NCT05160454

NIRS to Evaluate Haemodynamic Reserve in Paediatric Moyamoya

• Status: Suspended
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust · Academic / Other
• Sex: All
• Age: 6 Years – 18 Years
• Healthy volunteers: Accepted

Summary

Near infrared spectroscpy is a validated method of evaluating cerebral blood flow. The aim in this pilot study to explore its use in children with moyamoya disease.

Detailed description

Moyamoya disease is a cerebrovascular condition in which there is chronic brain hypoperfusion. As surgery can possibly augment brain blood flow, a method for evalutaing cerebrovascualr reserve would be helpful in selecting patients for intervention. Near infrared spectroscopy (NIRS) is a validated non-invasive method of evaluating cerebral blood flow. We aim to investigate the feasibility and tolerability of using NIRS haemodynamic reserve in children with moyamoya and controls by evaluating cerebral blood flow in the baseline state and after breath-holding. Feasibility will be assessed by how many successful studies are carried out. Tolerability will be assessed by asking children some simple questions about their experience.

Conditions

• Moyamoya

Interventions

Type	Name	Description
DEVICE	near infrared spectroscopy	evaluate cerebral blood flow with and without breatholding

Timeline

• Start date: 2018-02-14
• Primary completion: 2022-06-30
• Completion: 2022-06-30
• First posted: 2021-12-16
• Last updated: 2021-12-16

Locations

1 site across 1 country: United Kingdom