NCT03824223

'Fitness To Fly' Tests In Children With Type II Respiratory Failure

'Fitness To Fly' Testing In Children With Neuromuscular Weakness Or Central Hypoventilation: A Feasibility Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust · Academic / Other
• Sex: All
• Age: 0 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

The conventional hypoxic challenge test might not predict 'fitness-to-fly' equally well in all patients. Patients at risk of hypercapnia with supplemental oxygen are not well studied. Th investigators will study children who have either neuromuscular weakness or central hypoventilation and who require nocturnal or intermittent daytime ventilator support. The study also aims to assess feasibility of a randomised controlled trial (RCT) comparing the standard hypoxic standard test to a modified test designed to better suit children with type two respiratory failure.

Detailed description

This study will assess feasibility of pulse oximetry (SpO2), end tidal carbon dioxide (ETCO2) and transcutaneous carbon dioxide partial pressure (TcCO2) measurement during a modified Hypoxic challenge test (HCT) in 12 children with neuromuscular weakness and 12 with central hypoventilation.

Conditions

• Neuromuscular Diseases
• Central Hypoventilation

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Hypoxic challenge test	Physiological response to 15% ambient oxygen monitored.

Timeline

• Start date: 2019-02-01
• Primary completion: 2021-08-31
• Completion: 2021-08-31
• First posted: 2019-01-31
• Last updated: 2021-12-08

Locations

1 site across 1 country: United Kingdom