Pleural Effusion

150 registered clinical trials studyying Pleural Effusion — 20 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	Evaluation of Transthoracic Ultrasonography in Differentiating Pleural Effusions NCT07513909	Assiut University	—
Recruiting	Evaluation of the Efficacy of Diagnostic Support Algorithms in Chest X-rays- LuAna Trial NCT06686251	Hospital Israelita Albert Einstein	N/A
Active Not Recruiting	Study of the Benefits of Virtual Reality Headsets for Reducing Anxiety in Patients Treated for Pleural Effusio NCT07206940	Centre Hospitalier Universitaire de Nice	N/A
Recruiting	Effect of Bubble Positive Expiratory Pressure and Segmental Breathing Versus Incentive Spirometry in Pleural E NCT07248774	Riphah International University	N/A
Not Yet Recruiting	Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema NCT07095361	University of North Carolina, Chapel Hill	Phase 4
Recruiting	Pleural Effusion Biomarkers in Lung Adenocarcinoma Patients NCT07012759	Fu Jen Catholic University	—
Recruiting	16F vs 24F Chest Drain After Minimally Invasive Lobectomy and/or Segmentectomy NCT06958848	University Hospital, Basel, Switzerland	N/A
Recruiting	ARMSTRONG - Air entRainMent vS sTandard tReatment in nOn-expandable luNG NCT06959719	Cambridge University Hospitals NHS Foundation Trust	N/A
Recruiting	Pleuroscopy First Versus Thoracentesis First in Patients With Suspected Malignant Pleural Effusions NCT06892691	Icahn School of Medicine at Mount Sinai	N/A
Recruiting	Confocal Laser Endomicroscopy Guided Medical Thoracoscopy for the Diagnosis of Pleural Disease NCT06741839	China-Japan Friendship Hospital	N/A
Not Yet Recruiting	Chest Drain Insertion Assisted by Virtual Reality NCT06589739	Central Hospital, Nancy, France	N/A
Completed	TBP Survey Among Respiratory Physicians NCT06390969	Chinese University of Hong Kong	—
Completed	PMCF Study of the CE-marked Drainova® ArgentiC Catheter NCT06436807	ewimed GmbH	—
Active Not Recruiting	The ACES Study for Aseptic Pleural Effusion NCT06210685	Pleural Dynamics, Inc.	N/A
Unknown	Medical Thoracoscopy for Diagnosing Unexplained Pleural Effusion: a National Multicenter Retrospective Study NCT06275178	China-Japan Friendship Hospital	—
Recruiting	Normal Saline Flushing With And Without Heparin Lock In Maintaining Small Bore Intercostal Chest Catheter (ICC NCT06314620	National University of Malaysia	N/A
Recruiting	Improvement to Perform Thoracocentesis After a Specific Training in Medical Students With the Supervised Use o NCT05960747	University Hospital, Strasbourg, France	—
Recruiting	Virtual Reality: Distraction During Small Bore Intercostal Chest Drain Insertion NCT06247800	National University of Malaysia	N/A
Completed	Medical Thoracoscopy With Flexible Bronchoscopy Versus Semi-Rigid Pleuroscope in Pleural Effusion (FLEXPLEUR) NCT06162429	National University of Malaysia	—
Recruiting	Strategy for Prompt and Effective Thoracentesis in the Emergency Department NCT06180603	University of Aarhus	N/A
Recruiting	Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU NCT06538376	Brigham and Women's Hospital	N/A
Unknown	The INSIGHT Feasibility Study Ultrasound in the Intensive Care Unit: A Randomised Controlled Feasibility Trial NCT05569798	King's College Hospital NHS Trust	N/A
Not Yet Recruiting	Ultrasound-guided Pigtail Catheter Versus Intercostal Tube Drainage of Non-traumatic Exudative Pleural Effusio NCT06099054	Assiut University	N/A
Unknown	Continuation Of a Study to Investigate the Effect of Thoracocentesis on Neural Respiratory Drive in Pleural Ef NCT05945043	Guy's and St Thomas' NHS Foundation Trust	—
Completed	AI Assisted Detection of Chest X-Rays NCT06075836	Oxford University Hospitals NHS Trust	—
Completed	Enhancing Respiratory Auscultation Skills Among Medical Students: Digital Stethoscopes in Medical Education NCT06359158	Chung Shan Medical University	N/A
Recruiting	Comparing the Diagnostic Sensitivity and Specificity of Pleural Fluid N-Terminal Pro B-type Natriuretic Peptid NCT05797649	Chinese University of Hong Kong	—
Unknown	Validity of Pleural Effusion Detection Software NCT05903287	Chang Gung Memorial Hospital	—
Recruiting	First Local Anaesthesia Thoracoscopy for Pleural Effusion Diagnosis. NCT06946498	National and Kapodistrian University of Athens	N/A
Unknown	The Effectiveness and Safety of Ultrasound Elastography Guided Pleural Biopsy in the Differential Diagnosis of NCT05781659	China-Japan Friendship Hospital	N/A
Unknown	Diagnostic Yield of Agitated Exudative Non-infected Pleural Effusion NCT05819294	Alexandria University	N/A
Unknown	A Prospective Observational Study on the Role of Transthoracic Ultrasound in Differentiating Tuberculous From NCT05935696	Sarawak General Hospital	—
Unknown	Clinical Validation of Programmable Drain Fluid Regulator to Reduce Morbidity, Care Requirements, and Improve NCT05734729	Changi General Hospital	N/A
Unknown	Efficacy of Topical Lidocaine/Prilocaine in Pain Management in Pleurocentesis NCT05984264	Assiut University	Phase 4
Not Yet Recruiting	Role of Ultrasound Elastography in Pleural Effusion NCT05642091	Assiut University	N/A
Unknown	Pigtail Catheter for Drainage of (Pneumothorax/Simple Effusion) is a Effective Procedure NCT05641779	Assiut University	—
Completed	Quantitative C-Reactive Protein for Differentiating Tuberculous and Malignant Pleural Effusion: a Cross-Sectio NCT06729931	Maharajgunj Medical Campus	—
Completed	Multi-Reader Retrospective Study Examining Carebot AI CXR 2.0.21-v2.01 Implementation in Everyday Radiology Cl NCT05963945	Carebot s.r.o.	—
Unknown	Collection of Pleural Effusion Fluid NCT05539183	Universitair Ziekenhuis Brussel	N/A
Unknown	Prospective Evaluation of Patients With Pleural Effusion NCT05759117	Chinese University of Hong Kong	—
Completed	Retrospective Study of Carebot AI CXR Performance in Preclinical Practice NCT05594485	Carebot s.r.o.	—
Completed	Efficacy of the echOpen Device to Identify Effusion and to Detect Basilic Vein NCT05280119	Assistance Publique - Hôpitaux de Paris	N/A
Completed	Thoracentesis QI Study NCT05424120	University of Minnesota	N/A
Unknown	Urine Bag Usage Versus Chest Drain Clamping After Lung Resection Surgeries NCT05230420	Al-Quds University	N/A
Unknown	Local Anesthesia Versus Combined Local Anesthesia With Single Dose Analgesia on Pain Control During Thoracic U NCT05121233	Assiut University	Phase 4
Completed	Point of Care Ultrasound Lung Artificial Intelligence (AI) Validation Data Collection Study NCT04891705	Philips Clinical & Medical Affairs Global	—
Completed	Thoracentesis to Alleviate Cardiac Pleural Effusion NCT05017753	Bispebjerg Hospital	N/A
Unknown	Multicenter Validation Study of an Artificial Intelligence Tool for Automatic Classification of Chest X-rays NCT04991987	Hospital Italiano de Buenos Aires	—
Completed	The Oxford Pleural Infection Endotyping Study NCT06513689	University of Oxford	—
Completed	Intrapleural Fibrinolytic Therapy to Enhance Chemical Pleurodesis Enhance Chemical Pleurodesis NCT04806373	Memorial Healthcare System	Phase 4
Unknown	Evaluation and Importance of the PD-1/PD-L1 and the IL-10/IL-10R Axis in Malignant and Benign Pleural Effusion NCT04834830	University of Vienna	—
Completed	Investigating Signal Change in Malignant and Non-malignant Pleural Effusions and asCitic Fluid Using fTiR Anal NCT04533854	Portsmouth Hospitals NHS Trust	—
Unknown	Diagnosis and Classification of Pleural Diseases Using Ultrasound Channel Data NCT04418804	Israel Aharoni	N/A
Unknown	Modified Thoracoscopic Pleural Cryobiopsy in Diagnosis of Exudative Pleural Effusion NCT04683419	Alexandria University	N/A
Completed	A Study to Evaluate LTI-01 in Patients With Infected, Non-draining Pleural Effusions NCT04159831	Rein Therapeutics	Phase 2
Unknown	Prospective Data Collection on Clinical, Radiological and Patient Reported Outcomes After Pleural Intervention NCT05910112	University of Oxford	—
Completed	Thoracic Drains in Intensive Care Units: Comparison of Seldinger and Surgical Methods NCT04438317	University Hospital, Clermont-Ferrand	N/A
Completed	Role of Cryobiopsy in Diagnosis of Pleural Effusion NCT03828903	Assiut University	N/A
Completed	Comparing Active Versus Passive Aspiration in Therapeutic Thoracentesis: Efficacy, Procedure Time, and Patient NCT07184736	Sheikh Zayed Federal Postgraduate Medical Institute	N/A
Unknown	Physical Therapy Intervention in Pleural Effusion NCT04294485	Universidad de Granada	N/A
Completed	Value of Additional Upfront Systematic Lung Ultrasound in the Workup of Patients With Unilateral Pleural Effus NCT04235998	Naestved Hospital	—
Unknown	Use of Guidance Videos to Increase Engagement and Decrease Anxiety in Patients Undergoing Pleural Tap NCT04254445	GistMed Ltd.	N/A
Completed	Thoracentesis: Symptoms and Prediction of the Need for Therapeutic Thoracentesis NCT04236934	Naestved Hospital	—
Unknown	Suturing With U-Technique Versus Un-Reapproximated Wound Edges During Removal of Closed Thoracostomy Tube Drai NCT04193241	University of Ibadan	N/A
Terminated	A Randomised Study Evaluating Diagnostics of Pleural Effusion Among Patients Suspect of Cancer. NCT04233359	Naestved Hospital	N/A
Completed	Evaluation of Ultra-portable Ultrasound in General Practice NCT04127149	Hospices Civils de Lyon	N/A
Terminated	Positive and Quantitative Diagnosis of Pleural Effusions by Thoracic Ultrasonography in Patients With Acute Re NCT03846934	University Hospital, Limoges	—
Completed	Clinical Implementation of the Use of Positive Pressure in Chest Drainage NCT03896672	Universidade Cidade de Sao Paulo	N/A
Unknown	Talc Outpatient Pleurodesis With Indwelling Catheter NCT03973957	The Cooper Health System	N/A
Completed	Safety and Efficacy of Coaxial Smart Drain (Redax TM) in Uniportal-VATS NCT06036667	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	N/A
Recruiting	Gravity Versus Vacuum Based Indwelling Tunneled Pleural Drainage System NCT03831386	Johns Hopkins University	N/A
Unknown	Evaluation and Outcome of Para-pneumonic Effusion NCT03480490	Assiut University	—
Withdrawn	The Safety and Efficacy of Fibrinolysis in Patients With an Indwelling Pleural Catheter for Multi-loculated Ma NCT03678090	Yale University	Phase 2
Unknown	Education and Training Competences in Thoracic Ultrasound NCT03728491	Odense University Hospital	N/A
Completed	Gravity- Versus Suction-driven Large Volume Thoracentesis NCT03591952	Vanderbilt University Medical Center	N/A
Withdrawn	Betadine Pleurodesis Via Tunneled Pleural Catheters NCT02975921	Yale University	Phase 4
Unknown	Ballooned Intercostal Drain Trial NCT03000504	Royal Brompton & Harefield NHS Foundation Trust	N/A
Unknown	Minirigid Versus Conventional Rigid Thoracoscopy in Undiagnosed Pleural Effusions NCT03449602	Post Graduate Institute of Medical Education and Research, Chandigarh	N/A
Unknown	Evaluation Of Pleural Effusion At Assiut University Hospital NCT03260088	Assiut University	—
Completed	The Safety of Thoracentesis, Tunneled Pleural Catheter, and Chest Tubes in Patients Taking Novel Oral Anti-Coa NCT03535883	Yale University	—
Completed	Novel Pleural Fluid, Biopsy and Serum Biomarkers for the Investigation of Pleural Effusions NCT03661801	University of Oxford	—
Completed	Point-of-care Ultrasound in Finland NCT03327688	Ossi Hannula	N/A
Unknown	Evaluating Different Modalities for Pleural Adhesiolysis at Assuit University Hospital NCT03172052	Assiut University	Phase 4
Unknown	Thoracic Ultrasound in the Treatment of Pleural Effusion NCT02505763	University Hospital, Toulouse	N/A
Completed	Noninvasive Ventilation Therapy for the Treatment of Pleural Effusion in Patients With Heart Failure NCT03189654	Heart and Diabetes Center North-Rhine Westfalia	—
Completed	Persistent Pleural Effusion Treatment Following Cardiothoracic Surgery by Platelet-Fibrin Glue NCT06449131	Daryoush Hamidi Alamdari, PhD	Phase 2
Completed	Data Visualization of Kidney and Prostate Tumors Using Routine Pre-Operative Imaging, 3D Printed, and 3D Virtu NCT03656822	NYU Langone Health	—
Completed	Pleural Effusion Drainage in Mechanically Ventilated Patients Monitored by EIT NCT03231072	Czech Technical University in Prague	N/A
Completed	Use of Vasopressin Following the Fontan Operation NCT02975999	Wake Forest University Health Sciences	Phase 2 / Phase 3
Completed	Pressure Levels on Lung Expansion NCT03027180	Universidade Cidade de Sao Paulo	N/A
Completed	Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program NCT03296280	VA Office of Research and Development	—
Unknown	Liquid Biopsy With Immunomagnetic Beads Capture Technique for Malignant Cell Detection in Body Fluid NCT02891642	The First Affiliated Hospital with Nanjing Medical University	—
Completed	Mini Thoracoscopy vs Semirigid Thoracoscopy in Exudative Pleural Effusions NCT02851927	All India Institute of Medical Sciences	N/A
Completed	Impact of Draining Significant Effusion on Gas Exchange and Lung Mechanics in Patient Under Mechanical Ventila NCT03394872	Dokuz Eylul University	—
Completed	Impact of Pleural Manometry on Chest Discomfort After Therapeutic Thoracentesis NCT02677883	Vanderbilt-Ingram Cancer Center	N/A
Unknown	International Registry of Patients Treated With Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) NCT03210298	Sabine Rhode	—
Withdrawn	Exploration of the Pleural Cavity Using a fleXible endoscoPe NCT02463955	University Hospital, Rouen	N/A
Completed	Vacuum vs Manual Drainage During Unilateral Thoracentesis NCT03496987	Yale University	N/A
Completed	Active Clearance of Chest Tubes After Cardiac Surgery: A Prospective Randomized Controlled Study NCT02808897	Montreal Heart Institute	N/A
Completed	Driving Pressure And EFL in Adult Cardiac Surgery NCT03064659	Ospedale San Raffaele	—
Unknown	Ketotifen as a Treatment for Vascular Leakage During Dengue Fever NCT02673840	National University Hospital, Singapore	Phase 4
Completed	Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy NCT02446782	Post Graduate Institute of Medical Education and Research, Chandigarh	Phase 4
Completed	Perioperative Change of Regional Ventilation During Spontaneous Breathing NCT02419196	Wuerzburg University Hospital	—
Completed	Yield of Cryoprobe vs Flexible Forceps Pleural Biopsy NCT02500277	Post Graduate Institute of Medical Education and Research, Chandigarh	N/A
Completed	Positive Airway Pressure on Pleural Effusion After Drainage NCT02246946	Universidade Cidade de Sao Paulo	N/A
Completed	Electrical Impedance Imaging of Patients on Mechanical Ventilation NCT02232841	Colorado State University	—
Completed	Pathophysiological Effects of Intrapleural Pressure Changes During Therapeutic Thoracentesis NCT02192138	Medical University of Warsaw	N/A
Terminated	Using Ultrasound to Predict the Results of Draining Pleural Effusions NCT01973985	University of Oxford	—
Terminated	Investigation Into the Automated Drainage of Recurrent Effusions From the Pleural Space in Thoracic Malignancy NCT01952327	Sequana Medical N.V.	N/A
Terminated	The Effect of Non-Steroidal Anti-Inflammatory Drug Naproxen on Pleural Effusion Formation After Lung Resection NCT01612975	McMaster University	Phase 2
Unknown	Diagnostic Accuracy of Pleural Effusion Aspergillosis Biomarker Testing NCT02104479	Heidelberg University	—
Unknown	Pigtail Catheter: a Less Invasive Option for Pleural Drainage of Recurrent Hepatic Hydrothorax NCT02119169	Sherief Abd-Elsalam	N/A
Completed	A Feasibility and Safety Study of the Use of a Dedicated Ballooned Intercostal Drain NCT01869504	Sherwood Forest Hospitals NHS Foundation Trust	N/A
Completed	Using Pleural Effusions to Diagnose Cancer NCT03319472	University of Patras	—
Completed	Pleural and Pericardial Effusion Following Open Heart Surgery NCT02045641	Aarhus University Hospital Skejby	N/A
Completed	Comparison of Pleural Drainage Systems on Reducing Pleural Effusion Formation Following Lung Resection NCT01776372	McMaster University	N/A
Completed	Tubeless Versus Standard Upper Pole Percutaneous Nephrolithotomy NCT02036398	Rabin Medical Center	N/A
Completed	Evaluation of a Pocket-Sized Ultrasound Device As an Aid to the Physical Examination NCT01948076	Brigham and Women's Hospital	N/A
Unknown	Effects of Pleural Effusion Drainage on Respiratory System Mechanics NCT01652521	Wolfson Medical Center	—
Unknown	Detection of Pleural Effusion by Internal Thoracic Impedance Method NCT01601444	Michal Roll PhD,MBA	N/A
Unknown	COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 NCT01552187	Maria Vittoria Hospital	Phase 3
Completed	Cryobiopsy or Forceps Biopsy During Semirigid Thoracoscopy: a Comparative Study NCT01475084	The University Clinic of Pulmonary and Allergic Diseases Golnik	Phase 2 / Phase 3
Completed	Not Invasive Monitoring of Pleural Drainage NCT01778270	RWTH Aachen University	N/A
Completed	Physiotherapy Technique Decreases Respiratory Complications After Cardiac Operation NCT01416519	Santa Casa de Votuporanga	N/A
Completed	Procoagulant Activity in Patients With Community Acquired Pneumonia, Pleural Effusion and Empyema NCT01178580	Meir Medical Center	—
Completed	Catheter Placement for Hepatic Hydrothorax NCT02595567	Washington University School of Medicine	N/A
Completed	Pleural Cryobiopsies During Semirigid Thoracoscopy: A New Technique NCT01472172	The University Clinic of Pulmonary and Allergic Diseases Golnik	EARLY_Phase 1
Unknown	Pneumonia and Empyema in Emergency Departments in Children NCT05274607	Association Clinique Thérapeutique Infantile du val de Marne	—
Withdrawn	Echocardiographic Examination Performed by Nurses in Cardiac Intensive Care Unit NCT00886548	Helse Nord-Trøndelag HF	—
Completed	The First Therapeutic Intervention in Malignant Pleural Effusion Trial NCT00896285	University of California, Davis	N/A
Completed	Effects of Respiratory Physiotherapy on Pleural Effusion NCT01756742	Universidad de Granada	N/A
Active Not Recruiting	Intrapleural Catheter Daily Versus Three Times a Week Drainage NCT00761618	M.D. Anderson Cancer Center	Phase 2
Terminated	Tenecteplase (TNK) for Loculated Pleural Effusions in Patients With Malignancy NCT01580618	Kaiser Permanente	Phase 2 / Phase 3
Unknown	Angiogenic Cytokines and Fibrinolytic Activity in Parapneumonic Effusions NCT01325454	Taipei Medical University Hospital	—
Completed	Sustained Effects of Thoracocentesis in Mechanically Ventilated Patients NCT00915161	Oxford University Hospitals NHS Trust	—
Completed	Drainage Amount for Removal of Thoracostomy Tube NCT00575198	University of California, Davis	N/A
Completed	Comparison of Thoracoscopic Talc Pleurodesis by Thoracic Epidural or General Anesthesia NCT01469728	University of Rome Tor Vergata	Phase 2
Completed	Vibration Response Imaging (VRI) in Management and Evaluation in Patients With Pleural Effusion NCT00473291	Deep Breeze	—
Terminated	Malignant Pleural Effusion With ZD6474 NCT00402896	M.D. Anderson Cancer Center	Phase 2
Completed	Efficacy Study of Thrice Weekly Directly Observed Treatment Short-Course Regimen in Tubercular Pleural Effusio NCT01560078	All India Institute of Medical Sciences	—
Terminated	Multiple Biomarkers in Undiagnosed Pleural Effusion NCT00316134	Fujirebio Diagnostics, Inc.	—
Completed	Rigid Thoracoscopy Versus CT-Guided Pleural Needle Biopsy NCT00720954	Eskisehir Osmangazi University	N/A
Completed	Reproducibility of Computed Tomography NCT01616264	Universidade Federal do Rio de Janeiro	—
Completed	PDMS Outcome After Intensive Care, Organdysfunction and Monitoring NCT03379688	Charite University, Berlin, Germany	—
Unknown	Use of the Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) in the Diagnosis of Pleural Effusion NCT00166894	National Taiwan University Hospital	—
Completed	Continuous Positive Airway Pressure on Tuberculosis Pleural Effusion NCT00560521	Universidade Federal do Rio de Janeiro	N/A
Unknown	Use of Procalcitonin in the Diagnosis of Pleural Effusion NCT00172835	National Taiwan University Hospital	—
Unknown	Alteplase for Treatment of Empyema and Complicated Parapneumonic Effusion NCT00103766	O'Brien, Jeana D., MD, FACP, FCCP	N/A
Completed	Pleural Effusion Following Cardiac Surgery: Prevalence, Risk Factors and Clinical Features NCT00665015	Laval University	—
Completed	Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic NCT01246453	Hospital Universitari Vall d'Hebron Research Institute	Phase 4