NCT05940935

The Relationship of Developing Metabolic Acidosis With Antiepleptic Drugs in Craniotomy Operations

The Relationship of Developing Metabolic Acidosis With Antiepleptic Drugs in Craniotomy Operations; Does Topiramat or Zonisamide Cause Metabolic Acidosis?

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 35 (actual)
• Sponsor: Trakya University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The relationship of developing metabolic acidosis with antiepleptic drugs in craniotomy operations

Detailed description

Metabolic acidosis is a life-threatening complication in the perioperative, intraoperative and postoperative period. It can cause decreased cardiac output, electrolyte imbalance, surgical bleeding and neurological complications, even coma and death in surgical patients. Topiramate and zonisamide are sulfonamide derivative compounds used in the treatment of epilepsy. It has been shown in studies that both drugs have a strong inhibition of carbonic anhydrase enzyme. Recent case reports suggest that both drugs may cause metabolic acidosis by lowering serum bicarbonate levels in some patients. Aim in this study is to determine the relationship between preoperative, intraoperative and postoperative metabolic acidosis and to emphasize the importance of anesthesia management in patients who have undergone craniotomy and use antiepileptic drugs.

Conditions

• Metabolic Acidosis
• Antiepileptic Drugs
• Craniotomy
• Anesthesia Management

Interventions

Type	Name	Description
PROCEDURE	Arterial Blood Gas Base Deficit	The base deficit values in the preoperative, intraoperative and postoperative blood gases taken from the patients and the presence and severity of metabolic acidosis were evaluated. Metabolic acidosis severity was defined by base deficit levels: mild from -3 to -5, moderate from -5 to -10, and severe metabolic acidosis below -10.

Timeline

• Start date: 2023-05-22
• Primary completion: 2023-06-30
• Completion: 2023-08-15
• First posted: 2023-07-11
• Last updated: 2023-11-07

Locations

1 site across 1 country: Turkey (Türkiye)