Trials / Completed
CompletedNCT03428464
Bicarbonate Administration in Kidney Transplant Recipients
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 20 (actual)
- Sponsor
- University of Colorado, Denver · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Metabolic acidosis is associated with vascular endothelial dysfunction and is a common complication in patients who have received a kidney transplant. Kidney transplant recipients (KTR) with lower serum bicarbonate levels, even within the normal range, have an increased risk of graft loss and mortality. The investigators propose a prospective, double-blind, randomized, placebo-controlled, 18-week crossover pilot study to examine the effects of sodium bicarbonate on vascular endothelial function, graft function, and cognitive function in 20 KTR patients.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Sodium Bicarbonate | Participants will take ½ the daily dose of sodium bicarbonate in the morning and the other ½ in the evening. |
| OTHER | Placebo | Participants will take ½ the daily dose of a placebo in the morning and the other ½ in the evening. |
Timeline
- Start date
- 2018-12-05
- Primary completion
- 2020-03-25
- Completion
- 2020-03-25
- First posted
- 2018-02-09
- Last updated
- 2020-10-22
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT03428464. Inclusion in this directory is not an endorsement.