NCT01364324

Pharmacokinetics of Anti-tuberculosis Drugs in Gastrectomized Patients

Absorption of Anti-tuberculosis Drugs and Its Effect to Treatment Response in Gastrectomized Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 40 (actual)
• Sponsor: National Cancer Center, Korea · Other Government
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the effect of gastrectomy on pharmacokinetic profile of first-line anti-tuberculosis drugs in patients with pulmonary tuberculosis (TB).

Detailed description

Gastrectomy is a well-known risk factor for TB. Also, there were some reports about malabsorption of anti-TB drugs in the gastrectomized patients. However, pharmacokinetics of recently used first line anti-TB drugs in the gastrectomized patients have not been well evaluated simultaneously. Therefore, the investigators aim to evaluate the effect of gastrectomy on pharmacokinetic profile of first-line anti-TB drugs in patients with pulmonary TB through this study.

Conditions

• Tuberculosis
• Tuberculosis, Pulmonary
• Early Gastric Cancer

Interventions

Type	Name	Description
DRUG	standard first line anti-TB drugs	We will perform pharmacokinetic study in gastrectomy and non-gastrectomy group, to evaluate the effect of gastrectomy on pharmacokinetic profile of first-line anti-TB drugs in patients with TB

Timeline

• Start date: 2010-09-01
• Primary completion: 2020-06-01
• Completion: 2020-06-01
• First posted: 2011-06-02
• Last updated: 2020-09-25

Locations

1 site across 1 country: South Korea