NCT05818605

Exercise Intolerance in Non-obstructive Hypertrophic Cardiomyopathy

The EXerCise traIning To rEcovery in HCM Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The EXCITE-HCM study is a randomized, controlled, blinded clinical trial designed to evaluate the effect of moderate intensity exercise training versus usual physicial activity on the improvement of HCM-related symptoms and cardiac function. About 70 participants will be recruited and randomized on a 1:1 ratio to either moderate intensity training or usual physicial activity interventions. Patients will be followed during a period of 24 weeks and assesesments as physical examination, questionnaires, 12 lead ecg's, biomarker levels, echocardiogram, Cardiac Magnetic resonance, PET and CPET will be performed to evaluate their response to the intervention.

Conditions

• Hypertrophic Cardiomyopathy

Interventions

Type	Name	Description
BEHAVIORAL	Moderate Intensity Exercise Program	Subjects randomized to the EXER arm will undergo 24 weeks of Moderate Intensity Exercise Training (MIET). Patients will be signed up for 60-minute exercise sessions, 3 times a week

Timeline

• Start date: 2023-02-17
• Primary completion: 2027-03-01
• Completion: 2027-03-01
• First posted: 2023-04-19
• Last updated: 2025-11-20

Locations

1 site across 1 country: United States