| Not Yet Recruiting | The Use of Remimazolam Versus Dexmedetomidine for Patients Receiving Drug-Induced Sleep Endoscopy NCT07459322 | Fu Jen Catholic University Hospital | N/A |
| Not Yet Recruiting | EEG Signal Correlates During Anesthesia and Sedation in Adults and Children NCT07460414 | Assistance Publique - Hôpitaux de Paris | — |
| Recruiting | Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration NCT07269808 | Massachusetts General Hospital | Phase 3 |
| Completed | Effect of IV Lidocaine on Duodenal Peristalsis and Sedation in ERCP NCT07333859 | Ankara City Hospital Bilkent | Phase 4 |
| Not Yet Recruiting | Safety Exploration and Evaluation of Dexmedetomidine Hydrochloride Nasal Spray for Pre-anesthesia Sedation in NCT07298525 | Sichuan Provincial People's Hospital | Phase 4 |
| Not Yet Recruiting | End-of-life Care in Mechanically Ventilated Patients: Impact of a Comprehensive Palliative Care Protocol in th NCT07368010 | Nantes University Hospital | N/A |
| Not Yet Recruiting | Efficacy and Safety of Anricofen Combined With Ciprofol for Deep Sedation in Elderly Patients Undergoing ERCP NCT07376577 | The First Affiliated Hospital of Xinxiang Medical College | N/A |
| Not Yet Recruiting | The Effect of Reversal of Remimazolam Sedation With Flumazenil on Cognitive Function in Patients Undergoing Hi NCT07277881 | Medical University of Gdansk | Phase 4 |
| Not Yet Recruiting | Children of Age 2-6years Undergoing Elective Surgery Will be Divided Into Two Groups Randomly. This Study Aims NCT07180095 | Liaquat National Hospital & Medical College | Phase 1 / Phase 2 |
| Recruiting | Inhaled Sedation in Critically Ill Patients NCT07000526 | Instituto de Investigación Hospital Universitario La Paz | Phase 4 |
| Active Not Recruiting | The Effect of Preoperative Dexmedetomidine and Tramadol on Sedation, Pain and Haemodynamics in Haemorrhoids Pa NCT06860100 | Yuzuncu Yil University | — |
| Not Yet Recruiting | Bispectral Monitoring on Mechanically Ventilated Patients NCT07219069 | The University of Texas Health Science Center, Houston | N/A |
| Not Yet Recruiting | Preparing Kids for MRI Using VR NCT07203716 | Haseki Training and Research Hospital | N/A |
| Recruiting | Light and Anesthesia NCT07517484 | Peking University People's Hospital | N/A |
| Withdrawn | The Dreamy Jet Study NCT06919198 | University of Wisconsin, Madison | Phase 1 |
| Not Yet Recruiting | Study Comparing Atomizerd Midazolam & Fentanyl and Dexmedomidine for Procedural Sedation in Adult and Pediatri NCT07166666 | Oman Medical Speciality Board | N/A |
| Recruiting | Oral vs IV Sedation for Cataract Surgery in Older Adults NCT07154147 | University of California, San Francisco | Phase 4 |
| Completed | Comparison of Intranasal Dexmedetomidine and Short Video Viewing in the Preoperative Anxiety NCT07077200 | Samsun University | — |
| Enrolling By Invitation | a Prospective Randomised Study Evaluating the Efficacy of Intranasal Midazolam and Dexmedetomidine as a Sedati NCT07502651 | Postgraduate Institute of Dental Sciences Rohtak | EARLY_Phase 1 |
| Completed | The Effect of Music on the Sedation Quality Among Children in the Emergency Department. NCT06876194 | Tehran University of Medical Sciences | Phase 3 |
| Completed | EEG-Guided Sedation in ERCP Procedures NCT06866886 | Ankara City Hospital Bilkent | — |
| Active Not Recruiting | Evaluation of Ketamine/Midazolam Sedation vs. Fentanyl/Midazolam Sedation for Image-Guided Percutaneous Proced NCT07040163 | CAMC Health System | EARLY_Phase 1 |
| Recruiting | Remimazolam Besylate in Sedation of Postcardioperative Patients NCT06716840 | First Affiliated Hospital of Zhejiang University | N/A |
| Recruiting | A Comparative Study of Eleveld and Schnider Pharmacokinetic Models for Target-Controlled Infusion of Propofol NCT07239687 | Hacettepe University | — |
| Recruiting | Sedation Efficacy and Safety of Remazolam Besylate in Ventilated Surgical Critically Ill Patients NCT06575530 | Beijing Shijitan Hospital, Capital Medical University | Phase 4 |
| Completed | Effects of Different Sedation Techniques on Early Cognitive Recovery After Ambulatory Gynecologic Surgery NCT07267377 | Sait Fatih Öner | N/A |
| Completed | Estimation of Analgetic Effect and Cooperability of Pediatric Patients During Application of Gass Mixture of O NCT07159425 | Mother and Child Health Institute of Serbia Dr Vukan Cupic | — |
| Recruiting | Sevoflurane Sedation as an Alternative for Awake Fiberoptic Intubation in Difficult Airway Patients NCT06601036 | Tanta University | N/A |
| Recruiting | Sedation in ICU Patients With Mechanical Ventilation NCT06538883 | Zhongda Hospital | N/A |
| Recruiting | Additive Effects of Clonidine Used in Propofol Sedation in Colonoscopy NCT06507410 | Tanta University | N/A |
| Recruiting | Evaluation of the Impact of Virtual Reality on Sedation Use in Patients Undergoing Regional Anesthesia for Sch NCT07013695 | Centre Hospitalier Eure-Seine | N/A |
| Recruiting | Comparison of High Flow Nasal Oxygen and Nasal Cannula in Burn Patients Under Sedation NCT06756906 | Ankara City Hospital Bilkent | — |
| Recruiting | Neurosteer Bedside Monitoring System NCT06718764 | Icahn School of Medicine at Mount Sinai | N/A |
| Recruiting | Frequency of Adverse Events in Pediatric Patients Receiving Sedation for Magnetic Resonance Imaging NCT06467045 | Sisli Hamidiye Etfal Training and Research Hospital | — |
| Completed | Propofol-ketamine or Propofol-fentanyl for Procedural Sedation in the Short-term Gynecological Case NCT06412861 | Ondokuz Mayıs University | N/A |
| Recruiting | Nebulized Dexmedetomidine Combined With Ketamine Versus Nebulized Dexmedetomidine for Cleft Palate NCT05821972 | Assiut University | Phase 4 |
| Completed | Evaluation of Sedation Depth and Reliability With Integrated Pulmonary Index (IPI) Follow-up in Pediatric Radi NCT06343896 | Ankara City Hospital Bilkent | — |
| Completed | Effect of Esketamine on 95% Induction Dose of Remimazolam NCT06303037 | Second Affiliated Hospital of Wenzhou Medical University | Phase 4 |
| Completed | Nebulized Dexmedetomidine as a Premedication for Gastrointestinal Endoscopy in Pediatric Patients NCT06218797 | Ondokuz Mayıs University | N/A |
| Completed | Nerve Block Vs Sedation Infusion for Awake Fiberoptic Intubation. NCT06651905 | Cairo University | N/A |
| Unknown | the 95% Effective Dose of Ciprofol for Adjunctive Sedation Undergoing Knee Arthroplasty in Elderly People NCT06293144 | Second Hospital of Shanxi Medical University | EARLY_Phase 1 |
| Completed | The Effect of Sedation on Rebound Pain in Knee Arthroplasty NCT06555458 | Ankara City Hospital Bilkent | N/A |
| Completed | A Study to Learn About the Study Medicine - Precedex in Children From Japan. NCT06085573 | Pfizer | — |
| Completed | Musical Intervention and Physiological Stress and Inflammatory Biomarkers in Mechanically Ventilated ICU Patie NCT06120660 | University of Oviedo | N/A |
| Completed | The ED95 of Single Intravenous Bolus Remimazolam Besylate in Pediatric Patients During General Anesthesia Indu NCT06061159 | Second Affiliated Hospital of Wenzhou Medical University | Phase 4 |
| Completed | Comparison of Guiding Sedation Level by Respiratory Effort Versus Usual Care in Mechanically Ventilated Patien NCT06242236 | Ramathibodi Hospital | N/A |
| Completed | Cognitive Function in Geriatric Colonoscopy Patients NCT07384169 | Ankara City Hospital Bilkent | — |
| Completed | Median Effective Dose of Ciprofol-Assisted Sedation for Elderly Patients Undergoing Knee Arthroplasty NCT06293131 | Second Hospital of Shanxi Medical University | EARLY_Phase 1 |
| Completed | Dexmedetomidine Versus General Anesthesia on the Diagnosis of Endobronchial US-Guided Transbronchial Needle As NCT05781035 | Kafrelsheikh University | N/A |
| Completed | High Flow Nasal Oxygen Versus Standard Nasal Oxygen in Endoscopic Retrograde Cholangiopancreatography Under Se NCT06689033 | Ankara City Hospital Bilkent | — |
| Completed | Dexmedetomidine-Propofol Versus Ketamine-Propofol for Sedation of CT Guided Bone Biopsy NCT05752903 | National Cancer Institute, Egypt | Phase 4 |
| Completed | Esketamine Combined With Dexmedetomidine Sedation in Head MRI Examination of Children With Autism Spectrum Dis NCT06633315 | Maternal and Child Health Hospital of Hubei Province | Phase 2 |
| Unknown | Inhalational Sedation and Mechanical Power NCT05559970 | Mahidol University | N/A |
| Completed | Ketamine Versus Propofol as ICU Sedation NCT06243822 | Menoufia University | Phase 4 |
| Unknown | Comparing Ciprofol and Propofol for Sedation in Hypotensive ICU Patients: a Single Center Prospective Cohort S NCT05971121 | Nanfang Hospital, Southern Medical University | — |
| Unknown | Comparison of Oral Chloral Hydrate and Combination of Intranasal Dexmedetomidine and Ketamine for Rescue After NCT04822064 | Seoul National University Hospital | N/A |
| Completed | Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol f NCT05327296 | Sedana Medical | Phase 3 |
| Completed | Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol f NCT05312385 | Sedana Medical | Phase 3 |
| Active Not Recruiting | A Pooled Analysis of Long-Term Outcomes After Inhaled Isoflurane Via the Sedaconda ACD-S Compared to Intraveno NCT06809218 | Sedana Medical | Phase 3 |
| Completed | Sedation With Remimazolam During Spinal Anesthesia NCT05305248 | Gangnam Severance Hospital | N/A |
| Completed | Gastro-laryngeal Tube During Transesophageal Echocardiography NCT05272306 | Bezmialem Vakif University | N/A |
| Unknown | RemImazolam Besylate for ICU-sedation in Patients With Mechanical Ventilation After Oral and Maxillofacial Sur NCT05606315 | Nanfang Hospital, Southern Medical University | Phase 4 |
| Unknown | Endoscopic Hemostatic and Sedative Treatment of Esophageal and Gastric Variceal Bleeding NCT05554965 | Renmin Hospital of Wuhan University | Phase 4 |
| Unknown | Lidocaine Infusion for Propofol Dose Reduction in ERCP Procedure NCT05274984 | Iuliu Hatieganu University of Medicine and Pharmacy | Phase 1 |
| Completed | Dexmedetomidine Versus Ketofol for Moderate Sedation in Endoscopic Retrograde Cholangiopancreatography NCT06212401 | Sindh Institute of Urology and Transplantation | Phase 4 |
| Completed | Comparison of Oral Chloral Hydrate and Combination of Intranasal Dexmedetomidine and Ketamine for Procedural S NCT04820205 | Seoul National University Hospital | N/A |
| Completed | Adjuvant Continuous Infusion of Nefopam Versus Standard of Care in Mechanically Ventilated Critically Ill Pati NCT05071352 | Cairo University | Phase 3 |
| Suspended | Risk Prediction of Dexmedetomidine-associated Hemodynamic Instability NCT03285087 | Assiut University | Phase 2 / Phase 3 |
| Unknown | A Randomized Single-blind Clinical Trial of the Efficacy and Safety of Remimazolam in Painless Bronchoscopy NCT04919174 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 4 |
| Unknown | Effects of NIV and CPAP on Ventilation Distribution, Measured by EIT, During Deep Sedation in Paediatric Patie NCT05495477 | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | N/A |
| Unknown | Remimazolam for Sedation in ICU Patients Undergoing Mechanical Ventilation NCT04815265 | Tianjin Nankai Hospital | Phase 4 |
| Completed | Dexmedetomidine Versus Propofol for Sedation During Awake Endotracheal Intubation NCT04753515 | Sixth Affiliated Hospital, Sun Yat-sen University | Phase 4 |
| Completed | Effect & Safety of Inhaled Isoflurane vs IV Midazolam for Sedation in Mechanically Ventilated Children 3-17 Ye NCT04684238 | Sedana Medical | Phase 3 |
| Completed | Propranolol as an Anxiolytic to Reduce the Use of Sedatives From Critically-ill Adults Receiving Mechanical Ve NCT04467086 | Ottawa Hospital Research Institute | Phase 3 |
| Unknown | Pre-emptive Pregabalin on Attenuating Maternal Anxiety And Stress Response To Intubation During Caesarean Sect NCT04622202 | Zagazig University | Phase 1 / Phase 2 |
| Unknown | End-Tidal Carbon Dioxide Monitoring Device for Sedation During Endoscopic Ultrasonography NCT04549623 | Changhai Hospital | N/A |
| Unknown | The Effect of Music on Delirium, Pain, Need of Sedation, Anxiety and Vital Parameters NCT05082623 | Ege University | N/A |
| Unknown | Sedation and Ventilator Weaning Protocol in PICU NCT04788589 | Indonesia University | N/A |
| Unknown | Intravenous Infusion of Lidocaine in Colonoscopy NCT04439786 | Shandong University | Phase 4 |
| Unknown | Intravenous Infusion of Lidocaine in Gastroscopy NCT04439773 | Shandong University | Phase 4 |
| Completed | Inhaled Sedation in COVID-19-related Acute Respiratory Distress Syndrome (ISCA): an International Research Dat NCT04383730 | University Hospital, Clermont-Ferrand | — |
| Completed | A Clinical Study of Remimazolam Tosilate in Patients Undergoing Bronchoscopy NCT04400201 | Jiangsu HengRui Medicine Co., Ltd. | Phase 3 |
| Withdrawn | A Study Evaluating the Mass Balance of Micro-dose[14C]HSK3486 Emulsion Injection in Healthy Adults NCT03751969 | Sichuan Haisco Pharmaceutical Group Co., Ltd | Phase 1 |
| Withdrawn | LEGO MRI: Decreasing the Need for Sedation, and Improving Patient Anxiety. NCT04172909 | Montefiore Medical Center | N/A |
| Completed | Controlled Sedoanalgesia in External DCR Surgery NCT05397301 | Turkish Society of Anesthesiology and Reanimation | N/A |
| Completed | Risk Factors for Prolonged Invasive Mechanical Ventilation in COVID-19 Acute Respiratory Distress Syndrome NCT04411459 | Azienda Usl di Bologna | — |
| Unknown | Dexmedetomidine Sedation in Orthopedic Surgery NCT04149626 | Asklepieion Voulas General Hospital | Phase 2 |
| Completed | A Study Evaluating Drug-Drug Interaction (DDI) Between HSK3486 Injectable Emulsion and Voriconazole Tablets NCT04145583 | Sichuan Haisco Pharmaceutical Group Co., Ltd | Phase 1 |
| Completed | A Study Evaluating the Efficacy and Safety of HSK3486 for Sedation NCT04147416 | Sichuan Haisco Pharmaceutical Group Co., Ltd | Phase 2 |
| Unknown | The Use of Ketamine and Dexmedetomidine in Intensive Care Sedation NCT04096768 | Lebanese American University Medical Center | Phase 3 |
| Completed | Analgosedative adjuncT keTAmine Infusion iN Mechanically vENTilated ICU Patients NCT04075006 | King Faisal Specialist Hospital & Research Center | Phase 3 |
| Completed | Precedex Special Investigation (in Pediatric Patients) NCT04040439 | Pfizer | — |
| Unknown | Incidence OIRD Medical and Trauma Patients NCT03948880 | Community Health System | — |
| Completed | The Deep Sedation for Ablation Study NCT03844841 | Insel Gruppe AG, University Hospital Bern | Phase 4 |
| Unknown | Sedation Strategies for Therapeutic Bronchoscopy 2 NCT03983915 | Changhai Hospital | N/A |
| Unknown | Sedation Strategies for Diagnostic Bronchoscopy 2 NCT03983889 | Changhai Hospital | N/A |
| Completed | Comparison of Two Sedation Versus Placebo Techniques During Cataract Surgery Under Local Anesthesia NCT04149340 | University of Liege | N/A |
| Unknown | Intravenous Infusion of Lidocaine in ERCP NCT03996577 | Shandong University | Phase 4 |
| Completed | High-Flow Nasal Oxygenation Versus Standard Oxygenation in Gastrointestinal Endoscopy With Sedation. NCT03829293 | Centre Hospitalier Régional d'Orléans | N/A |
| Completed | A Study Evaluating the Safety and Pharmacokinetics/Pharmacodynamics of HSK3486 NCT03745625 | Sichuan Haisco Pharmaceutical Group Co., Ltd | Phase 1 |
| Completed | A Study Evaluating the Mass Balance of [14C]HSK3486 Emulsion Injection in Healthy Adults. NCT03751956 | Sichuan Haisco Pharmaceutical Group Co., Ltd | Phase 1 |
| Terminated | Automated Postoperative Sedation After Cardiac Surgery NCT03517735 | CMC Ambroise Paré | N/A |
| Completed | A Study Evaluating Drug-Drug Interaction (DDI) Between HSK3486 Injectable Emulsion and Rifampin Capsules NCT03758469 | Sichuan Haisco Pharmaceutical Group Co., Ltd | Phase 1 |
| Terminated | Intranasal Dexmedetomidine for Procedural Pain Management in Elderly Adults in Palliative Care NCT03151863 | Walid HABRE | Phase 3 |
| Completed | Propofol vs. Midazolam With Propofol for Sedative Endoscopy in Patients With Previous Paradoxical Reaction to NCT04072328 | DongGuk University | Phase 2 |
| Completed | Intranasal Dexmedetomidine Sedation in Children for Non-painful Procedures NCT03220880 | Columbia University | — |
| Withdrawn | Incidence of Opioid-Induced Respiratory Depression in Medical and Trauma Patients NCT03647696 | Poudre Valley Health System | — |
| Completed | Study of Remimazolam Tosilate in Patients Undergoing Colonoscopy NCT03779061 | Jiangsu HengRui Medicine Co., Ltd. | Phase 3 |
| Completed | Assessment of Analgesia, Sedation, Physical Restraints and Delirium in Spanish Intensive Care Units NCT03773874 | Hospital Universitario Getafe | — |
| Completed | Sedation MRI - Propofol Versus Propofol-Ketamin in Children NCT01519154 | Achim Schmitz | Phase 3 |
| Completed | Sedation Of Adult Patients Undergoing Gastrointestinal Endoscopy: A Network Meta-analysis NCT03632330 | Pfizer | — |
| Terminated | Sedation Strategies for Therapeutic Bronchoscopy NCT03406546 | Changhai Hospital | N/A |
| Terminated | Sedation Strategies for Diagnostic Bronchoscopy NCT03406533 | Changhai Hospital | N/A |
| Completed | Effect of Midazolam and Dexmedetomidine on Heart Function - A Randomized MRI-based Study. NCT04529187 | Masaryk Hospital Krajská zdravotní a.s. | Phase 4 |
| Completed | Safety and Efficacy of Sufentanil Combined With Midazolam in Bronchoscopy Under Conscious Sedation: Retrospect NCT03890094 | Guangzhou Institute of Respiratory Disease | — |
| Terminated | Deep Brain Stimulation (DBS) Sedation NCT03283150 | University of Wisconsin, Madison | Phase 4 |
| Completed | Comparison of Intravenous V/S Nasal Atomizer Delivery of Midazolam for Conscious Sedation for No-scalpel Vasec NCT06449365 | University of Tennessee Graduate School of Medicine | Phase 4 |
| Completed | Oral Versus Intravenous Sedation for Ocular Procedures NCT03246724 | Boston Medical Center | Phase 4 |
| Suspended | Cerebral Vascular Effects of Dexmedetomidine Versus Propofol Sedation in Intubated Mechanically Ventilated ICU NCT03285165 | Assiut University | Phase 2 / Phase 3 |
| Completed | Study of Remimazolam Tosilate in Patients Undergoing Diagnostic Upper GI Endoscopy NCT03425474 | Jiangsu HengRui Medicine Co., Ltd. | Phase 3 |
| Unknown | Sedation During Pediatric Diagnostic Gastrointestinal Endoscopy Gastrointestinal Endoscopy NCT03235609 | Assiut University | N/A |
| Completed | Sedation Practices and Preferences of Turkish Intensive Care Physicians: National Survey NCT03488069 | Istanbul University | — |
| Completed | Implementation of an Analgesia-sedation Algorithm in the Pediatric ICU to Reduce Benzodiazepine Use NCT04263662 | Boston Children's Hospital | — |
| Unknown | Safety, Pharmacokinetics and Pharmacodynamics of Intranasal Dexmedetomidine in Healthy Subjects NCT03293277 | Jiangsu HengRui Medicine Co., Ltd. | Phase 1 |
| Completed | Sedation of Advanced Endoscopic Procedure NCT03172078 | National Taiwan University Hospital | N/A |
| Completed | Pharmacokinetics and Pharmacodynamics of Oral Transmucosal Dexmedetomidine. NCT03120247 | Assiut University | Phase 2 / Phase 3 |
| Recruiting | The Effects of Different Anesthetics on Functional Connectivity NCT03343873 | Beijing Tiantan Hospital | N/A |
| Completed | Dexmedetomidine Versus Propofol in Conjunction With Regional Block for Shoulder Arthroscopy NCT03775876 | Saint-Joseph University | Phase 4 |
| Completed | Sedation Using Virtual Reality During Surgery Under Spinal Anesthesia NCT03055663 | Seoul National University Hospital | N/A |
| Completed | Dexmedetomidine vs Midazolam on Resting Energy Expenditure in Critically Ill Patients NCT03030911 | Cairo University | Phase 4 |
| Unknown | The Use of Capnography and Integrated Pulmonary Index in the Electrophysiology Laboratory NCT03025490 | Hadassah Medical Organization | N/A |
| Completed | Safety And Efficacy Of Dexmedetomidine Sedation In Intubated Mechanically Ventilated Infants With Respiratory NCT02996058 | Assiut University | Phase 2 / Phase 3 |
| Completed | A Study Evaluating Safety, Pharmacodynamics and Pharmacokinetics of HSK3486 and Etomidate for Induction of Ane NCT04054063 | Sichuan Haisco Pharmaceutical Group Co., Ltd | Phase 1 |
| Completed | A Study of Remimazolam Tosilate in Patients Undergoing Diagnostic Upper GI Endoscopy NCT03003884 | Jiangsu HengRui Medicine Co., Ltd. | Phase 2 |
| Completed | Doxapram as an Additive to Propofol Sedation in Sedation for ERCP NCT02171910 | Helsinki University Central Hospital | Phase 4 |
| Unknown | Bispectral Index(BIS) on Depth of Sedation With Dexmedetomidine, Propofol and Midazolam During Spinal Anesthes NCT03399019 | Hallym University Medical Center | N/A |
| Completed | Patient-controlled Sedation With Propofol During Cataract Surgery Under Topical Anesthesia NCT02771912 | Fondation Ophtalmologique Adolphe de Rothschild | Phase 4 |
| Completed | A Study Evaluating Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of Single IV Dose of HSK3486 In NCT03773835 | Sichuan Haisco Pharmaceutical Group Co., Ltd | Phase 1 |
| Unknown | The Effect of Continuous Femoral Nerve Block With Modulation of Depth of Anesthesia on Prognosis of Patients R NCT02576015 | Min Su | N/A |
| Recruiting | The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes NCT07022951 | Massachusetts General Hospital | — |
| Completed | Risk Factors of Delirium in Sequential Sedation Patients in Intensive Care Unit NCT03194360 | West China Hospital | — |
| Completed | A Study Evaluating Pharmacodynamics, Pharmacokinetics, Safety and Tolerability of HSK3486 Single Bolus Dose Fo NCT04029766 | Sichuan Haisco Pharmaceutical Group Co., Ltd | Phase 1 |
| Completed | Evaluating the Safety, Pharmacodynamics and Pharmacokinetics of HSK3486 in Healthy Female Subjects. NCT04037657 | Sichuan Haisco Pharmaceutical Group Co., Ltd | Phase 1 |
| Unknown | Pilot Study for Sedation Interruption in Children NCT02426320 | Davinia Withington | N/A |
| Completed | Use of Clonidine to Prevent Withdrawal Following Prolonged Dexmedetomidine Infusions NCT02404077 | Joseph D. Tobias | — |
| Completed | The Utility of Pretracheal Stethoscope in Detecting Respiratory Abnormalities in Sedated Children NCT01957566 | University of Wisconsin, Madison | N/A |
| Completed | Electro-acupuncture and Flumazenil's Effect on Sedation NCT02690389 | Dr. Yin Liu | N/A |
| Completed | Intranasal Midazolam in Children as a Pre-Operative Sedative - Part 2 NCT02356705 | Jennifer Victory, RN, CCRC | Phase 4 |
| Unknown | Impact of a Nurse Implemented Sedation and Analgesia Algorithm in Surgical Intensive Care Unit NCT03186521 | University Hospital, Caen | — |
| Unknown | A Comparison Between Propofol and Etomidate in Hysteroscopy on Effect of Postoperative Sedation and Cognitive NCT02147678 | Shaanxi Provincial People's Hospital | Phase 4 |
| Unknown | Nurse Administered Propofol Sedation vs. Midazolam With Fentanyl-sedation for Flexible Bronchoscopy: A Randomi NCT02226328 | Copenhagen University Hospital at Herlev | Phase 4 |
| Completed | Sedation and Physiological Effects of Intranasal Dexmedetomidine in Severe COPD NCT02211118 | Dayton VA Medical Center | Phase 4 |
| Terminated | Comparison of Outcomes During MRI Sedation With Midazolam-dexmedetomidine Versus Ketamine-dexmedetomidine NCT02129426 | University of Louisville | N/A |
| Completed | Effects of Sedation on Spinal Anesthesia-induced Maternal Hypotension NCT02732197 | Van Training and Research Hospital | — |
| Unknown | Interventional Bronchoscopy Under Noninvasive Ventilation NCT02289586 | Futian People's Hospital | N/A |
| Completed | A Study Evaluating the Safety, Pharmacodynamics and Pharmacokinetics of HSK3486 in Healthy Subjects. NCT04033939 | Sichuan Haisco Pharmaceutical Group Co., Ltd | Phase 1 |
| Completed | The Role of Melatonin in the Effective Attainment of Sleep Electroencephalograms (EEG) in Children NCT02195661 | University of Cape Town | Phase 3 |
| Completed | Propofol Administered by Gastroenterologists by Target Controlled Infusion Pump During Endoscopy NCT02062177 | Università Vita-Salute San Raffaele | Phase 4 |
| Completed | Satisfaction With Nurse Administered Propofol Sedation vs. Midazolam With Fentanyl Sedation for Endoscopy NCT01934088 | Copenhagen University Hospital at Herlev | Phase 4 |
| Completed | Assessment of Sedation During Endoscopy NCT01747733 | Helsinki University Central Hospital | — |
| Completed | Dexmedetomidine PKPD Modeling and the Influence of Auditory Stimulation on Dexmedetomidine Effect NCT01879865 | University Medical Center Groningen | N/A |
| Completed | Randomized Trial of Diphenhydramine Versus Continued Midazolam in "Difficult-to-sedate" Patients Undergoing Co NCT01769586 | VA Connecticut Healthcare System | N/A |
| Completed | EUROpean Pain Audit In Neonates NCT01694745 | Hôpital Armand Trousseau | — |
| Completed | Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care NCT01431326 | Daniel Benjamin | — |
| Completed | A Trial Of Oral Chloral Hydrate Versus Intranasal Dexmedetomidine For Sedated Abr Exams NCT01255904 | Baylor College of Medicine | Phase 4 |
| Completed | Clinical Study to Investigate the Efficacy and the Safety of DA-9501 in Sedation During the Surgery or Medical NCT01438931 | Hospira, now a wholly owned subsidiary of Pfizer | Phase 3 |
| Completed | Clinical Study to Investigate the Efficacy and the Safety of DA-9501 in Sedation During the Surgery With Epidu NCT01438957 | Pfizer | Phase 3 |
| Completed | Phase II Pharmacokinetic and Pharmacodynamic Study of DEX in Subjects Aged 12 Months Through <24 Months NCT01378988 | Hospira, now a wholly owned subsidiary of Pfizer | Phase 2 |
| Terminated | Intranasal Ketamine Versus Intramuscular Ketamine for Procedural Sedation in Pediatric Patients NCT01170247 | University of Iowa | N/A |
| Unknown | Evaluation of Sedation in Newborns NCT01265186 | Medical University of Vienna | — |
| Unknown | Comparing the Outcome of Two Intraoperative Analgesia Techniques After Hepato-pancreato-biliary Surgery NCT01201499 | Tel-Aviv Sourasky Medical Center | N/A |
| Unknown | Sedation of Mechanically Ventilated Critically Ill Patients: Midazolam Versus Dexmedetomidine NCT01256866 | Hospital Sao Domingos | Phase 4 |
| Completed | Comparing the Effect of Dexmedetomidine With Midazolam on Sedation, Oxidative Stress, and Microcirculation in NCT00886275 | National Taiwan University Hospital | Phase 4 |
| Completed | Safety, Efficacy and Pharmacokinetic Study of Dexmedetomidine in Pediatrics Ages ≥28 Weeks to ≤44 Weeks Gestat NCT01159262 | Hospira, now a wholly owned subsidiary of Pfizer | Phase 2 / Phase 3 |
| Completed | Alternative Sedation During Bronchoscopy NCT01158820 | University of Pennsylvania | Phase 4 |
| Completed | Combination Ketamine and Propofol vs Propofol for Emergency Department Sedation: A Prospective Randomized Tria NCT01269307 | University of Utah | N/A |
| Completed | Multiple Dose Safety and Efficacy Study Evaluating CNS 7056 Versus Midazolam in Patients Undergoing Colonoscop NCT01145222 | Paion UK Ltd. | Phase 2 |
| Completed | A Dose-ranging Study to Evaluate the Safety and Efficacy of LUSEDRA (Fospropofol Disodium) as an Intravenous S NCT01127438 | Eisai Inc. | Phase 4 |
| Completed | Target-controlled Infusion Versus Patient-controlled Sedation With Propofol in Endoscopic Retrograde Cholangio NCT01072435 | Helsinki University Central Hospital | Phase 4 |
| Unknown | Dexmedetomidine Versus Midazolam for Intensive Care Sedation of Children NCT01091818 | Ullevaal University Hospital | Phase 3 |
| Withdrawn | Phase I, Single Centre, Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD3043 NCT01086813 | AstraZeneca | Phase 1 |
| Completed | Study Evaluating Safety and Efficacy of Dexmedetomidine (DEX) in Intubated and Mechanically Ventilated Pediatr NCT00875550 | Hospira, now a wholly owned subsidiary of Pfizer | Phase 3 |
| Withdrawn | Dexmedetomidine Versus Pentobarbital for Pediatric Procedural Sedation NCT00878345 | Washington University School of Medicine | N/A |
| Completed | Propofol Versus Alfentanil Versus Nitrous Oxide for Moderate Procedural Sedation NCT00997126 | Hennepin Healthcare Research Institute | Phase 4 |
| Completed | Stress During Deep Sedation With Propofol With and Without Alfentanil NCT00997113 | Hennepin Healthcare Research Institute | Phase 4 |
| Completed | A Comparison Between Propofol-Remifentanil and Midazolam-Remifentanil Sedation in the Intensive Care Unit NCT01527903 | Yonsei University | Phase 4 |
| Completed | Assess the Ability of Electrical Cardiometry to Trend Hemodynamic Variables During Dexmedetomidine Sedation NCT01001533 | Boston Children's Hospital | — |
| Completed | Effect of Nitrous Oxide (N2O) on Intraocular Pressure in Healthy Volunteers NCT00967694 | Oregon Health and Science University | Phase 4 |
| Completed | Bispectral Index Monitoring of Sedation During Endoscopic Retrograde Cholangiopancreaticography NCT00952458 | Technical University of Munich | N/A |
| Completed | A Study to Evaluate the Clinical Efficacy, Safety and Tolerability of ARX-F03 Sublingual Sufentanil/Triazolam NCT00894699 | Talphera, Inc | Phase 2 |
| Terminated | Non-pharmacological Intervention for Colonoscopy NCT00913861 | University Hospital, Geneva | N/A |
| Completed | SWC on aEEG in Post-surgical Neonates on Morphine and Midazolam NCT01212419 | Royal Children's Hospital | — |
| Completed | Bioavailability of Dexmedetomidine After Intranasal Administration NCT00837187 | University of Turku | Phase 1 |
| Withdrawn | Adjunct Dexmedetomidine (Precedex®) Therapy Impact on Sedative and Analgesic Requirement NCT00852046 | Avera McKennan Hospital & University Health Center | Phase 4 |
| Completed | Randomized Study With Midazolam for Sedation in Flexible Bronchoscopy NCT01038882 | Hospital Universitario La Fe | N/A |
| Completed | Pharmacokinetics of Dexmedetomidine During Prolonged Infusion in ICU NCT00747721 | Orion Corporation, Orion Pharma | Phase 1 |
| Completed | Surgical Stress Index as a Tool for Monitoring Analgesia and/or Sedation in Critically Ill Patients NCT00789412 | University Hospital Schleswig-Holstein | — |
| Completed | Safe Administration of Propofol for Sedation in Children NCT00832013 | University of British Columbia | N/A |
| Terminated | Correlation of Cerebral State Index With the Richmond Agitation-Sedation Scale in Mechanically Ventilated ICU NCT00855075 | CAMC Health System | — |
| Completed | Pharmacokinetic of Sevoflurane During a 48h Sedation in Intensive Care Unit With AnaConDa® NCT01196754 | University Hospital, Clermont-Ferrand | N/A |
| Completed | Long-term Clinical Study Evaluating the Safety and Efficacy of Dexmedetomidine in ICU Subjects NCT00526760 | Hospira, now a wholly owned subsidiary of Pfizer | Phase 3 |
| Completed | Dexmedetomidine Cardiovascular Safety in Pediatric Burn Patients NCT00697788 | Massachusetts General Hospital | Phase 2 |
| Completed | Propofol Versus Ketamine for Moderate Procedural Sedation in the Emergency Department (ED) NCT00997321 | Hennepin Healthcare Research Institute | Phase 4 |
| Terminated | Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms NCT00409344 | Massachusetts General Hospital | Phase 4 |
| Terminated | A Study Comparing Two Analgesia/Sedation Regimens, Remifentanil/Propofol Versus Sufentanil/Propofol In Mechani NCT00421720 | GlaxoSmithKline | Phase 4 |
| Completed | Use of Dexmedetomidine for Sedation During Flexible Bronchoscopy in Patients With COPD: A Descriptive Study NCT00401206 | The Cooper Health System | N/A |
| Terminated | Pharmacokinetics of Low Dose Ketamine Infusion NCT00618397 | University of Texas Southwestern Medical Center | Phase 1 |
| Completed | A Trial Comparing Propofol to Midazolam Plus Meperidine Sedation for Outpatient Colonoscopy NCT00848861 | University of Alberta | N/A |
| Completed | Acute Neurological ICU Sedation Trial (ANIST) NCT00390871 | Johns Hopkins University | Phase 2 |
| Completed | Clonidine-Remifentanil. Effect of the Combination on Acute Pain and Respiration in Healthy Volunteers NCT00730054 | Oslo University Hospital | Phase 1 / Phase 2 |
| Completed | Use of the SNAP II Electroencephalography (EEG) Monitor in Outpatients Undergoing Surgery/Procedures With Seda NCT00204711 | University of Wisconsin, Madison | — |
| Completed | Pharmaco-Economic Study Of Ultiva In Intensive Care Unit(ICU)Subjects NCT00158873 | GlaxoSmithKline | Phase 4 |
| Terminated | Sedation and Psychopharmacology in Critical Care NCT00205517 | Virginia Commonwealth University | N/A |
| Available | Expanded Access for Inhaled Isoflurane Delivered Via the Sedaconda ACD-S for Sedation of Difficult-to-Sedate A NCT07457593 | Sedana Medical | — |
| Completed | A Study to Assess the Analgesia and Sedation Using Intranasal Dexmedetomidine in Third Molar Surgery Under Loc NCT01132794 | The University of Hong Kong | Phase 3 |