NCT03354507

Use of Sodium Bicarbonate in Patients Treated With Topiramate

Use of Sodium Bicarbonate to Alkalinize Serum/Urine in Pediatric Patients Treated With Topiramate (Pilot Study)

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: McMaster Children's Hospital · Academic / Other
• Sex: All
• Age: 2 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

Effect of oral sodium bicarbonate therapy on renal tubular acidosis in epilepsy patients taking topiramate.

Detailed description

Children on topiramate are at a risk of renal tubular acidosis and subsequent development of renal stones. Sodium bicarbonate has been shown to reduce renal tubular acidosis in other populations. To date, no data exist on the efficacy of correction of renal tubular acidosis in pediatric patients on topiramate. We are proposing to investigate the efficacy of 4 weeks of oral sodium bicarbonate therapy to reduce tubular acidosis in patients on topiramate.

Conditions

• Epilepsy
• Metabolic Acidosis
• Tubular Acidosis; Renal

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Sodium bicarbonate	Sodium bicarbonate. See arms.

Timeline

• Start date: 2018-01-01
• Primary completion: 2018-12-01
• Completion: 2018-12-01
• First posted: 2017-11-28
• Last updated: 2017-11-28

Locations

1 site across 1 country: Canada