NCT02098356

Comparison of High Versus Low Bicarbonate Hemodialysis

Intradialytic Acid-base Changes and Organic Anion Production With High Versus Low Bicarbonate Hemodialysis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 7 (actual)
• Sponsor: Albert Einstein College of Medicine · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

This study will compare hemodialysis treatment with a standard, high-bicarbonate dialysis bath versus a lower bicarbonate dialysis bath, and will compare intradialytic acid-base changes and overall control of metabolic acidosis with the 2 treatment regimens.

Detailed description

This study will compare hemodialysis treatment with a standard, high-bicarbonate dialysis bath versus a lower bicarbonate dialysis bath, and will compare intradialytic acid-base changes and overall control of metabolic acidosis with the 2 treatment regimens. These parameters will be assessed in patients currently receiving high-bicarbonate hemodialysis as part of usual care. They will then be switched to a lower bicarbonate prescription, after which these parameters will be reassessed. The study will also examine changes in inflammatory markers, glycemic control, ketogenesis, and lipolysis.

Conditions

• Chronic Kidney Disease
• End-stage Renal Disease
• Metabolic Acidosis

Interventions

Type	Name	Description
OTHER	Low Bicarbonate	Low bicarbonate hemodialysis - 30 mEq/L dialysate bicarbonate

Timeline

• Start date: 2014-03-01
• Primary completion: 2015-12-01
• Completion: 2016-12-01
• First posted: 2014-03-28
• Last updated: 2019-07-05

Locations

1 site across 1 country: United States