NCT00001631

Study of Blood Flow in Heart Muscle

Study of Myocardial Perfusion by MRI

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 249 (planned)
• Sponsor: National Heart, Lung, and Blood Institute (NHLBI) · NIH
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Blood flows to areas of the heart providing oxygen and fuel to the pumping muscle. Occasionally the arteries providing the fuel can become blocked. This occurs in coronary artery disease. Magnetic resonance imaging (MRI) can be used to evaluate the blood flow to different areas of the heart muscle. In this study magnetic resonance imaging will be compared to other diagnostic tests (radionucleotide perfusion studies) capable of measuring blood flow to heart muscle.

Detailed description

In this pilot study, magnetic resonance imaging (MRI) of myocardial enhancement during first passage of intravenously injected gadolinium contrast will be used to evaluate regional myocardial perfusion in patients with known or suspected coronary artery disease and hypertrophic cardiomyopathy. The MRI results will be compared with conventional radionuclide perfusion studies (ex. dipyridamole thallium). A clinically defined normal group will also be studied without radionuclide correlation.

Conditions

• Coronary Disease
• Healthy
• Hypertrophic Cardiomyopathy
• Myocardial Ischemia

Interventions

Type	Name	Description
PROCEDURE	Magnetic resonance imaging

Timeline

• Start date: 1997-08-01
• Completion: 2003-01-01
• First posted: 1999-11-04
• Last updated: 2008-03-04

Locations

1 site across 1 country: United States