NCT00570544

Tiotropium Induced Bronchodilation in Lung CT Scored Emphysema

Effectiveness of Tiotropium to Maintain Inspiratory Capacity Against Metronome Paced Hyperventilation Induced Dynamic Hyperinflation in COPD Patients With Lung CT Scored Emphysema

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 29 (actual)
• Sponsor: Gelb, Arthur F., M.D. · Individual
• Sex: All
• Age: 40 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

To evaluate if tiotropium (Spiriva)induced bronchodilation of inspiratory capacity in patients with moderate to severe copd subjected to metronome paced hyperventilation induced dynamic hyperinflation is dependent upon the extent of underlying emphysema as determined by high resolution-thin section CT lung.

Detailed description

We will analyze post hoc, data that was previously published: Gelb AF et al.Chest 2006;131:690-695. We have shown that tiotropium increases resting inspiratory capacity thereby providing lung volume protection against metronome paced hyperventilation induced dynamic hyperinflation. End point will be to correlate increase in tiotropium induced FEV 1(L) and inspiratory capacity with extent of underlying emphysema as scored by lung CT ( Gelb AF et al:Chest 1996; 109: 353-359)in 29 patients with COPD. We will also correlate the decrease in inspiratory capacity following metronome paced hyperventilation induced dynamic hyperinflation with extent of lung CT scored emphysema.

Conditions

• COPD
• Emphysema

Interventions

Type	Name	Description
DRUG	tiotropium	18ug capsule daily for 30 days

Timeline

• Start date: 2004-08-01
• Completion: 2005-08-01
• First posted: 2007-12-11
• Last updated: 2008-08-14

Locations

1 site across 1 country: United States