NCT04537182

Surgical Compared to Bronchoscopic Lung Volume Reduction in Patients With Severe Emphysema

Surgical Compared to Bronchoscopic Lung Volume Reduction in Patients With Severe Emphysema: an International Multi-center Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Isabelle Opitz, Professor, MD · Academic / Other
• Sex: All
• Age: 30 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The investigators plan to perform a randomized controlled trial that compares bilateral lung volume reduction surgery (LVRS) with bronchoscopic lung volume reduction (BLVR) using endobronchial valves in terms of efficacy and patient safety.

Detailed description

Advanced lung emphysema has a considerable impact on quality of life in patients with chronic obstructive pulmonary disease. There are positive reports of surgical as well as bronchoscopic volume reduction in selected patients, but data comparing LVRS and BLVR is unfortunately lacking to date. The investigators therefore anticipate that their study will make an important contribution to the worldwide efforts in better understanding selection and management of surgical and bronchoscopic treatment of emphysema patients and that it will be of high public interest.

Conditions

• Emphysema

Interventions

Type	Name	Description
PROCEDURE	Lung volume reduction surgery	Lung volume reduction by surgery
PROCEDURE	Bronchoscopic lung volume reduction with valves	Lung volume reduction with endobronchial valves.

Timeline

• Start date: 2020-09-01
• Primary completion: 2028-03-01
• Completion: 2028-03-01
• First posted: 2020-09-03
• Last updated: 2024-05-08

Locations

6 sites across 4 countries: Austria, Belgium, Denmark, Switzerland