NCT04229069

Acid-Base Balance, Metabolism and Minerals

Randomized, Double-blind, Placebo-controlled Intervention Study on Effects of Basica® on Acid-base Balance, Metabolism and Quality of Life in Elderly Healthy Volunteers.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Charite University, Berlin, Germany · Academic / Other
• Sex: All
• Age: 60 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Metabolism is controlled by macro- and micronutrients. Protein-rich diets should lead to latent acidosis at tissue level with further negative implications. Food supplements with alkaline salts are available and popular pretending to prevent these changes. Within a randomized double-blind placebo-controlled trial, the investigators tested the hypotheses 1) that a 4-week protein-rich diet induces a latent tissue acidosis and 2) an alkaline supplement can compensate this. Acid-base balance and important metabolic parameters were determined before and after 4 weeks of supplementation by peripheral blood samples, indirect calorimetry and muscle microdialysis before and after a protein-rich test meal.

Conditions

• Acid-Base Balance Disorder
• Metabolic Acidosis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	alkaline salt mixture	blood and tissue alkalinisation
DIETARY_SUPPLEMENT	placebo	no blood and tissue alkalinisation

Timeline

• Start date: 2013-01-03
• Primary completion: 2014-12-30
• Completion: 2015-12-30
• First posted: 2020-01-14
• Last updated: 2020-01-22