NCT00528944

Single-Breath Measurement Underestimates Ventilatory Volume According to Emphysema Severity

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 73 (actual)
• Sponsor: Columbia University · Academic / Other
• Sex: All
• Age: 18 Years – 81 Years
• Healthy volunteers: Accepted

Summary

Although single breath helium (He) dilution measurement (VASB) is currently used in pulmonary function laboratories to assess functional alveolar volume and diffusing capacity for carbon monoxide, the extent to which VASB reflects ventilatory and thoracic volume has not been prospectively determined in emphysema. We hypothesized that VASB underestimates rebreathe helium dilution volume (VARB), and plethysmographic volume (VApleth) as clinical and physiologic severity of emphysema increases.

Detailed description

VASB, VARB, and VApleth were measured in 52 consecutive stable outpatients with clinical and radiographic emphysema. Thirteen patients with an obstructive ventilatory defect without emphysema (OVD) and 18 normal controls were similarly studied. All subjects underwent spirometry followed by whole body plethysmography and He dilution volume measurements; VASB and VARB order was randomized.

Conditions

• Emphysema

Timeline

• Start date: 2006-01-01
• Primary completion: 2008-07-01
• Completion: 2008-07-01
• First posted: 2007-09-14
• Last updated: 2015-07-07

Locations

1 site across 1 country: United States