricular Interaction and the Effects of Biventricular Pacing in Hypertrophic Cardiomyopathy
NCT00698074
University Hospital BirminghamPhase 3
UnknownCHANCE - Candesartan in Hypertrophic Cardiomyopathy
NCT00430833
Charles University, Czech RepublicPhase 2