Clinical Trials Directory

Trials / Conditions / Spinal Muscular Atrophy

Spinal Muscular Atrophy

148 registered clinical trials studyying Spinal Muscular Atrophy27 currently recruiting.

StatusTrialSponsorPhase
Not Yet RecruitingASsessing The REAl-world Safety & Effectiveness of Spinal Muscular Atrophy Participants Treated With Intrathec
NCT07448610
Novartis PharmaceuticalsPhase 4
Not Yet RecruitingA Study to Learn About Salanersen's (BIIB115) Effects on Movement and Its Safety in Participants Aged 15 to 60
NCT07444476
BiogenPhase 3
RecruitingEffects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease
NCT07478172
University of Missouri-ColumbiaN/A
RecruitingExploring the Physiologic, Pharmacodynamic, and Clinical Responses of Skeletal Muscle in Patients With Spinal
NCT06532474
St. Jude Children's Research Hospital
RecruitingA Study to Evaluate How Apitegromab Works in Subjects Who Are Less Than 2 Years Old and Have Spinal Muscular A
NCT07047144
Scholar Rock, Inc.Phase 2
RecruitingCharacterizing Perceived Physical Fatigability in Nusinersen-treated SMA
NCT06955897
Columbia University
Enrolling By InvitationA Long-term Follow-up Study Evaluating Intravenous Injection of EXG001-307 in Patients With Type 1 SMA
NCT06588803
Guangzhou Jiayin Biotech Ltd
RecruitingA Registry Based Randomized-Controlled Trial of an Upper Limb Exergaming Intervention for Children and Adolesc
NCT06396325
Maryam Oskoui, MD, MSc, FRCPC, FAANN/A
RecruitingAn Open Label Study of Gene Therapy Product (Vesemnogene Lantuparvovec) in Spinal Muscular Atrophy
NCT06288230
Lantu BiopharmaPhase 1 / Phase 2
Enrolling By InvitationDevelopment and Validation of the FBIndex to Determine the Risk of Falls for Patients With Neuromuscular Disor
NCT06605612
LMU Klinikum
RecruitingCharacterization of New Phenotypes of Patients With Spinal Muscular Atrophy Treated With SMN Restoring Therapy
NCT06321965
Hospices Civils de LyonN/A
Active Not RecruitingAcceptability, Feasibility, Safety and Efficacy of a Optimized Rehabilitation Program for Treated Patients Wit
NCT06419322
University of OxfordN/A
Active Not RecruitingSpinal Cord Stimulation for the Treatment of Motor Deficits in People With Spinal Muscular Atrophy - Upper Lim
NCT06300996
Marco CapogrossoN/A
RecruitingRespiratory Functions, Thoracoabdominal Movements and Exercise Capacity in Neuromuscular Diseases
NCT06756633
Lokman Hekim University
RecruitingHigh-intensity Interval Training in Patients With Spinal Muscular Atrophy
NCT06368076
Rigshospitalet, DenmarkN/A
RecruitingA Review of the Management and Outcomes of Children With SMA in the West Midlands During 2017-2022
NCT05994950
Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
CompletedSafety and Usability of a Robotic Gait Device for Children and Adolescents With Neurological or Neuromuscular
NCT06167954
MarsiBionicsN/A
RecruitingStudy of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy
NCT05866419
Alcyone Therapeutics, IncN/A
RecruitingSpinal Muscular Atrophy Neonatal Screening Program
NCT06310421
IRCCS Burlo Garofolo
Active Not RecruitingSafety and Efficacy of NMD670 in Ambulatory Adult Patients With Type 3 Spinal Muscular Atrophy
NCT05794139
NMD Pharma A/SPhase 2
UnknownDevelopment of a Multidisciplinary Network for Clinical and Laboratory Research for SMA
NCT05866939
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
UnknownMotor Function and Activity of Daily Life in Spinal Muscular Atrophy
NCT05931211
National Taiwan University Hospital
Active Not RecruitingLong-Term Safety & Efficacy of Apitegromab in Patients With SMA Who Completed Previous Trials of Apitegromab
NCT05626855
Scholar Rock, Inc.Phase 3
UnknownMAP THE SMA: a Machine-learning Based Algorithm to Predict THErapeutic Response in Spinal Muscular Atrophy
NCT05769465
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RecruitingEvaluation of Safety and Efficacy of Gene Therapy Drug in the Treatment of Spinal Muscular Atrophy (SMA) Type
NCT05824169
GeneCradle IncPhase 1 / Phase 2
CompletedExploratory Study of Respiratory Bacterial Infections or Superinfections and Colonizations in Patients With Sp
NCT05712330
Centre Hospitalier Universitaire, AmiensN/A
CompletedPhase IIIb, Open-label, Multi-center Study to Evaluate Safety, Tolerability and Efficacy of OAV101 Administere
NCT05386680
Novartis PharmaceuticalsPhase 3
CompletedUltrasound-assisted or Landmark-based Intrathecal Administration of Nusinersen in Adult Patients With Spinal M
NCT05644899
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
CompletedMechanisms and Treatment of Exercise Intolerance and Persistent Fatigue in Spinal Muscular Atrophy
NCT05518773
Columbia University
RecruitingLong Term Trajectories of SMA Patients Receiving or Not Disease-modifying Treatments
NCT05768048
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Active Not RecruitingRisdiplam in Patients With Spinal Muscular Atrophy Previously Treated With Nusinersen
NCT05522361
Clinic for Special ChildrenPhase 4
CompletedQuality of Life and Participation of the Adult with Spinal Muscular Atrophy in France
NCT05366465
Hospices Civils de Lyon
UnknownSpinal Muscular Atrophy on Wheels, Using Power Mobility
NCT05589987
University of Castilla-La ManchaN/A
UnknownReliability and Validity of the Turkish Version of the PedsQL 3.0 Neuromuscular Module for 2-to 4- Year-old
NCT05539456
Istanbul Medipol University Hospital
UnknownMyotonometer Intra- and Inter Examiner Reliability on Spinal Muscular Atrophy
NCT05521217
Istanbul Medipol University Hospital
UnknownLongitudinal Data Collection in Pediatric and Adult Patients With Spinal Muscular Atrophy in Latin America
NCT05475691
Hospital Israelita Albert Einstein
Active Not RecruitingA Study to Evaluate the Efficacy and Safety of Taldefgrobep Alfa in Participants With Spinal Muscular Atrophy
NCT05337553
Biohaven Pharmaceuticals, Inc.Phase 3
UnknownSchulze Muscular Dystrophy Ability Clinical Study
NCT05409079
AbiliTech Medical Inc.N/A
CompletedReal-World Use of Novel Treatments in Patients With Spinal Muscular Atrophy (SMA): A Multi-Site Retrospective
NCT06178393
Novartis Pharmaceuticals
Active Not RecruitingCOMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis
NCT05035823
Synchron Medical, Inc.N/A
RecruitingHippotherapy in Children With Spinal Muscular Atrophy
NCT05341453
Charles University, Czech RepublicN/A
WithdrawnSWITCH II Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis
NCT05041114
Synchron Medical, Inc.N/A
CompletedEfficacy and Safety of Apitegromab in Patients With Later-Onset Spinal Muscular Atrophy Treated With Nusinerse
NCT05156320
Scholar Rock, Inc.Phase 3
Active Not RecruitingLong-term Follow-up Study of Risdiplam in Participants With Spinal Muscular Atrophy (SMA)
NCT05232929
Genentech, Inc.Phase 4
CompletedA Study to Assess the Clinical Validity of Konectom™ in Adults Living With Neuromuscular Disorders
NCT05109637
BiogenN/A
CompletedImplementation of FEES in Spinal Muscle Atrophy
NCT04773470
University of GiessenN/A
CompletedStudy of the Functional Effects of Nusinersen in 5q-spinal Muscular Amyotrophy Adults (SMA Type 2 or 3 Forms)
NCT04576494
CHU de ReimsN/A
Active Not RecruitingA Study to Learn About the Effect of Higher Doses of Nusinersen (BIIB058) Given as Injections to Participants
NCT05067790
BiogenPhase 3
UnknownAntisense Oligonucleotide for Spinal Muscular Atrophy
NCT05187260
First Affiliated Hospital of Fujian Medical University
RecruitingOutpatient Rehabilitation Intervention for Young Children With SMA
NCT05638750
Holland Bloorview Kids Rehabilitation HospitalN/A
Active Not RecruitingPediatric Powered Wheelchair Standing Devices: An Exploratory Study
NCT05117827
Grand Valley State UniversityN/A
UnknownPublic AttitudesTowards SMA and DMD Awareness, Newborn and Carrier Screening and Physiotherapy Practices
NCT05110885
Bahçeşehir University
CompletedInvestigating NMJ Defects in SMA Following Central and Peripheral SMN Restoration
NCT05219487
Bakri Elsheikh
CompletedCharacterization of the Postural Habits of Wheelchair Users Analysis of the Acceptability of International Rec
NCT04335942
Assistance Publique - Hôpitaux de ParisN/A
CompletedSafety and Efficacy of Intravenous OAV101 (AVXS-101) in Pediatric Patients With Spinal Muscular Atrophy (SMA)
NCT04851873
Novartis PharmaceuticalsPhase 3
UnknownPersonalized Medicine for SMA: a Translational Project
NCT05779956
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
UnknownSMN Circular RNAs as Potential New Targets and Biomarkers for SMA
NCT05760209
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Active Not RecruitingOutcome Measures and Biomarkers in a Cohort of Spinal Muscular Atrophy Type III/ IV Patients
NCT04690998
Assistance Publique Hopitaux De MarseilleN/A
Active Not RecruitingQuantification of Motor Function in Infants With Spinal Muscular Atrophy Treated With Innovative Therapies
NCT04833348
Assistance Publique - Hôpitaux de ParisN/A
UnknownPrenatal Carrier Screening for Spinal Muscular Atrophy Among Thai Pregnant Women
NCT04859179
Mahidol University
UnknownRespiratory Muscle Training in Patients With Spinal Muscular Atrophy (SMA).
NCT05632666
UMC UtrechtN/A
CompletedResponsiveness and Validation Study of MFM-32 in SMA Patients Treated With Nusinersen
NCT04602195
Hospices Civils de Lyon
UnknownResponsiveness and Validation Study of MFM-20 in SMA Patients Treated With Nusinersen
NCT04644393
Hospices Civils de Lyon
CompletedCharacterization of the Clinical-epidemiological Profile of Patients With SMA5q Types II and III: Observationa
NCT04404764
Hospital Israelita Albert Einstein
RecruitingCuidAME: Longitudinal Data Collection From Patients With Spinal Muscular Atrophy in Spain
NCT07231549
Fundació Sant Joan de Déu
Active Not RecruitingNuroSleeve Powered Brace & Stimulation System to Restore Arm Function
NCT04798378
Thomas Jefferson UniversityN/A
UnknownEvaluation of Therapeutic Response in Spinal Muscular Atrophy Using Multispectral Optoacoustic Tomography (MSO
NCT04262570
University of Erlangen-Nürnberg Medical SchoolN/A
Active Not RecruitingMonitoring to the Evolution of Motor Function in SMA Type II Adults Patients Treated With SPINRAZA®
NCT04159987
Centre Hospitalier Universitaire de NiceN/A
RecruitingFrench Register of Patients With Spinal Muscular Atrophy
NCT04177134
Assistance Publique - Hôpitaux de Paris
UnknownSMN Circular RNAs as Potential Biomarkers for the Therapeutic Response to Nusinersen in Spinal Muscular Atroph
NCT05761262
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
CompletedNewborn Screening for Spinal Muscular Atrophy (SMA) - a Proof of Principle Study Using Anonymised Blood Spots.
NCT05237544
Great Ormond Street Hospital for Children NHS Foundation Trust
CompletedNew Imaging Biomarkers for Muscular Diseases - Multispectral Optoacoustic Imaging in Spinal Muscular Atrophy
NCT04115475
University of Erlangen-Nürnberg Medical SchoolN/A
WithdrawnPulmonary Function Test Changes and Respiratory Muscle Strength Trends in Spinal Muscular Atrophy Patients Rec
NCT04050852
NYU Langone HealthEARLY_Phase 1
RecruitingA Registered Cohort Study on SMA
NCT04010604
Wan-Jin Chen
CompletedThe Burden of Primary Caregivers of Spinal Muscular Atrophy Patients and Their Needs
NCT04228718
Marmara University
CompletedA Drug-drug Interaction Study With Risdiplam Multiple Dose and Midazolam in Healthy Participants
NCT03988907
Hoffmann-La RochePhase 1
CompletedAn Active Treatment Study of SRK-015 in Patients With Type 2 or Type 3 Spinal Muscular Atrophy
NCT03921528
Scholar Rock, Inc.Phase 2
UnknownFeasibility of Virtual Reality in Children With Neuromuscular Disease, Effectiveness of Virtual Reality and Bi
NCT03689660
Merve KurtN/A
Enrolling By InvitationEarly Check: Expanded Screening in Newborns
NCT03655223
RTI International
CompletedAdults With SMA Treated With Nusinersen
NCT04591678
Ohio State University
Active Not RecruitingSpinraza in Adult Spinal Muscular Atrophy
NCT03709784
Washington University School of Medicine
CompletedMotor Unit Number Estimation (MUNE) in Adults With Spinal Muscular Atrophy (SMA)
NCT04139343
Ohio State University
Active Not RecruitingHolter of Movement in Patients with SMA Undergoing Treatment.
NCT04888702
Centre Hospitalier Universitaire de LiegeN/A
CompletedPre-Symptomatic Study of Intravenous Onasemnogene Abeparvovec-xioi in Spinal Muscular Atrophy (SMA) for Patien
NCT03505099
Novartis Gene TherapiesPhase 3
CompletedSun May Arise on SMA : Newborn Screening of Spinal Muscular Atrophy in Belgium
NCT03554343
Centre Hospitalier Régional de la Citadelle
CompletedGenetic Newborn Screening for Cystinosis and Spinal Muscular Atrophy
NCT06027385
Cystinose StiftungN/A
TerminatedStudy of Intrathecal Administration of Onasemnogene Abeparvovec-xioi for Spinal Muscular Atrophy
NCT03381729
Novartis Gene TherapiesPhase 1
CompletedEuropean Registry of Patients With Infantile-onset Spinal Muscular Atrophy
NCT03339830
Institut de Myologie, France
CompletedDevelopment of a Space Exploration Assessment for Children With Spinal Muscular Atrophy
NCT03223051
Centre d'Investigation Clinique et Technologique 805N/A
RecruitingNeonatal Spinal Muscular Atrophy (SMA) Screening
NCT03217578
Kaohsiung Medical University Chung-Ho Memorial Hospital
UnknownNatural History of Types 2 and 3 SMA in Taiwan
NCT03300869
Kaohsiung Medical University Chung-Ho Memorial Hospital
CompletedFat and Glucose Metabolism in Fed and Fasted State in Patients With Low Skeletal Muscle Mass
NCT03970135
Rigshospitalet, DenmarkN/A
CompletedA Study of Risdiplam (RO7034067) in Adult and Pediatric Participants With Spinal Muscular Atrophy
NCT03032172
Hoffmann-La RochePhase 2
CompletedMetabolomics of Children With SMA
NCT04587492
University Medical Centre Ljubljana
CompletedReliability and Validity of the ACTIVE-mini for Quantifying Movement in Infants With Spinal Muscular Atrophy
NCT03808233
University of Texas Southwestern Medical Center
WithdrawnStudy of Feasibility to Reliably Measure Functional Abilities' Changes in Nonambulant Neuromuscular Patients W
NCT02235090
Charitable Foundation Children with Spinal Muscular AtrophyN/A
UnknownProspective Evaluation of Infants With Spinal Muscular Atrophy:
NCT02831296
Massachusetts General Hospital
CompletedA Study of CK-2127107 in Patients With Spinal Muscular Atrophy
NCT02644668
CytokineticsPhase 2
CompletedA Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Risdiplam (RO7034067
NCT02633709
Hoffmann-La RochePhase 1
TerminatedIdentification of a Biomarker Associated With Cis-duplication of the SMN1 Gene
NCT02550691
University Hospital, RouenN/A
CompletedEffects of Standing on Non-Ambulatory Children With Neuromuscular Conditions
NCT02428673
Gillette Children's Specialty HealthcareN/A
CompletedSPACE Trial: Pyridostigmine vs Placebo in SMA Types 2, 3 and 4
NCT02941328
UMC UtrechtPhase 2
CompletedA Study for Participants With Spinal Muscular Atrophy (SMA) Who Previously Participated in Nusinersen (ISIS 39
NCT02594124
BiogenPhase 3
RecruitingImpairments of Neuro-muscular Communication in Motor-Neuron Disease: A Bio-Marker for Early and Personalised D
NCT05663008
University of Dublin, Trinity College
TerminatedA Study to Assess the Safety and Tolerability of Nusinersen (ISIS 396443) in Participants With Spinal Muscular
NCT02462759
BiogenPhase 2
CompletedGenetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases
NCT02532244
Nemours Children's Clinic
CompletedA Study of Multiple Doses of Nusinersen (ISIS 396443) Delivered to Infants With Genetically Diagnosed and Pres
NCT02386553
BiogenPhase 2
CompletedAn Open Label Study of LMI070 (Branaplam) in Type 1 Spinal Muscular Atrophy (SMA)
NCT02268552
Novartis PharmaceuticalsPhase 1 / Phase 2
CompletedA Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Participants With Later-onset Spinal
NCT02292537
BiogenPhase 3
TerminatedA Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Infants With Spinal Muscular Atrophy
NCT02193074
BiogenPhase 3
CompletedWREX Outcome Study
NCT02218593
Nemours Children's Clinic
UnknownNational Registry for Egyptian Pediatric Neuromuscular Diseases
NCT02124616
Ain Shams University
CompletedAn Open-label Safety and Tolerability Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular A
NCT02052791
BiogenPhase 1
UnknownImproving Standards of Care and Translational Research in Spinal Muscular Atrophy (SMA)
NCT03520179
Great Ormond Street Hospital for Children NHS Foundation Trust
CompletedNewborn Screening for Spinal Muscular Atrophy
NCT02123186
National Taiwan University Hospital
UnknownValproate and Levocarnitine in Children With Spinal Muscular Atrophy
NCT01671384
All India Institute of Medical SciencesPhase 3
UnknownReciprocating Gait Orthoses for Paraplegia Patients
NCT02227407
National Taiwan University HospitalN/A
CompletedAt-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurolo
NCT01931644
Sanguine Biosciences
CompletedA Study to Assess the Efficacy, Safety and Pharmacokinetics of Nusinersen (ISIS 396443) in Infants With Spinal
NCT01839656
BiogenPhase 2
CompletedAn Open-label Safety and Tolerability Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular A
NCT01780246
BiogenPhase 1
CompletedAn Open-label Safety, Tolerability and Dose-Range Finding Study of Multiple Doses of Nusinersen (ISIS 396443)
NCT01703988
BiogenPhase 1 / Phase 2
CompletedShort and Long Term Treatment With 4-AP in Ambulatory SMA Patients
NCT01645787
Columbia UniversityPhase 2 / Phase 3
TerminatedInfants With Spinal Muscular Atrophy Type I
NCT01547871
National Institute of Neurological Disorders and Stroke (NINDS)
CompletedAn Open-label Safety, Tolerability, and Dose-range Finding Study of Nusinersen (ISIS 396443) in Participants W
NCT01494701
BiogenPhase 1
CompletedFlu Vaccine Study in Neuromuscular Patients 2011
NCT01422200
Children's Hospital Medical Center, CincinnatiPhase 4
CompletedClinical Assessment of Spinal Muscular Atrophy Type II and III (SMA Europe)
NCT01611610
Institut de Myologie, FranceN/A
CompletedSpinal Muscular Atrophy and Cardiac Autonomic Function
NCT01522079
Centro Universitário Augusto MottaN/A
CompletedOptimum Insufflation Capacity in NMD
NCT01981915
Universität Duisburg-EssenN/A
CompletedClinical Trial of Exercise in Patients With Spinal Muscular Atrophy (SMA)
NCT01166022
Columbia UniversityN/A
CompletedSMN Copy Number Distribution in Mali, West Africa
NCT01059240
National Institute of Neurological Disorders and Stroke (NINDS)
CompletedMotor Development and Orthoses in Spinal Muscular Atrophy (SMA)
NCT00961103
Azienda USL Reggio Emilia - IRCCS
CompletedAerobic Training in Patients With Spinal Muscular Atrophy Type III
NCT02003937
Rigshospitalet, DenmarkN/A
CompletedEffects of Power Mobility on Young Children With Severe Motor Impairments
NCT01028833
University of OklahomaPhase 2
CompletedA Pilot Study of Biomarkers for Spinal Muscular Atrophy
NCT00756821
Carelon Research
RecruitingUK SMA Patient Registry
NCT04292574
Newcastle University
CompletedMechanisms of Cell Death in Spinal Muscular Atrophy
NCT01754441
Nemours Children's Clinic
CompletedValproic Acid in Ambulant Adults With Spinal Muscular Atrophy
NCT00481013
University of UtahPhase 2
CompletedStudy to Evaluate Sodium Phenylbutyrate in Pre-symptomatic Infants With Spinal Muscular Atrophy
NCT00528268
University of UtahPhase 1 / Phase 2
CompletedA Trial of Hydroxyurea in Spinal Muscular Atrophy
NCT00485511
Kaohsiung Medical University Chung-Ho Memorial HospitalPhase 2 / Phase 3
CompletedEvaluation of the Muscle Strength and Motor Ability in Children With Spinal Muscle Atrophy(SMA) Treated With V
NCT01033331
University of Sao Paulo General Hospital
CompletedValproic Acid and Carnitine in Patients With Spinal Muscular Atrophy
NCT00227266
University of UtahPhase 2
CompletedClinical Study of Spinal Muscular Atrophy
NCT00443066
Columbia University
UnknownEstablishing Novel Detection Techniques for Various Genetic-Related Diseases by Applying DHPLC Platform.
NCT00154960
National Taiwan University Hospital
UnknownQuantitative Analysis of SMN1 and SMN2 Gene Based on DHPLC System
NCT00155168
National Taiwan University Hospital
CompletedStudy of Safety and Dosing Effect on SMN Levels of Valproic Acid (VPA) in Patients With Spinal Muscular Atroph
NCT00374075
University of UtahPhase 1
CompletedMeasuring Levels of SMN in Blood Samples of SMA Patients
NCT00061607
National Institute of Neurological Disorders and Stroke (NINDS)
CompletedPhase II Study of Leuprolide and Testosterone for Men With Kennedy's Disease or Other Motor Neuron Disease
NCT00004771
National Center for Research Resources (NCRR)Phase 2
Approved For MarketingAveXis Managed Access Program Cohort for Access to AVXS-101
NCT03955679
United BioSource, LLC