| Not Yet Recruiting | Therapeutic ID93 + GLA-SE Vaccination in Participants With Rifampicin-Susceptible Pulmonary TB NCT06205589 | Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections | Phase 2 |
| Recruiting | 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) in Tuberculosis Patients NCT07077213 | Children's Hospital Medical Center, Cincinnati | — |
| Not Yet Recruiting | Digital Health Intervention to Improve TPT Uptake NCT07313995 | Arba Minch University | N/A |
| Recruiting | Safety and Efficacy of Ear Acupuncture for Antituberculosis Drug-Related Nausea and Vomiting NCT07271225 | Indonesia University | N/A |
| Recruiting | DoseTB-individualised Dosing by Model-informed Precision Dosing for Pulmonary Tuberculosis NCT06585358 | Karolinska Institutet | — |
| Recruiting | Program for Rifampicin-Resistant Disease With Stratified Medicine for Tuberculosis NCT06441006 | University of California, San Francisco | Phase 2 / Phase 3 |
| Not Yet Recruiting | Short-Course Regimen With Bedaquiline, Moxifloxacin and Pyrazinamide for Early Bactericidal Activity in Drug-S NCT07129629 | Shanghai Pulmonary Hospital, Shanghai, China | Phase 2 |
| Recruiting | Blood Tuberculosis DNA Levels to Monitor Tuberculosis Treatment NCT06845618 | University of Oxford | — |
| Recruiting | ID93+GLA-SE Vaccine Against Tuberculosis in Older Adults Aged 55-74 NCT06714513 | Quratis Inc. | Phase 1 |
| Not Yet Recruiting | Evaluating Urine Isoniazid Testing to Detect Nonadherence to Tuberculosis Medications in India NCT06526221 | Tufts University | N/A |
| Recruiting | Shortened Regimen for Drug-susceptible TB in Children NCT06253715 | Johns Hopkins University | Phase 3 |
| Recruiting | Characterization of Tuberculosis Associated Lung Fibrosis and Respiratory Impairment, and Prevention Using Dox NCT06477185 | Makerere University | Phase 2 |
| Enrolling By Invitation | Post TB Sequelae Study NCT06744179 | International Centre for Diarrhoeal Disease Research, Bangladesh | — |
| Not Yet Recruiting | A Short Regimen for Rifampicin-resistant Isoniazid-susceptible TB NCT06526039 | Taipei Medical University WanFang Hospital | Phase 3 |
| Not Yet Recruiting | Comparative Efficacy of CUS, CXR and CAD in TB Diagnosis in LMIC NCT06409780 | University of Bari | N/A |
| Not Yet Recruiting | Performance of Xpert MTB/RIF and XDR Assay for Diagnosis of Pulmonary Tuberculosis and Resistant Pulmonary TB NCT06392594 | Assiut University | — |
| Recruiting | Pragmatic Optimized Rifampicin Trial NCT06057519 | Radboud University Medical Center | Phase 3 |
| Recruiting | Conventional Bronchoscope With BAL vs. Thin Bronchoscope With BW to Diagnose Pulmonary TB NCT06159023 | Pusan National University Hospital | N/A |
| Active Not Recruiting | Ultra-Short Course Bedaquiline, Clofazimine, Pyrazinamide and Delamanid Versus Standard Therapy for Drug-Susce NCT05556746 | Brigham and Women's Hospital | Phase 2 |
| Active Not Recruiting | Short-course Regimens for the Treatment of Pulmonary Tuberculosis NCT05766267 | Centers for Disease Control and Prevention | Phase 2 / Phase 3 |
| Unknown | BTZ-043 Dose Evaluation in Combination and Selection NCT05926466 | Michael Hoelscher | Phase 2 |
| Completed | The INSTITUT Study Tuberculosis Nutritional Support NCT06084715 | Boston Medical Center | — |
| Completed | Bronchoscopic Role in Early Detection of Endobronchial Tuberculosis in Suspected Pulmonary Tuberculosis Patien NCT07350356 | Ain Shams University | — |
| Completed | Pharmacist-Led Intervention to Improve TB Treatment Adherence NCT06608069 | Universiti Sains Malaysia | N/A |
| Unknown | Clinical Evaluation of the NanoDetect-TB Mycobacterium Tuberculosis Detection Kit for the Diagnosis of Tubercu NCT05981495 | NanoPin Technologies, Inc. | — |
| Completed | Effect of Breathing Exercise on Fatigue in Patients With Pulmonary Tuberculosis NCT06171646 | Sema Aytaç, PhD | N/A |
| Unknown | The BLAST- 1 Trial - Cephalexin+Amoxicillin-clavulanate for Tuberculosis NCT05664568 | Western Sydney Local Health District | Phase 2 |
| Recruiting | Tuberculosis Cohort Avicenne Hospital NCT05539014 | Assistance Publique - Hôpitaux de Paris | — |
| Recruiting | Optimizing(O) RIfapentine-based(RI) Regimen and shortENing(EN) the Treatment of Drug-sensitive Tuberculosis(T) NCT05401071 | Huashan Hospital | Phase 2 / Phase 3 |
| Suspended | Drug Exposure and Safety of a Shorter Tuberculosis Treatment Based on High-Dose Rifampicin and Pyrazinamide NCT04694586 | University Hospital, Linkoeping | Phase 2 |
| Completed | Safety and Efficacy of RUTI® With the Standard of Treatment for Tuberculosis NCT05455112 | Archivel Farma S.L. | Phase 2 |
| Not Yet Recruiting | Sitafloxacin-containing Regimens for Shortening Tuberculosis Treatment NCT05454345 | First Affiliated Hospital of Zhejiang University | Phase 3 |
| Withdrawn | Azacytidine During Anti-tuberculosis Therapy NCT03941496 | Andrew Dinardo | Phase 1 / Phase 2 |
| Unknown | TuBerculosis Viability Interregional Study and Agreement on Biological Tests NCT04968886 | Assistance Publique - Hôpitaux de Paris | — |
| Active Not Recruiting | Linezolid Dosing Strategies in Drug-Resistant TB NCT05007821 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 2 |
| Completed | Collision of Three Global Pandemics: the Effect of Tuberculosis and HIV on the Epidemiological, Clinical, Viro NCT05268380 | University of Namibia | — |
| Recruiting | A Systemic Screening for TB Disease in High-risk Groups in Barcelona NCT06706596 | Fundació Institut Germans Trias i Pujol | — |
| Unknown | A Retrospective Cohort Study to Develop Markers for TB Severity and Treatment Progress NCT05477966 | Jae-Joon Yim | — |
| Completed | Effect of Integrating Traditional Tuberculosis Care With Modern Health Care on Case Detection NCT05236452 | Bahir Dar University | N/A |
| Completed | A Phase 1, Drug-Drug Interaction Study of TBAJ-876 in Healthy Adults NCT05526911 | Global Alliance for TB Drug Development | Phase 1 |
| Completed | Pharmacokinetics of Ethionamide and Ethionamide Sulfoxide in Patients Established on Treatment for Tuberculosi NCT05258877 | BioVersys AG | — |
| Recruiting | Clinic-based Versus Hotspot-focused Active TB Case Finding NCT05285202 | Johns Hopkins University | N/A |
| Completed | EBA, Safety and Tolerability of Sanfetrinem Cilexetil NCT05388448 | TASK Applied Science | Phase 2 |
| Completed | Tuberculosis - Learning the Effect of Parasites and Reinforcing Diets NCT05048485 | Boston Medical Center | — |
| Unknown | Childhood TB Sequel NCT05325125 | London School of Hygiene and Tropical Medicine | — |
| Unknown | Four Months Moxifloxacin Containing Daily Regimen Study Among New Pulmonary Tuberculosis Patients NCT05047055 | Tuberculosis Research Centre, India | — |
| Completed | Human-centered Design and Communities of Practice to Improve Home-based Tuberculosis Contact Investigation in NCT05640648 | Yale University | N/A |
| Completed | INSTI's For The Management of HIV-associated TB NCT04734652 | Centre for the AIDS Programme of Research in South Africa | Phase 2 |
| Unknown | Efficacy of Metformin for Sputum Conversion in Patients With Active Pulmonary Tuberculosis NCT05215990 | Mahidol University | Phase 1 / Phase 2 |
| Completed | Validating the Use of Blood Transcriptomic Signatures for the Diagnosis of Active Pulmonary Tuberculosis NCT04995406 | BioMérieux | — |
| Completed | Epidemiologic Study to Assess the IGRA Positivity in Populations With a High TB Burden NCT05190146 | Gates Medical Research Institute | — |
| Recruiting | Prevalence of Latent Tuberculosis Infection in Health-care Workers and Students NCT05756582 | Eleonora Nucera | — |
| Completed | A Clinical Risk Score for Early Management of TB in Uganda NCT05122624 | Johns Hopkins Bloomberg School of Public Health | N/A |
| Completed | Absorption, Elimination and Safety of 14C-labeled Radioactive BTZ-043, a New Compound in TB Treatment NCT04874948 | Michael Hoelscher | Phase 1 |
| Completed | Airborne Preventive Measures to Reduce New TB Infections in Household Contacts NCT04938596 | Pontificia Universidad Catolica de Chile | N/A |
| Completed | Clinical Trial to Investigate Therapeutic Vaccine (RUTI) Against Tuberculosis (TB) NCT04919239 | Archivel Farma S.L. | Phase 2 |
| Completed | Evaluation of a Rapid Point-of-Care Serological Triage Test for Active TB NCT04752592 | Norwegian Institute of Public Health | N/A |
| Completed | A Trial to Evaluate the Male Reproductive Safety of Pretomanid in Adult Male Participants With Drug Resistant NCT04179500 | Global Alliance for TB Drug Development | Phase 2 |
| Active Not Recruiting | Cardiopulmonary Function and Quality of Life in Pulmonary Tuberculosis NCT04844502 | Universidade Federal do Rio de Janeiro | N/A |
| Terminated | PredictEndTB Signature for Individualizing Treatment in Multidrug-Resistant Tuberculosis NCT04783727 | Research Center Borstel | N/A |
| Unknown | Adjunctive Acetylsalicylic Acid and Ibuprofen for Tuberculosis NCT04575519 | Fundació Institut Germans Trias i Pujol | Phase 2 |
| Completed | Study to Evaluate Safety, Tolerability, and the PK Profile of TBI-223 in Healthy Subjects NCT04865536 | Global Alliance for TB Drug Development | Phase 1 |
| Completed | Treating Tuberculosis With the Lipid Lowering Drug Atorvastatin in Nigeria(ATORvastatin in Pulmonary TUBerculo NCT04721795 | Obafemi Awolowo University Teaching Hospital | Phase 2 / Phase 3 |
| Completed | DIAGNOSIS of PULMONARY TUBERCULOSIS Through HUMAN BREATH (TBENOSE) NCT04682990 | University of Rome Tor Vergata | N/A |
| Completed | Vitamin D Supplementation Effect In Children With Pulmonary Tuberculosis Treatment NCT05073965 | Universitas Padjadjaran | N/A |
| Unknown | Point-of-care Triage Test for Active Tuberculosis NCT04232618 | University of Stellenbosch | — |
| Not Yet Recruiting | Treatment Shortening of Drug-Sensitive Pulmonary Tuberculosis Using High Dose Rifampicin (Hi-DoRi-3) NCT04485156 | Seoul National University Hospital | Phase 3 |
| Recruiting | Atorvastatin to Reduce Inflammation After Tuberculosis Treatment Completion NCT04147286 | University of Cape Town | Phase 2 / Phase 3 |
| Completed | Evaluate Safety, Tolerability, PK of TBAJ-876 in Healthy Adults NCT04493671 | Global Alliance for TB Drug Development | Phase 1 |
| Active Not Recruiting | Evaluation of the Efficacy and Safety of a 4-month Daily Regimen (2HZPM/2HPM) for Treatment of Pulmonary TB NCT04856644 | Kaohsiung Veterans General Hospital. | Phase 3 |
| Completed | POC Strategies to Improve TB Care in Advanced HIV Disease NCT04122404 | University of Southern Denmark | N/A |
| Withdrawn | Novel Triple-dose Tuberculosis Retreatment Regimens: How to Overcome Resistance Without Creating More NCT03862248 | Institute of Tropical Medicine, Belgium | Phase 3 |
| Completed | A Study to Validate and Improve an Automated Image Analysis Algorithm to Detect Tuberculosis in Sputum Smear S NCT05899400 | Diascopic, LLC | — |
| Completed | Xpert MTB/XDR Clinical Evaluation Trial NCT03728725 | Foundation for Innovative New Diagnostics, Switzerland | — |
| Unknown | PCR Techniques of Dried Sputum Using a Spotcard NCT04055584 | University Medical Center Groningen | — |
| Unknown | Evaluation of CRISPR-based Test for the Rapid Identification of TB in Pulmonary Tuberculosis Suspects NCT04074369 | Huashan Hospital | — |
| Withdrawn | VDOT and Mobile Payments in Cambodia NCT03547479 | University of Southern California | N/A |
| Completed | Clinical Evaluation of the Truenat Point-of-care Tuberculosis Diagnostic Test NCT03712709 | Foundation for Innovative New Diagnostics, Switzerland | — |
| Completed | Adjunctive NAC in Adult Patients With Pulmonary Tuberculosis NCT03702738 | The Aurum Institute NPC | Phase 2 |
| Completed | Study to Evaluate the Safety, Tolerability and Pharmacokinetics of PBTZ169 in Multiple Dosing NCT03776500 | Innovative Medicines for Tuberculosis | Phase 1 |
| Completed | Study to Evaluate H56:IC31 in Preventing Rate of TB Recurrence NCT03512249 | International AIDS Vaccine Initiative | Phase 2 |
| Completed | A Phase 1 Study to Evaluate Safety, Tolerability, and Pharmacokinetics of TBI-223 in Healthy Adults NCT03758612 | Global Alliance for TB Drug Development | Phase 1 |
| Withdrawn | Bronchial Washings in Sputum Scarce Cases of Pulmonary Tuberculosis NCT03732014 | Faisal Faiyaz Zuberi | — |
| Unknown | A Pragmatic Randomised Study to Optimise Screening, Prevention and Care for Tuberculosis in Malawi NCT03519425 | Liverpool School of Tropical Medicine | N/A |
| Completed | GeneXpert Performance Evaluation for Linkage to Tuberculosis Care NCT03044158 | University of California, San Francisco | N/A |
| Completed | Trial to Evaluate the Efficacy, Safety and Tolerability of BPaMZ in Drug-Sensitive (DS-TB) Adult Patients and NCT03338621 | Global Alliance for TB Drug Development | Phase 2 / Phase 3 |
| Completed | Acceptability and Feasibility of Home-based TB Testing NCT04973371 | Foundation for Professional Development (Pty) Ltd | N/A |
| Completed | A Single Ascending Dose Study of BTZ043 NCT03590600 | Michael Hoelscher | Phase 1 |
| Unknown | Rifampicin vs Rifabutin in HIV/AIDS Patients Combined With Tuberculosis NCT03478033 | Shanghai Public Health Clinical Center | N/A |
| Unknown | Study on the Management Model of "Home Treatment" for Tuberculosis Patients NCT03967353 | Beijing Chest Hospital | N/A |
| Completed | Two-month Regimens Using Novel Combinations to Augment Treatment Effectiveness for Drug-sensitive Tuberculosis NCT03474198 | University College, London | Phase 2 / Phase 3 |
| Unknown | AI-based System for Lung Tuberculosis Screening: Diagnostic Accuracy Evaluation NCT05889364 | Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department | — |
| Completed | Azithromycin as Host-directed Therapy for Pulmonary Tuberculosis NCT03160638 | University Medical Center Groningen | Phase 2 |
| Completed | Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Ex-vivo Antitubercular Activity of PBTZ169 Fo NCT03423030 | Innovative Medicines for Tuberculosis | Phase 1 |
| Completed | Various Doses and Durations of Linezolid Plus Bedaquiline & Pretomanid in Participants With Drug Resistant Tub NCT03086486 | Global Alliance for TB Drug Development | Phase 3 |
| Completed | Effect of Smoking Cessation on Tuberculosis Treatment Outcomes NCT04848246 | Dow University of Health Sciences | N/A |
| Completed | Nanodisk-MS Assay for the Diagnosis of Active Pulmonary and Extrapulmonary Tuberculosis in Hospitalized Patien NCT03271567 | Chinese University of Hong Kong | — |
| Completed | Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Sutezolid NCT03199313 | Global Alliance for TB Drug Development | Phase 1 |
| Unknown | TB Sequel: Pathogenesis and Risk Factors of Long-term Sequelae of Pulmonary TB NCT03251196 | The Aurum Institute NPC | — |
| Terminated | Prevention of Tuberculosis in Prisons NCT03028129 | Federal University of Mato Grosso | Phase 4 |
| Completed | A Phase 1 Study to Evaluate Safety, Tolerability, PK, and PK Interactions of TBA-7371 NCT03199339 | Global Alliance for TB Drug Development | Phase 1 |
| Completed | Early Bactericidal Activity of Rifampin + Meropenem + Amoxicillin/Clavulanate in Adults With Pulmonary TB NCT03174184 | Johns Hopkins University | Phase 2 |
| Terminated | Treating Tuberculosis Wasting With a High-protein Supplement NCT03302949 | University of Aarhus | N/A |
| Unknown | Early Diagnosis of Active Tuberculosis Using Ultra Low-dose Chest CT NCT03220464 | Seoul National University Hospital | N/A |
| Unknown | Personalization of AntiTB Treatment: Evaluation of Pharmacological Determinants of Treatment Response NCT03416309 | University of Turin, Italy | — |
| Terminated | Efficacy and Safety of Intravenous Treatment of Tuberculosis NCT04150367 | Yuria-Pharm | — |
| Completed | Pragmatic Clinical Trial for a More Effective Concise and Less Toxic MDR-TB Treatment Regimen(s) NCT02589782 | Medecins Sans Frontieres, Netherlands | Phase 2 / Phase 3 |
| Unknown | RIPE vs RIPE Plus N-acetylcysteine in Patients With HIV/TB Co-infection NCT03281226 | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado | Phase 2 |
| Completed | Microbiome in Pulmonary Tuberculosis, Non-tuberculous Mycobacterial Pulmonary Diseases, Lung Cancer and Hemopt NCT04079400 | Gachon University Gil Medical Center | — |
| Unknown | Evaluation of 11C-acetate PET Imaging as a Novel Approach to Detecting Pathology in Pulmonary TB NCT02972697 | National University Hospital, Singapore | Phase 1 |
| Unknown | Evaluation of PET/MRI Using a Somatostatin Analog Tracer as a Novel Approach to Detecting Pathology in High Ri NCT02967666 | National University Hospital, Singapore | Phase 1 |
| Completed | Study of TB Lesions Obtained in Therapeutical Surgery NCT02715271 | Fundació Institut Germans Trias i Pujol | — |
| Unknown | Shortened Regimens for Drug-susceptible Pulmonary Tuberculosis NCT02901288 | Beijing Chest Hospital | Phase 4 |
| Unknown | A New Treatment for Primary Smear-positive Pulmonary Tuberculosis With Interleukin-2 NCT04766307 | Beijing Chest Hospital | Phase 4 |
| Unknown | Probe Melting Technology for Rapid Detection of Drug Resistant Tuberculosis NCT02776150 | Beijing Hospital | — |
| Completed | Accuracy and Feasibility of Xpert Ultra NCT03072576 | Foundation for Innovative New Diagnostics, Switzerland | — |
| Completed | Integrated Discovery and Development of Innovative TB Diagnostics NCT06624501 | Harvard University Faculty of Medicine | — |
| Unknown | IGRA and Mantoux Response in Children With Suspected Latent or Active TB Infection NCT02653404 | University of Siena | — |
| Unknown | Diagnostic Trial to Validate the Use of the E-Nose in Pulmonary TB NCT02768909 | Universidad Central de Venezuela | N/A |
| Completed | Optimization of the TB Treatment Regimen Cascade NCT02153528 | Damien Foundation | Phase 3 |
| Completed | Evaluation of SQ109, High-dose Rifampicin, and Moxifloxacin in Adults With Smear-positive Pulmonary TB in a MA NCT01785186 | Michael Hoelscher | Phase 2 |
| Unknown | Safety and Efficacy of Blocking IL-4 With Pascolizumab in Patients Receiving Standard Therapy for Pulmonary Tu NCT01638520 | National University Hospital, Singapore | Phase 2 |
| Unknown | Reintroduction Regimens After Hepatitis During Anti-tuberculosis Treatment NCT01395654 | National Taiwan University Hospital | Phase 4 |
| Terminated | Utility of MODS for Diagnosis of MDR-TB and Second-Line Antituberculous Drug Susceptibility Testing in Mali NCT01381757 | National Institute of Allergy and Infectious Diseases (NIAID) | — |
| Unknown | Feasibility of a Lateral Flow Urine LAM Test for Diagnosis of Tuberculosis in South Africa NCT01693224 | Tuberculosis Clinical Diagnostics Research Consortium | N/A |
| Unknown | Feasibility of a Lateral Flow Urine Lipoarabinomannan (LAM) Test for Diagnosis of Tuberculosis NCT01525134 | Tuberculosis Clinical Diagnostics Research Consortium | N/A |
| Completed | Early Bactericidal Activity (EBA) of SQ109 in Adult Subjects With Pulmonary TB NCT01218217 | Michael Hoelscher | Phase 2 |
| Completed | Pharmacokinetics of Anti-tuberculosis Drugs in Gastrectomized Patients NCT01364324 | National Cancer Center, Korea | — |
| Completed | Pharmacokinetics, Safety and Tolerability of Escalating Rifapentine Doses in Healthy Volunteers NCT01162486 | Johns Hopkins University | Phase 1 |
| Completed | Clinical Analysis of the Patients With Cavitary Pulmonary TB and Endobronchial TB in the PPM-UUH Cohort NCT03822156 | University of Ulsan | — |
| Completed | Cost-effectiveness of Two Forms of DOTS in a Demonstration Area of the DOTS Strategy in Colombia NCT01945905 | Fundación FES | N/A |
| Completed | Replacement of Vitamin D in Patients With Active Tuberculosis NCT01130311 | Aga Khan University | N/A |
| Completed | A Trial to Evaluate OPC 67683 in Participants With Pulmonary Sputum Culture-positive, Multidrug-resistant Tube NCT00685360 | Otsuka Pharmaceutical Development & Commercialization, Inc. | Phase 2 |
| Completed | Co-Infection of NTM in Patients With Smear Positive Pulmonary TB NCT00567151 | Seoul National University Hospital | — |
| Completed | MDR TB, Levofloxacin, Multi-Drug-Resistant Pulmonary Tuberculosis NCT00495339 | Sanofi | Phase 4 |
| Completed | Trial of Adjunctive Vitamin D in Tuberculosis Treatment NCT00419068 | Barts & The London NHS Trust | Phase 3 |
| Completed | Study of Interferon-Gamma in the Complex Treatment of Patients Infected With HIV and Tuberculosis NCT05065905 | SPP Pharmaclon Ltd. | Phase 1 / Phase 2 |
| Completed | The Effectiveness of Health Facility-based and Community-based Care for Tuberculosis NCT00939419 | University of Leeds | Phase 4 |
| Completed | TBTC Study 27: Moxifloxacin vs Ethambutol for TB Treatment NCT00140309 | Centers for Disease Control and Prevention | Phase 2 |
| Completed | Diagnosing Tuberculosis in HIV Infected Children in Peru NCT00054769 | National Institute of Allergy and Infectious Diseases (NIAID) | — |
| Completed | Pilot Randomized Study of Paromomycin (Aminosidine) vs Streptomycin for Uncomplicated Pulmonary Tuberculosis NCT00004444 | FDA Office of Orphan Products Development | N/A |