| Not Yet Recruiting | Phase 4, Double-blind Study Evaluating the Response on Computed Tomography (CT) Lung Density Decline Rates of NCT07326592 | CSL Behring | Phase 4 |
| Not Yet Recruiting | Ventilation-Perfusion Discrepancy Index Versus Conventional Anatomic-Physiologic Assessment for Target Lung Lo NCT07403617 | China-Japan Friendship Hospital | N/A |
| Not Yet Recruiting | A Multi Center Study Testing a New Implant for Adults With Severe Emphysema NCT07119229 | Pulmair Medical, Inc. | N/A |
| Recruiting | A Trial of the Implantable Artificial Bronchus 50 Flex in Patients With Severe Emphysema NCT07086339 | Pulmair Medical, Inc. | N/A |
| Recruiting | Implementation of a Sarcopenia Clinic to Diagnose and Treat Skeletal Muscle Loss Due to COPD NCT07059637 | The Cleveland Clinic | N/A |
| Not Yet Recruiting | Utilising Hull Lung Health Study Data to Investigate the Performance of TidalSense Diagnostic Algorithms to Id NCT06788613 | Chiesi UK | — |
| Recruiting | Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3 NCT06891755 | Apreo Health, Inc. | N/A |
| Not Yet Recruiting | Endobronchial Silicone Valve for Patients With Emphysema NCT07097896 | China-Japan Friendship Hospital | N/A |
| Recruiting | The REDUCE EU Study - Endobronchial Thermal Liquid Ablation (ETLA) for the Treatment of Emphysema NCT06655428 | Morair Medtech, LLC | N/A |
| Recruiting | Analysing Peripheral Skeletal Muscle Function Before and After Endobronchial Valve Treatment NCT06025500 | University Medical Center Groningen | — |
| Recruiting | Clinical-ultrasonographic Assessment of Pulmonary Emphysema NCT06533371 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Recruiting | Identification of Multiple Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled Bre NCT06528418 | ChromX Health | — |
| Active Not Recruiting | Long-term, Open-label Study of SAR447537 (INBRX-101) in Adults With Alpha-1 Antitrypsin Deficiency Emphysema NCT05897424 | Sanofi | Phase 2 |
| Recruiting | Safety and Efficacy of Endobronchial Valve for Bronchoscopic Lung Volume Reduction Surgery: a Prospective Pilo NCT06349174 | China-Japan Friendship Hospital | N/A |
| Completed | Anti-Platelets in Chronic Obstructive Pulmonary Disease NCT05567562 | Brigham and Women's Hospital | Phase 2 |
| Recruiting | Zephyr Valve Japan Post-Marketing Surveillance NCT06332885 | Pulmonx Corporation | — |
| Recruiting | Biological Effects of Quercetin in COPD Phase II NCT06003270 | Temple University | Phase 2 |
| Enrolling By Invitation | Using Artificial Intelligence for the Detection of Respiratory Diseases Associated With Pollution NCT06512142 | University of Medicine and Pharmacy "Victor Babes" Timisoara | — |
| Completed | Study of SAR447537 (INBRX-101) Compared to Plasma-derived A1PI Therapy in Adults With AATD Emphysema NCT05856331 | Sanofi | Phase 2 |
| Recruiting | Exploring Novel Biomarkers for Emphysema Detection NCT05825261 | Maastricht University | — |
| Terminated | A Randomized Controlled Trial of InterVapor® in France - The TARGET Trial NCT05118269 | Uptake Medical Technology, Inc. | N/A |
| Completed | Emphysema and FLNA Mutation (E-FLNA) NCT05550844 | University Hospital, Lille | — |
| Completed | Assessing the DIAphragM Before ANd After Endobronchial Valve Treatment NCT04735731 | University Medical Center Groningen | — |
| Recruiting | Characterizing Matrix Metalloproteinase-12 (MMP12) in Sputum NCT04761393 | McMaster University | — |
| Active Not Recruiting | Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial) NCT05382208 | Weill Medical College of Cornell University | Phase 2 |
| Unknown | Functional Lung Imaging in Patients With Respiratory Compromise Undergoing Endobronchial Valve Placement NCT05204875 | Temple University | — |
| Active Not Recruiting | A Multicenter, Prospective Trial of the IAB in Adults Suffering From COPD/Emphysema NCT05087641 | Pulmair Medical, Inc. | N/A |
| Completed | Pulmonary and Cardiac Effects of E-Cigarette Use in Pulmonary Patients Who Smoke Cigarettes NCT05610514 | University of Vermont | Phase 2 |
| Unknown | Study on the Influence of Climatic and Environmental Factors on Respiratory Diseases in Sanya, Hainan Province NCT05330637 | Shanghai Jiao Tong University School of Medicine | — |
| Completed | Evaluation of Immunological, Microbiological and Metabolomic Profiles in COPD NCT06826560 | Medical University of Warsaw | — |
| Enrolling By Invitation | Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs NCT04930289 | Paragonix Technologies | — |
| Recruiting | STRIVE Post-Market Registry Study NCT04302272 | Olympus Corporation of the Americas | — |
| Unknown | Effect of EPAP Device on Emphysema and Lung Bullae NCT04742114 | Qilu Hospital of Shandong University | N/A |
| Unknown | The Lung Microbiome and Endobronchial Valve Treatment NCT04932811 | Aarhus University Hospital | — |
| Completed | Mind The Gap - Crossing Borders Study NCT04256408 | University Medical Center Groningen | N/A |
| Completed | 4D Medical X-ray Velocimetry for Bronchoscopic Lung Volume Reduction Targeting NCT04786171 | Vanderbilt University Medical Center | — |
| Completed | Fissure Closure With the AeriSeal System for CONVERTing Collateral Ventilation Status (CONVERT) NCT04559464 | Pulmonx Corporation | N/A |
| Terminated | Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders NCT02748798 | Thunder Bay Regional Health Research Institute | EARLY_Phase 1 |
| Completed | Lung Damage Caused by SARS-CoV-2 Pneumonia (COVID-19) NCT04435327 | University of Milano Bicocca | — |
| Recruiting | Surgical Compared to Bronchoscopic Lung Volume Reduction in Patients With Severe Emphysema NCT04537182 | Isabelle Opitz, Professor, MD | N/A |
| Unknown | Right Ventricular Diastolic Dysfunction NCT04467242 | University Hospital, Montpellier | — |
| Recruiting | Kingston Chronic Obstructive Pulmonary Disease (COPD) Multidimensional Long Term Follow up Cohort NCT04200079 | Dr. Juan Pablo de Torres Tajes | — |
| Completed | Feasibility of a Multi Component Intervention in Patients With Severe Dyspnea and Obesity NCT03836547 | Mayo Clinic | N/A |
| Active Not Recruiting | Zephyr Valve Registry (ZEVR) NCT04186546 | Pulmonx Corporation | — |
| Unknown | Cinenses Lung Volume Reduction Reverser System First-in-man Study Treating Patients With Severe Emphysema NCT03685526 | Lifetech Scientific (Shenzhen) Co., Ltd. | N/A |
| Completed | Mortality and Symptom Burden Post Hospitalisation With COPD NCT03657121 | Northumbria Healthcare NHS Foundation Trust | — |
| Terminated | Hyperinflation Assessment After Treatment by Lung Volume Reduction Coil NCT02835001 | University Hospital, Toulouse | N/A |
| Completed | Home Pulmonary Rehabilitation for COPD NCT03480386 | Mayo Clinic | N/A |
| Completed | A Home-based Intervention to Promote Mindful Breathing Awareness Through Pursed-lip Breathing Training for COP NCT03814980 | Mayo Clinic | N/A |
| Completed | A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Pla NCT03636347 | Mereo BioPharma | Phase 2 |
| Completed | Belimumab Treatment of Emphysema Patients With Anti-GRP78 Autoantibodies NCT03244059 | University of Alabama at Birmingham | Phase 2 |
| Completed | A Trial on the Effects of Bronchoscopic Lung Volume Reduction in Severe Emphysema. NCT03474471 | University Medical Center Groningen | N/A |
| Completed | Mechanistic Effects of Health Coaching to Reduce Chronic Obstructive Pulmonary Disease (COPD) Hospitalizations NCT03837847 | Mayo Clinic | N/A |
| Withdrawn | Melodica Orchestra for Dyspnea: Safety and Feasibility Pilot NCT03653104 | VA Quality Enhancement Research Intiative | N/A |
| Completed | Comparison of the Effectiveness of Home and Hospital-based PR in Candidate Patients With BLVR NCT03518177 | Istanbul Medipol University Hospital | N/A |
| Completed | Study of PneumRx Endobronchial Coil System in Treatment of Subjects With Severe Emphysema NCT03360396 | Boston Scientific Corporation | N/A |
| Recruiting | Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease NCT03455686 | McMaster University | N/A |
| Completed | Smoking Cessation and Functional CT Assessment NCT03382106 | Eric A. Hoffman | Phase 4 |
| Withdrawn | Evaluating the Clinical Effectiveness of 3D Printing for a Patient-specific Silicone Stent Airway Implant NCT03111888 | The Cleveland Clinic | N/A |
| Unknown | LVR in Severe Emphysema Using Bronchoscopic Autologous Blood Instillation in Combination With Intra-bronchial NCT03010449 | Royal Brompton & Harefield NHS Foundation Trust | N/A |
| Active Not Recruiting | Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema NCT02682147 | Eric A. Hoffman | Phase 4 |
| Completed | Implementing and Evaluating the Genie Tool in COPD NCT02935452 | University of Southampton | N/A |
| Completed | Losartan Effects on Emphysema Progression NCT02696564 | JHSPH Center for Clinical Trials | Phase 4 |
| Completed | Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Defici NCT03114020 | Gerard Turino | Phase 2 |
| Unknown | Studying the Airway Microenvironment in Patients Undergoing Surgical and Bronchoscopic Interventions for COPD NCT03010592 | Royal Brompton & Harefield NHS Foundation Trust | — |
| Active Not Recruiting | BROnchoalveolar Investigations of Never-smokers With Chronic Obstruction From the Swedish CardioPulmonary bioI NCT03049202 | Karolinska Institutet | — |
| Unknown | Lung Volume Reduction Coil Microbiome Study NCT03010566 | Royal Brompton & Harefield NHS Foundation Trust | — |
| Recruiting | Site and Mechanism(s) of Expiratory Airflow Limitation in COPD, Emphysema and Asthma-COPD Overlap NCT03263130 | Gelb, Arthur F., M.D. | — |
| Completed | Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency NCT03008915 | Columbia University | Phase 2 |
| Terminated | Endoscopic Lung Volume Reduction Coil Treatment in Patients With Chronic Hypercapnic Respiratory Failure NCT02996149 | Universitätsklinikum Hamburg-Eppendorf | — |
| Completed | Clinical Investigation of a Modified Staged Treatment Algorithm Using the AeriSeal System NCT02877459 | Pulmonx Corporation | N/A |
| Terminated | The Relationship Between GOLD Risk Group and Clinical Outcomes in a Community-based COPD Cohort NCT02838108 | Duke University | — |
| Completed | REACH SVS Control Patient Cross-Over Study NCT02914340 | Olympus Corporation of the Americas | N/A |
| Completed | Home-based Health Management of Chronic Obstructive Lung Disease (COPD) Patients NCT02999685 | Mayo Clinic | N/A |
| Completed | Advancing Symptom Alleviation With Palliative Treatment NCT02713347 | VA Office of Research and Development | N/A |
| Completed | Activity Monitor Use in COPD Patients Undergoing Rehabilitation NCT02895152 | Northern Care Alliance NHS Foundation Trust | N/A |
| Completed | SCCOR Minorities Observational Study NCT02898272 | University of Pittsburgh | — |
| Unknown | Endobronchial Valve in Patients With Heterogeneous Emphysema NCT02823223 | Chinese PLA General Hospital | N/A |
| Completed | Prevalence of Sleep Disordered Breathing in a Lung Cancer Screening Cohort NCT02687997 | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | N/A |
| Completed | Computed Tomography Assessment of Regional Ventilation (CURVE) NCT02879773 | Heart of England NHS Trust | — |
| Completed | The Effect of Physical Activity Promotion on Short and Long-term Outcomes in COPD NCT02099799 | VA Office of Research and Development | N/A |
| Terminated | A Prospective Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the OL-BF-001 for Severe NCT02470052 | Olympus Corporation | N/A |
| Terminated | Changes in Lung Physiology and Cardiac Performance in Patients With Emphysema Post Bilateral RePneu Coil Treat NCT02499380 | Boston Scientific Corporation | — |
| Unknown | Spiration Valve System 9 mm European Post Market Evaluation Study NCT03008226 | Heidelberg University | — |
| Completed | Genetics of the Combined Pulmonary Fibrosis and Emphysema Syndrome NCT02439528 | Hospices Civils de Lyon | N/A |
| Completed | Alpha-1 Carrier Genomics Study NCT02810327 | Medical University of South Carolina | — |
| Completed | Doxycycline for COPD in HIV-Infected Patients NCT01744093 | Weill Medical College of Cornell University | N/A |
| Completed | Improvement of Sleep Quality by RePneu® Coils in Advanced Pulmonary Emphysema NCT02399514 | Institut für Pneumologie Hagen Ambrock eV | N/A |
| Withdrawn | Lung Volume Reduction Coils for Emphysema in Alpha-1 Antitrypsin Deficiency NCT02273349 | University Hospital, Saarland | N/A |
| Completed | Electrical Impedance Imaging of Patients on Mechanical Ventilation NCT02232841 | Colorado State University | — |
| Completed | Longitudinal Evaluation of HIV-associated Lung Disease Phenotypes NCT02238327 | University of Pittsburgh | — |
| Recruiting | COPD Patient-Powered Research Network NCT02803242 | COPD Foundation | — |
| Completed | Assessment of Emphysema Using 1.5T MRI With UTE Pulse Sequences NCT02100800 | University Hospital, Bordeaux | N/A |
| Completed | Mindfulness-based Cognitive Therapy for Chronic Obstructive Pulmonary Disease NCT02042976 | University of Aarhus | N/A |
| Recruiting | DEPRECAP: Lung Cancer Screening Programme by LDCT for Patients With COPD or Emphysema. NCT06690385 | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | — |
| Completed | HIV+ Alveolar Macrophage Oxidant-mediated Apoptosis of Pulmonary Endothelium NCT02056158 | Weill Medical College of Cornell University | — |
| Completed | A Safety and Feasibility Study of Re-treating Patients With Severe Emphysema With the RePneu LVRC System. NCT02012673 | University Medical Center Groningen | N/A |
| Completed | Prostaglandin Inhibition for Emphysema NCT02006576 | University of Nebraska | Phase 2 |
| Terminated | LVRC IDE Crossover Study (Crossover From IDE Trial CLN0009) NCT02059057 | Boston Scientific Corporation | N/A |
| Completed | Safety and Clinical Outcomes Study: SVF Deployment for Orthopedic, Neurologic, Urologic, and Cardio-pulmonary NCT01953523 | Elliot Lander | N/A |
| Withdrawn | Study of the AeriSeal System Treatment in Patients With Advanced Non-Upper Lobe Predominant Heterogeneous Emph NCT01908933 | Aeris Therapeutics | Phase 3 |
| Completed | Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitab NCT01615484 | University of North Carolina, Chapel Hill | N/A |
| Completed | Pulmonx Endobronchial Valves Used in Treatment of Emphysema (LIBERATE Study) NCT01796392 | Pulmonx Corporation | N/A |
| Completed | Sequential Segmental Treatment of Emphysema With Upper Lobe Predominance (STEP-UP) Study NCT01719263 | Uptake Medical Corp | N/A |
| Completed | Evaluation of the Spiration® Valve System for Emphysema to Improve Lung Function NCT01812447 | Olympus Corporation of the Americas | N/A |
| Terminated | Post Market Observational, Prospective, Multi-center Study NCT01806636 | Boston Scientific Corporation | — |
| Completed | The Effectiveness of Roflumilast in Improving Mucociliary Clearance in Patients With COPD and Chronic Bronchit NCT03073798 | Johns Hopkins University | Phase 4 |
| Unknown | Lung Volume Reduction Coil Treatment in Emphysema. NCT01822795 | CHU de Reims | Phase 3 |
| Completed | Lung Volume Reduction for Severe Emphysema by Stereotactic Ablative Radiation Therapy NCT03673176 | Stanford University | N/A |
| Unknown | Bronchoscopic Thermal Saline Ablation (BTSA) of Emphysematous Lung. A New Emphysema Therapy NCT01920321 | Assaf-Harofeh Medical Center | Phase 1 / Phase 2 |
| Completed | The Effect of Pulmonary Rehabilitation on Bronchoscopic Volume Reduction Process Success NCT04347044 | Istanbul Medipol University Hospital | N/A |
| Unknown | Safety Study of Endobronchial Transplantation of Autologous Mesenchymal Stem Cells (MSCs) in Emphysema Patient NCT01758055 | Arda Kiani | Phase 1 |
| Terminated | Lung Volume Reduction Coil Treatment in Patients With Emphysema (RENEW) Study NCT01608490 | Boston Scientific Corporation | N/A |
| Completed | Evaluation of Physiologic Parameters to Study the Mechanism of Action of the Lung Volume Reduction Coil in Sub NCT01421082 | Boston Scientific Corporation | Phase 2 / Phase 3 |
| Completed | Imaging Lung Function Using Oxygen Enhanced MRI NCT01731015 | Hal C Charles | Phase 1 |
| Completed | A Study of the Use of Chartis System to Optimize Subject Selection for Endobronchial Lung Volume Reduction (EL NCT01101958 | Pulmonx Corporation | N/A |
| Unknown | Evaluate the Effects of Formoterol and Beclomethasone Dipropionate Combination Therapy on Small Airways Functi NCT01466712 | KU Leuven | Phase 4 |
| Completed | Blood, Hair and Lung Concentrations of Metals and Metalloids in Patients With Lung Cancer or Chronic Obstructi NCT01949181 | Hopital Foch | N/A |
| Completed | Rehabilitation in Chronic Obstructive Pulmonary Disease (COPD) Patients With Emphysema NCT01305668 | Villa Pineta Hospital | — |
| Completed | Hypoxic Pulmonary Vasoconstriction Pilot Study NCT03733470 | Eric A. Hoffman | Phase 4 |
| Unknown | Sunovion Brovana Versus Serevent Inspiratory Capacity High Resolution Computed Tomography NCT01361984 | University of California, Los Angeles | Phase 4 |
| Completed | A Study to Evaluate the Integrated Dose Counter on an Albuterol Hydrofluoroalkane (HFA) Metered Dose Inhaler ( NCT01302587 | Teva Branded Pharmaceutical Products R&D, Inc. | — |
| Unknown | Effect of Symbicort on Sleep Quality in Patients With Emphysema NCT01602523 | Temple University | Phase 3 |
| Completed | Eccentric Exercise Training as Novel Rehabilitation for Chronic Obstructive Pulmonary Disease (COPD) NCT01077102 | McGill University Health Centre/Research Institute of the McGill University Health Centre | N/A |
| Terminated | A Registry Study of the AeriSeal® System or Lung Volume Reduction in Patients With Advanced Emphysema NCT01449175 | Aeris Therapeutics | — |
| Unknown | Effects of Exercise Training on Systemic Inflammation an Muscle Repair According to the Obstructive Chronic Pu NCT01431625 | Hospitales Universitarios Virgen del Rocío | Phase 4 |
| Terminated | Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability NCT01241942 | University of North Carolina, Chapel Hill | N/A |
| Active Not Recruiting | Study of COPD Subgroups and Biomarkers NCT01969344 | University of North Carolina, Chapel Hill | — |
| Completed | Safety and Pharmacokinetics of Alpha-1 Proteinase Inhibitor in Subjects With Alpha1-Antitrypsin Deficiency NCT01213043 | Grifols Therapeutics LLC | Phase 2 |
| Completed | Safety and Feasibility Study of Administration of Mesenchymal Stemcells for Treatment of Emphysema NCT01306513 | Leiden University Medical Center | Phase 1 |
| Completed | Prognostic Indicators as Provided by the EPIC ClearView NCT01476995 | Epic Research & Diagnostics, Inc. | — |
| Completed | Study on Phenotypic Characterization of Combined Pulmonary Fibrosis and Emphysema NCT01121367 | Beijing Chao Yang Hospital | — |
| Completed | Randomized Comparison of the RePneu Lung Volume Reduction Coil (LVRC) to Standard of Care for the Treatment of NCT01334307 | Boston Scientific Corporation | Phase 1 |
| Completed | Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction NCT01041586 | Uptake Medical Corp | Phase 1 |
| Completed | International Study Evaluating the Safety and Efficacy of Inhaled, Human, Alpha-1 Antitrypsin (AAT) in Alpha-1 NCT01217671 | Kamada, Ltd. | Phase 2 / Phase 3 |
| Completed | Feasibility Study of PneumRx's Lung Volume Reduction Coil (LVRC) NCT01328899 | Boston Scientific Corporation | Phase 1 / Phase 2 |
| Completed | Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction NCT01102712 | Uptake Medical Corp | N/A |
| Completed | Bronchoscopic Lung Volume Reduction Using Blood NCT01528267 | Chelsea and Westminster NHS Foundation Trust | Phase 2 |
| Unknown | Bronchoreversibility and Radiologic Morphology of Emphysema NCT02008162 | University of Rome Tor Vergata | — |
| Completed | AeriSeal System for Lung Volume Reduction NCT01051258 | Aeris Therapeutics | Phase 1 / Phase 2 |
| Completed | Evaluation of Regional Ventilation Using 19F MRI of Inert Perfluorinated Gases Mixed With Oxygen NCT01710449 | Hal C Charles | Phase 1 |
| Completed | The Natural History of Gene Expression in the Lung Cells of Non-Smokers, Smokers and Ex-Smokers in Health and NCT00974064 | Weill Medical College of Cornell University | — |
| Withdrawn | CryoSpray Ablation(tm)Thoracic Patient Registry NCT00785239 | CSA Medical, Inc. | — |
| Completed | Lung HIV Disease in a Large Cohort-Pitt NCT01326572 | University of Pittsburgh | — |
| Completed | Prevalence and Pathogenesis of Lung Disease in a Large HIV Cohort-coordinating Center NCT00870857 | University of Pittsburgh | — |
| Completed | Efficacy of Losartan in Preventing Progression of COPD NCT00720226 | Johns Hopkins University | Phase 4 |
| Completed | Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor NCT00670007 | CSL Behring | Phase 4 |
| Unknown | Simvastatin in Chronic Obstructive Pulmonary Disease (COPD) NCT00680641 | University of East Anglia | Phase 4 |
| Withdrawn | Perforomist Versus Foradil Evaluated by Inspiratory Capacity and High Resolution Computed Tomography (HRCT) NCT00633776 | University of California, Los Angeles | Phase 4 |
| Withdrawn | Sequential Endoscopic Lung Volume Reduction NCT00613860 | Heidelberg University | Phase 3 |
| Completed | Evaluation of the PneumRx Lung Volume Reduction Coil to Treat Emphysema NCT01220908 | Boston Scientific Corporation | N/A |
| Active Not Recruiting | Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD) NCT00608764 | Brigham and Women's Hospital | — |
| Completed | Evaluating Genetic Factors That May Contribute to Elastin Function and the Development of Chronic Obstructive NCT00725309 | Washington University School of Medicine | — |
| Completed | Biomarkers and Genetic Factors Related to Emphysema NCT00757120 | Washington University School of Medicine | — |
| Completed | Clinical Trial to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Treatment of Severe E NCT00475007 | Olympus Corporation of the Americas | N/A |
| Suspended | Vibration Response Imaging (VRI) in Patients That Are Candidates for Undergoing Pulmonary Operation Procedure NCT00523094 | Deep Breeze | — |
| Completed | Pneumocystis in Pathogenesis of HIV-associated Emphysema NCT00869544 | University of Pittsburgh | — |
| Unknown | EUROPT Clinical Trial to Study the Efficacy of One-Way Valve Implantation (New Treatment Algorithm) in Patient NCT00730301 | LudwLudwig Boltzmann Institute for COPD and Respiratory Epidemiology | Phase 4 |
| Active Not Recruiting | Clinical & Systems Medicine Investigations of Smoking-related Chronic Obstructive Pulmonary Disease NCT02627872 | Karolinska Institutet | — |
| Completed | TESRA: (Treatment of Emphysema With a Gamma-Selective Retinoid Agonist) NCT00413205 | Hoffmann-La Roche | Phase 2 |
| Completed | Efficacy Safety Study of Arformoterol/Tiotropium Combination Versus Either Therapy Alone in Chronic Obstructiv NCT00424528 | Sumitomo Pharma America, Inc. | Phase 4 |
| Terminated | Bronchitis and Emphysema Advice and Training to Reduce Hospitalization NCT00395083 | US Department of Veterans Affairs | Phase 2 |
| Unknown | EASE Trial: Exhale Airway Stents for Emphysema NCT00391612 | Broncus Technologies | Phase 3 |
| Completed | Real-Time Support for Exercise Persistence in COPD NCT00373932 | University of Washington | Phase 1 / Phase 2 |
| Completed | Alveolar Macrophage Proteomics in HIV-associated Emphysema NCT00823927 | Philip Diaz | — |
| Completed | Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency NCT00261833 | CSL Behring | Phase 4 |
| Completed | Single-Breath Measurement Underestimates Ventilatory Volume According to Emphysema Severity NCT00528944 | Columbia University | — |
| Withdrawn | Use of the Hattler Respiratory Assist Catheter in Severe Respiratory Failure NCT00288964 | Alung Technologies | Phase 3 |
| Completed | Safety and Efficacy of Arformoterol Tartrate Inhalation Solution in Subjects With Chronic Obstructive Pulmonar NCT00250679 | Sumitomo Pharma America, Inc. | Phase 3 |
| Completed | Macrophage Phagocytosis in COPD NCT00298389 | Imperial College London | — |
| Withdrawn | Macrophages in Smokers' Lung NCT00298402 | Imperial College London | — |
| Completed | The Effect of Breathing Helium-Hyperoxia During Pulmonary Rehabilitation in Patients With COPD NCT00406705 | University of Alberta | Phase 2 |
| Completed | Sildenafil for Chronic Obstructive Pulmonary Disease NCT00104637 | Kawut, Steven, MD | Phase 2 |
| Unknown | Management of Patients With Alpha-1 Antitrypsin Deficiency Associated Emphysema NCT00700934 | Assistance Publique - Hôpitaux de Paris | — |
| Terminated | Endobronchial Valve for Emphysema PalliatioN Trial (VENT) Cost-effectiveness Sub-Study NCT00137956 | Emphasys Medical | Phase 3 |
| Completed | Improving the Quality of End-of-Life Communication for Patients With Chronic Obstructive Pulmonary Disease (CO NCT00106080 | VA Office of Research and Development | N/A |
| Unknown | Endothelial Dysfunction, Biomarkers, and Lung Function -Ancillary to MESA NCT00843271 | Columbia University | — |
| Unknown | Assessment of Heart and Heart-Lung Transplant Patient Outcomes Following Pulmonary Rehabilitation NCT00129350 | Royal Brompton & Harefield NHS Foundation Trust | Phase 1 |
| Completed | Tiotropium Induced Bronchodilation in Lung CT Scored Emphysema NCT00570544 | Gelb, Arthur F., M.D. | — |
| Completed | Exhale (R) Stent for Emphysema NCT00207337 | Broncus Technologies | Phase 2 / Phase 3 |
| Terminated | Thorax Enlarging Surgery: a Novel Surgical Approach to Emphysema NCT00650559 | KU Leuven | N/A |
| Completed | Study Comparing Simulect Plus Standard Immunosuppression to Standard Immunosuppression Alone for the Preventio NCT00188825 | University Health Network, Toronto | Phase 3 |
| Completed | Airway Clearance for Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation NCT00181207 | Johns Hopkins University | Phase 4 |
| Completed | Leukocyte Function in Asthma and COPD NCT00147069 | Imperial College London | — |
| Completed | Distribution of Regional Lung Function by Vibration Response Imaging NCT01229020 | Deep Breeze | — |
| Completed | Evaluation of the Lungs of Individuals With Lung Disease NCT00224198 | Weill Medical College of Cornell University | — |
| Completed | Endobronchial Valve for Emphysema Palliation Trial (VENT) NCT00129584 | Emphasys Medical | Phase 3 |
| Completed | Pilot Study of the Spiration IBV™ System NCT00145548 | Olympus Corporation of the Americas | Phase 2 |
| Terminated | Evaluating Genes in Sputum to Measure Drug Response in COPD NCT00233051 | National Jewish Health | N/A |
| Completed | Effectiveness of Different Exercise Training Programs to the Profile of COPD Patients NCT01336283 | Hospitales Universitarios Virgen del Rocío | Phase 4 |
| Completed | Regulation of Inflammatory Mediators in Chronic Obstructive Pulmonary Disease NCT00147095 | Imperial College London | — |
| Completed | To Evaluate the Long-term Safety of (R,R)-Formoterol in Subjects With COPD NCT00064415 | Sumitomo Pharma America, Inc. | Phase 3 |
| Completed | Determine the Safety and Efficacy of (R,R)-Formoterol in the Treatment of Subjects With COPD NCT00064402 | Sumitomo Pharma America, Inc. | Phase 3 |
| Completed | Inhaled Steroid Reduces Systemic Inflammation in COPD NCT00175565 | University of British Columbia | Phase 4 |
| Completed | Regulation of the Release of Inflammatory Mediators From Lung Macrophages. NCT00147017 | Imperial College London | — |
| Completed | Efficacy of Osteopathic Manipulation in Chronic Obstructive Pulmonary Disease NCT00034112 | National Center for Complementary and Integrative Health (NCCIH) | Phase 2 |
| Completed | Leukocyte Function in Chronic Obstructive Pulmonary Disease (COPD) NCT00147082 | Imperial College London | — |
| Completed | Lung Volume Reductions Surgery (LVRS) Study NCT00018525 | US Department of Veterans Affairs | N/A |
| Recruiting | Emphysema Research Registry and Biosample Repository NCT00307281 | University of Pittsburgh | — |
| Terminated | Evaluating the Effects of Surgical and Non-Surgical Treatment Options in People With Emphysema NCT00675454 | Washington University School of Medicine | — |
| Completed | Feasibility of Retinoic Acid Treatment in Emphysema (FORTE) NCT00000621 | National Heart, Lung, and Blood Institute (NHLBI) | Phase 2 |
| Completed | National Emphysema Treatment Trial (NETT) NCT00000606 | National Heart, Lung, and Blood Institute (NHLBI) | Phase 3 |
| Completed | Characterization of the Pathobiology of Early Lung Destruction in Alpha 1-Antitrypsin Deficient Individuals NCT00001462 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | Medication Adherence in COPD--A Self-Regulation Study NCT00005717 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | Emphysema: Physiologic Effects of Nutritional Support NCT00000573 | National Heart, Lung, and Blood Institute (NHLBI) | Phase 2 |
| Completed | Alpha1-antitrypsin Deficiency Registry NCT00005292 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | Tucson Epidemiology Study of Chronic Obstructive Lung Diseases NCT00005279 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | Honolulu Heart Program NCT00005123 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | Cost-Effectiveness of Lung Volume Reduction Surgery NCT00013156 | US Department of Veterans Affairs | Phase 2 |