NCT03278457

Risk Stratification Using PET in HCM

Risk Stratification Using Positron Emission Tomography (PET) in Hypertrophic Cardiomyopathy (HCM)

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 25 (estimated)
• Sponsor: Region Gävleborg · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

The overall rationale is to reduce the risk of sudden cardiac death in individuals with hypertrophic cardiomyopathy (HCM). The novel approach of this study is to correlate Positron Emission Tomography (PET) findings to ventricular arrhythmias detected by the implantable cardioverter defibrillator (ICD). This could potentially lead to an improved risk stratification of HCM patients.

Detailed description

Positron Emission Tomography (PET) is a functional imaging technique that utilizes radioactive tracers to gain information on physiological or pathophysiological processes in vivo. Different tracers can provide information on different processes of interest. In cardiology, metabolic processes consuming oxygen (aerobic) can be studied with 11-Carbon-Acetate, sympathetic innervation can be studied with 11-Carbon-hydroxyephedrine and using 15-Oxygen-water the myocardial blood flow. Structural information of the heart such as left ventricular mass, left ventricular volumes and wall thickness can also be calculated with PET. The aim is to correlate PET parameters and burden of ventricular arrhythmias in order to improve risk stratification in HCM.

Conditions

• Hypertrophic Cardiomyopathy

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Positron Emission Tomography	Positron Emission Tomography

Timeline

• Start date: 2017-05-03
• Primary completion: 2018-01-03
• Completion: 2018-06-03
• First posted: 2017-09-11
• Last updated: 2017-09-11

Locations

1 site across 1 country: Sweden