NCT00104637

Sildenafil for Chronic Obstructive Pulmonary Disease

A Double-blind, Placebo-controlled, Crossover Study of Sildenafil in Patients With Chronic Obstructive Pulmonary Disease

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Kawut, Steven, MD · Individual
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine if sildenafil improves the exercise capacity and lung function of patients with chronic obstructive pulmonary disease.

Detailed description

Patients with chronic obstructive pulmonary disease (COPD) suffer from impaired exercise capacity and quality-of-life, largely related to shortness of breath. Many of the therapies currently available for COPD are aimed at improving these factors. Exercise capacity is limited in part by high blood pressure in the blood vessels in the lungs. Sildenafil, also known as Viagra, is an FDA-approved therapy for male erectile dysfunction. One of its effects is to relax (or open) the lung vessels, thereby lowering the blood pressure in the lungs. We hypothesize that sildenafil will result in an improvement in exercise capacity, quality-of-life, and shortness of breath. Enrolled subjects will receive sildenafil or placebo for 4 weeks followed by exercise tests, breathing tests, and administration of quality-of-life questionnaires. Subjects will then receive placebo or sildenafil (whichever one they did not receive for the first 4 weeks) for another 4 weeks, followed by the same testing.

Conditions

• Pulmonary Disease, Chronic Obstructive
• Emphysema

Interventions

Type	Name	Description
DRUG	sildenafil citrate	sildenafil citrate 25 mg by mouth thrice daily (po tid)
DRUG	Placebo	25 mg po tid

Timeline

• Start date: 2005-02-01
• Primary completion: 2008-11-01
• Completion: 2008-11-01
• First posted: 2005-03-04
• Last updated: 2012-05-21
• Results posted: 2012-05-21

Locations

1 site across 1 country: United States