Clinical Trials Directory

Trials / Sponsors / Great Ormond Street Hospital for Children NHS Foundation Trust

Great Ormond Street Hospital for Children NHS Foundation Trust

Academic / Other · 82 registered clinical trials11 currently recruiting.

StatusTrialPhaseStarted
Not Yet RecruitingAdvanced MRI in IVH
Intraventricular Hemorrhage Neonatal, Post-hemorrhagic Hydrocephalus
N/A2026-02-16
Not Yet RecruitingCalprotectin and Gut Disease Study
Congenital Heart Disease
2025-11-01
RecruitingThalamic Recordings in Children Undergoing SEEG
Focal Epilepsy
N/A2025-09-01
Not Yet RecruitingThe FLaME Cognitive Rehabilitation Study for Childhood Brain Tumour
Childhood Brain Tumor, Childhood Brain Tumors, Pediatric Brain Neoplasms
N/A2025-03-10
RecruitingGut Health in Children With Cancer
AML (Acute Myelogenous Leukemia, HLH, Burkitt Lymphoma/Leukemia
2025-01-30
Not Yet RecruitingSeen and Be Heard: Ensuring Fair Cancer Care for All Children
Cancer, Oncology, Haematological Malignancy
2024-09-02
RecruitingMedium to Long Term Outcomes of Selective Dorsal Rhizotomy
Cerebral Palsy
2024-06-25
RecruitingMicro-dosing Indocyanine Green (ICG) in Children
Perfusion, Fluorescence Imaging, Gastrointestinal Tract Disorders
N/A2024-06-01
UnknownFirst-in-human Experience Using Novel Ultraflexible Low-impedance Electrode Arrays: an IDEAL Stage 1 Study
Epilepsy, Focal Cortical Dysplasia
N/A2024-02-01
UnknownSMILES: Study of Montelukast in Sickle Cell Disease
Anemia, Sickle Cell, Sleep-Disordered Breathing
Phase 2 / Phase 32023-10-16
Unknown90Y-labelled Anti-CD66 ab in Childhood High Risk Leukaemia
Leukemia
Phase 22023-09-29
Active Not RecruitingBase Edited CAR T Cells Against AML: Deep Conditioning Ahead of Allogeneic Stem Cell Transplantation
Relapsed Acute Myeloid Leukaemia
Phase 12023-07-21
UnknownImproving Phosphate Control in Children With CKD
Chronic Kidney Diseases, Hyperphosphatemia, Pediatric Kidney Disease
2023-06-20
RecruitingLentiviral Gene Therapy for p47 AR-CGD
P47-Phox, Deficiency of
Phase 1 / Phase 22023-03-20
UnknownOptical Coherence Tomography Angiography (OCTA) in Children's Cardiac Surgery
Congenital Heart Disease, Children, Only
N/A2022-10-01
UnknownHow Does Task Loading in PICU Impact on Clinician Situational Awareness and Awareness of the Passage of Time?
Clinician Perception, Clinician Attention
N/A2022-09-01
UnknownBase Edited CAR7 T Cells to Treat T Cell Malignancies (TvT CAR7)
Relapsed/Refractory T-cell Acute Lymphoid Leukaemia
Phase 12022-04-19
CompletedBrain Involvement in Dystrophinopathies Part 2
Duchenne Muscular Dystrophy, Becker Muscular Dystrophy
2021-10-11
UnknownBabies in Glasses; a Feasibility Study.
Cerebral Visual Impairment, Refractive and Accommodative Disorders, Hypoxic-Ischemic Encephalopathy
N/A2021-09-09
UnknownGene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services
Epilepsy
2021-09-01
RecruitingInfant and Child European Cryoablation Project ICECaP
Therapy, Soft Tissue Lesion, Cryoablation
2021-06-24
CompletedBrain Involvement in Dystrophinopathies Part 1
Duchenne Muscular Dystrophy, Becker Muscular Dystrophy
2021-03-30
UnknownComparison of Pre- vs Post-dilution Haemodiafiltration in Children
Haemodiafiltration
2021-02-01
UnknownSwallowing, Feeding and Eating in Children Born With Oesophageal Atresia/Trache-oesophageal Fistula (OA/TOF)
Esophageal Atresia With Tracheoesophageal Fistula
2020-12-15
UnknownMethods of Providing Information Prior to an Alveolar Bone Graft
Cleft Lip and Palate
N/A2020-12-09
UnknownNatural History Study of Pyruvate Dehydrogenase Deficiency
Pyruvate Dehydrogenase Complex Deficiency, Pyruvate Dehydrogenase E1 Alpha Deficiency, Pyruvate Dehydrogenase E1-Beta Deficiency
2020-11-01
CompletedTT52CAR19 Therapy for B-cell Acute Lymphoblastic Leukaemia (B-ALL)
B Acute Lymphoblastic Leukemia
Phase 12020-08-12
CompletedIdentifying and Understanding Risk Factors for Instability and Adverse Events Associated With Chest Physiother
Respiratory Failure
2020-07-29
UnknownMELD as an Adjunct for SEEG Trajectories
Epilepsy, Epilepsy, Focal, Epilepsy, Refractory
N/A2020-07-01
CompletedCOVID-19 Staff Testing of Antibody Responses Study (Co-Stars)
SARS-CoV-2 Infection
2020-04-27
UnknownRole of Immune and Inflammatory Response in Recipients of Allogeneic Haematopoietic Stem Cell Transplantation
COVID19
2020-04-15
Active Not RecruitingEvaluation of Aid to Diagnosis for Congenital Dysplasia of the Hip in General Practice
Developmental Dysplasia of the Hip
N/A2020-03-06
CompletedNewborn Screening for Spinal Muscular Atrophy (SMA) - a Proof of Principle Study Using Anonymised Blood Spots.
Spinal Muscular Atrophy
2019-11-11
CompletedIntermittent Dosing Of Selumetinib In Childhood NF1 Associated Tumours
Neurofibromatosis Type 1, Plexiform Neurofibroma, Optic Nerve Glioma
Phase 1 / Phase 22019-09-26
UnknownNovel Network Analysis of Intracranial Stereoelectroencephalography
Epilepsy in Children, Focal Epilepsy, Epilepsy Intractable
N/A2019-06-16
Completed'Fitness To Fly' Tests In Children With Type II Respiratory Failure
Neuromuscular Diseases, Central Hypoventilation
N/A2019-02-01
CompletedDifferences in Access to Emergency Paediatric Intensive Care and Care During Transport
Access and Transport to Paediatric Intensive Care
2019-01-01
RecruitingLentiviral Gene Therapy for X-linked Severe Combined Immunodeficiency
Severe Combined Immunodeficiency, X-Linked
Phase 12018-12-21
CompletedElectroretinogram in Autistic Spectrum Disorders
Autism Spectrum Disorder
2018-09-03
CompletedMonitor Faecal Calprotectin Concentration in Infants With Heart Defects
Calprotectin, Cyanotic Heart Disease
2018-05-01
CompletedAdvanced MRI for Posterior Fossa Tumours
Cerebellar Mutism, Posterior Fossa Syndrome
2018-04-09
SuspendedNIRS to Evaluate Haemodynamic Reserve in Paediatric Moyamoya
Moyamoya
N/A2018-02-14
CompletedWhat is the Feasibility of the ISTEP Exercise Test in Boys With Haemophilia
Hemophilia
N/A2018-01-25
CompletedEfficacy and Safety of the Cryopreserved Formulation of OTL-101 in Subjects With ADA-SCID
Severe Combined Immunodeficiency Due to ADA Deficiency
Phase 1 / Phase 22018-01-03
CompletedConservative Versus Liberal Oxygenation Targets in Critically Ill Children
Critical Care, Hypoxia, Pediatric ALL
N/A2017-03-04
UnknownCalcium Balance Studies in Children With CKD and on Dialysis
Chronic Kidney Disease Mineral and Bone Disorder
2017-02-01
TerminatedMeasuring the Metabolic Cost of Fever
Child, Critical Illness, Fever
2016-11-01
CompletedKidney Transplant Monitoring Using Near Infra-red Spectroscopy
Kidney Transplant; Complications
2016-11-01
CompletedYttrium-90 Anti CD66 Monoclonal Antibody in Childhood Relapsed/Refractory Leukaemia
Acute Myeloblastic Leukemia, Acute Lymphoblastic Leukemia, Juvenile Myelomonocytic Leukemia
Phase 12016-05-01
UnknownThe Management of Systemic-Pulmonary Collateral Blood Flow in Cyanotic Children During Cardiopulmonary Bypass
Heart Defects, Congenital
N/A2016-03-01
CompletedFIRST-line Support for Assistance in Breathing in Children (FIRST-ABC) Feasibility Study
Hypoxia, Respiratory Acidosis, Moderate/Severe Respiratory Distress
Phase 2 / Phase 32015-11-01
UnknownThe Use of Home Oral Glucose Tolerance Test Kit in Screening Cystic Fibrosis Related Diabetes
Cystic Fibrosis Related Diabetes, Cystic Fibrosis
N/A2015-10-01
CompletedQuality of Postoperative Recovery in Children and Young People
Quality of Recovery
2015-06-01
CompletedGait Analysis in Idiopathic Clubfoot Patients Treated by the Ponseti Method
Congenital Talipes Equino Varus
2015-03-01
CompletedVascular Dysfunction in Paediatric IBD
Inflammatory Bowel Disease, Crohn Disease, Ulcerative Colitis
2014-09-01
CompletedThe Eat Right Emirates Healthy Lifestyle Study
Childhood Obesity, Dietary Habits
N/A2014-09-01
CompletedPrevalence of Autistic Spectrum Disorder (ASD) in Children With Haemophilia
Haemophilia, Autism Spectrum Disorder, Social Communication Disorder
2014-09-01
CompletedCharacteristics and Outcomes of Childhood Moyamoya in the UK
Moyamoya
2014-08-01
CompletedCorrelation of Nasopharyngeal (NP) and Lower Oesophageal (LO) Temperatures in Ventilated Children
Child
N/A2014-06-25
UnknownGene Therapy for Netherton Syndrome
Netherton Syndrome
Phase 12014-04-01
CompletedBiomarkers of Acute Serious Illness in Children
Critical Illness, Infection, Mixed, Children, Only
2014-04-01
CompletedTreosulfan Pharmacokinetics in Children Undergoing Allogeneic HSCT
Allogeneic Haematopoietic Stem Cell Transplantation
2014-03-01
UnknownHaemodiafiltration vs Conventional Haemodialysis in Children
Children, Haemodialysis, Haemodiafiltration
2014-02-01
WithdrawnPathophysiology of Dilated Cardiomyopathy
Dilated Cardiomyopathy
2014-01-01
UnknownImproving Standards of Care and Translational Research in Spinal Muscular Atrophy (SMA)
Spinal Muscular Atrophy
2013-12-17
WithdrawnInvestigating Prevalence of Disordered Eating in Children With GI Disorders
Disordered Eating
N/A2013-07-01
CompletedBlood Propofol Concentrations in Children During Spinal Surgery
Spine Deformities, Idiopathic Scoliosis, Neuromuscular Dystrophy
Phase 42013-01-01
CompletedLentiviral (LV) Gene Therapy for Adenosine Deaminase (ADA) Deficiency
Adenosine Deaminase Deficiency, Severe Combined Immunodeficiencies (SCID)
Phase 1 / Phase 22012-11-15
CompletedMeasuring Normal and Impaired Walking in Children Using the GAITRite Walkway
Typically Developing Children, Talipes Equino Varus, Paediatric Orthopaedic
N/A2012-05-01
CompletedINSPIRE-CF: an Alternative Physiotherapy Model for Children With Cystic Fibrosis
Cystic Fibrosis
N/A2012-05-01
UnknownOutcome Study of Endoscopically Inserted Gastrostomy (PEG)Versus Radiologically-guided Insertion of Gastrostom
Two Interventions (PEG and RIG) Compared Against Each Other
N/A2011-12-01
WithdrawnLentiviral Gene Therapy for X-Linked Chronic Granulomatous Disease (X-CGD)
Granulomatous Disease, Chronic, X-linked, Variant
Phase 1 / Phase 22011-11-01
CompletedHow Easy is it to Identify the Cricothyroid Membrane in Children? Can Ultrasound Imagine be Used to Aid Identi
Cricothyroidotomy
N/A2011-08-01
CompletedNEMO1:NEonatal Seizure Using Medication Off-patent
Neonatal Seizures
Phase 1 / Phase 22011-08-01
CompletedThe iStep Study: Development and Validation of an Incremental Exercise Step Test for Children With Cystic Fibr
Cystic Fibrosis
N/A2011-07-01
UnknownGene Therapy for X-linked Severe Combined Immunodeficiency (SCID-X1)
X-linked Severe Combined Immunodeficiency
N/A2011-04-01
TerminatedSuicide Gene Therapy Trial
Haploidentical Stem Cell Transplantation
Phase 1 / Phase 22011-01-01
TerminatedTherapeutic Controlled Hypothermia in the Treatment of Neonates With Severe Necrotizing Enterocolitis
Necrotizing Enterocolitis
N/A2010-08-02
CompletedOpen or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood Gases
Esophageal Atresia With Tracheo-esophageal Fistula, Congenital Diaphragmatic Hernia
N/A2009-08-01
CompletedA Trial of Autologous Bone Marrow Derived Stem Cells in Paediatric Heart Failure
Dilated Cardiomyopathy
N/A2008-05-01
CompletedSafety and Efficacy of Emergency On-call Respiratory Physiotherapy Services in the Paediatric Intensive Care U
Pediatrics, Critical Care, Respiration, Artificial
N/A2006-07-01
CompletedGene Therapy ADA Deficiency
Adenosine Deaminase Deficiency
Phase 1 / Phase 22003-10-01