| Not Yet Recruiting | Evaluating the Clinical Effectiveness of Sodium Bicarbonate for Critically Ill Patients With Metabolic Acidosi NCT07464431 | Universität Münster | Phase 4 |
| Not Yet Recruiting | A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients NCT07424625 | Mayo Clinic | Phase 4 |
| Recruiting | A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic Acidosis NCT07355062 | Renibus Therapeutics, Inc. | Phase 3 |
| Recruiting | Adding Urea to the Final Dialysis Fluid NCT06366230 | University of California, San Francisco | Phase 1 / Phase 2 |
| Recruiting | A Study on Bedside Formate Assay as a Diagnostic Tool in Methanol Poisoning NCT06881641 | University of Edinburgh | — |
| Recruiting | Prevention of Metabolic Acidosis in Preterm Neonates by Replacing Sodium Chloride With Sodium Acetate in Paren NCT06545565 | Aga Khan University Hospital, Pakistan | Phase 3 |
| Recruiting | PLADO for Conservative Management of CKD NCT06932042 | Lebanese American University | N/A |
| Active Not Recruiting | Explorative Study to Investigate the Acid-base Response to Sodium and Potassium Salts in Patients With Chronic NCT06237712 | Erasmus Medical Center | N/A |
| Completed | Correlation Between Base Excess in Patients Upon Admission to the ICU and Platelet Count Trend in the Followin NCT06908408 | University Medical Centre Ljubljana | — |
| Recruiting | Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD NCT04984226 | University of California, Davis | Phase 2 |
| Active Not Recruiting | Reducing Dietary Acid With Food Versus Oral Alkali in People With Chronic Kidney Disease (ReDACKD) NCT05113641 | Dylan MacKay | N/A |
| Completed | The Relationship of Developing Metabolic Acidosis With Antiepleptic Drugs in Craniotomy Operations NCT05940935 | Trakya University | — |
| Active Not Recruiting | SODium BICarbonate for Metabolic Acidosis in the ICU NCT05697770 | Australian and New Zealand Intensive Care Research Centre | Phase 3 |
| Unknown | ADVOS® Versus CVVHD in Metabolic or Mixed Acidosis NCT05842369 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Unknown | Reduction of Metabolic Acidosis in Patients With Chronic Kidney Disease in Stage 4 and 5 NCT05784389 | Nordsjaellands Hospital | N/A |
| Completed | Reduction of Metabolic Acidosis in Patients With Chronic Kidney Disease in Stage 4 and 5 NCT05970094 | University of Copenhagen | N/A |
| Unknown | Lactate Metabolism in the Hypoperfused Critically Ill NCT05582824 | University of Copenhagen | — |
| Unknown | Value of Fetal Scalp Lactate Sampling During Labour in Cases of Abnormal Fetal Heart Rate NCT05259202 | University Hospital, Montpellier | — |
| Recruiting | Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant Recipients NCT05005793 | University of Colorado, Denver | Phase 4 |
| Completed | Meglimine Sodium Succinate for Correction of Metabolic Acidosis in Critically Ill Patients NCT05147051 | POLYSAN Scientific & Technological Pharmaceutical Company | Phase 2 |
| Terminated | Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metaboli NCT04727528 | AstraZeneca | Phase 3 |
| Completed | Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD NCT04600323 | University of Colorado, Denver | EARLY_Phase 1 |
| Completed | Diabetic Ketoacidosis Diagnosis and Management NCT06327737 | Akdeniz University | — |
| Completed | Sodium Bicarbonate for the Treatment of Severe Metabolic Acidosis With Moderate or Severe Acute Kidney Injury NCT04010630 | University Hospital, Montpellier | N/A |
| Withdrawn | High Versus Low Bicarbonate Bath in Critically-ill Patients Receiving Continuous Renal Replacement Therapy NCT03846258 | Mayo Clinic | Phase 4 |
| Unknown | Inflammation and Metabolic Acidosis at Birth (AGAIN: AutophaGy AcIdosis Newborn) NCT03897101 | University Hospital of Ferrara | — |
| Completed | Bicarbonate Administration in Kidney Transplant Recipients NCT03428464 | University of Colorado, Denver | N/A |
| Terminated | Evaluation of Effect of TRC101 on Progression of Chronic Kidney Disease in Subjects With Metabolic Acidosis NCT03710291 | Tricida, Inc. | Phase 3 |
| Unknown | Use of Sodium Bicarbonate in Patients Treated With Topiramate NCT03354507 | McMaster Children's Hospital | N/A |
| Completed | Long-term Safety Extension to Study TRCA-301 NCT03390842 | Tricida, Inc. | Phase 3 |
| Completed | Evaluation of TRC101 in Subjects With Metabolic Acidosis Associated With Chronic Kidney Disease NCT03317444 | Tricida, Inc. | Phase 3 |
| Completed | The Threshold of Serum Anion Gap as a Screening Tool for Organic Acidosis NCT04975906 | Changi General Hospital | — |
| Completed | Alkalinization by Urologists & Nephrologists NCT03035812 | Jean-Philippe Bertocchio | Phase 4 |
| Completed | Bicarbonate Administration in CKD NCT02915601 | University of Colorado, Denver | N/A |
| Completed | Intraoperative Cell Salvage and Postoperative Acidosis NCT02800343 | University of Edinburgh | — |
| Completed | Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill NCT02476253 | University Hospital, Montpellier | Phase 3 |
| Completed | Bicarbonate in Patients With Out-of-hospital Cardiac Arrest NCT02303548 | Asan Medical Center | Phase 2 |
| Unknown | Correction of Metabolic Acidosis in End Stage Renal Disease (ESRD) NCT01640119 | Azienda Sanitaria ASL Avellino 2 | Phase 3 |
| Completed | Comparison of High Versus Low Bicarbonate Hemodialysis NCT02098356 | Albert Einstein College of Medicine | N/A |
| Completed | Metabolic Acidosis and Vascular Function in Patients With Chronic Kidney Disease NCT02031770 | University of Colorado, Denver | N/A |
| Terminated | Efficacy, Safety Study and Benefit of Alkali Therapy in Sickle Cell Disease NCT01894594 | University Hospitals Cleveland Medical Center | Phase 1 |
| Completed | Acid-Base Balance, Metabolism and Minerals NCT04229069 | Charite University, Berlin, Germany | N/A |
| Completed | Comparison of Standard Versus Low Bicarbonate Hemodialysis NCT01777178 | Albert Einstein College of Medicine | Phase 1 |
| Unknown | Incidence of Postoperative Ketosis and Metabolic Acidosis NCT01860001 | Royal Marsden NHS Foundation Trust | — |
| Unknown | Autologous Stem Cells in Newborns With Oxygen Deprivation NCT01506258 | Hospital Universitario Dr. Jose E. Gonzalez | N/A |
| Completed | Alkali Therapy in Chronic Kidney Disease NCT01452412 | Albert Einstein College of Medicine | Phase 2 / Phase 3 |
| Completed | Perioperative Fluid Management in Patients Receiving Cadaveric Renal Transplants NCT01075750 | Medical University of Vienna | — |
| Completed | Effect of Propofol and Sevoflurane on Lactate During Anesthesia for Pediatric Heart Catheterisation NCT01293266 | University Hospital Schleswig-Holstein | N/A |
| Completed | Substitution of Propofol by Sevoflurane During Pediatric Cardiopulmonary Bypass NCT01295190 | University Hospital Schleswig-Holstein | — |
| Completed | Metabolic Acidosis in Renal Transplant Patients NCT00913796 | University of Zurich | Phase 2 |