NCT03733470

Hypoxic Pulmonary Vasoconstriction Pilot Study

Pilot Study for Perfusion Heterogeneity: a Mechanistic Image-Based Emphysema Phenotype

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: Eric A. Hoffman · Academic / Other
• Sex: All
• Age: 30 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine if the events leading to smoking-associated centrilobular and paraseptal emphysema are caused by a failure of the lungs' inherent mechanisms to block hypoxic pulmonary vasoconstriction (HPV) in areas of smoking-induced inflammation.

Detailed description

Overall goals of this study are to 1) determine the effects on sildenafil on the heterogeneity perfused blood volume in smokers susceptible to emphysema using dual energy CT 2) utilize pulmonary blood volume heterogeneity as an image-based biomarker to differentiate normal and susceptible smokers.

Conditions

• Emphysema

Interventions

Type	Name	Description
DRUG	Sildenafil study group	One dose of 20 mg Sildenafil will be given one hour before CT imaging.

Timeline

• Start date: 2011-06-29
• Primary completion: 2014-01-13
• Completion: 2014-01-13
• First posted: 2018-11-07
• Last updated: 2019-10-01
• Results posted: 2019-10-01

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study