| Not Yet Recruiting | Safety and Effectiveness of TETRANITE Bone Adhesive for Cranial Flap Fixation Compared to Traditional Metal Ha NCT07452549 | RevBio | N/A |
| Recruiting | Analysis of Cerebrospinal Fluid Leakage After Surgery for Intracranial Tumors NCT07411690 | Medical University of Warsaw | — |
| Enrolling By Invitation | Post Market Study of Tutopatch In Craniotomy NCT07118020 | RTI Surgical | — |
| Recruiting | Dexmedetomidine as an Adjuvant to Bupivacaine in Scalp Block Versus Bupivacaine Alone for Postoperative Pain M NCT06993922 | Ain Shams University | N/A |
| Recruiting | A Pilot Clinical Study to Evidence Improved Cranial Flap Fixation With a Bioresorbable Bone Adhesive NCT06780852 | RevBio | N/A |
| Not Yet Recruiting | Efficacy and Safety of Non-sedation Trial in Patients After Neurosurgical Craniotomy NCT06727435 | Beijing Tiantan Hospital | N/A |
| Enrolling By Invitation | Effectiveness of 3D Bone Matrix in Cranioplasty NCT06792864 | Universidad Austral de Chile | Phase 3 |
| Active Not Recruiting | A Pilot Study to Evidence Improved Cranial Flap Fixation With a Bioresorbable Bone Adhesive NCT06095531 | RevBio | N/A |
| Completed | Dexmedetomidine as an Adjuvant to Bupivacaine in Scalp Block vs Bupivacaine Alone for Hemodynamics Stability i NCT06951256 | Ain Shams University | N/A |
| Unknown | EEG Spectrogram-guided vs. Index-guided Anesthesia for Craniotomy NCT06244017 | National Taiwan University Hospital | N/A |
| Recruiting | Preoperative Evaluation of IVC Collapsibility Index and Caval Aorta Index After Induction of General Anesthesi NCT07399093 | Ain Shams University | — |
| Unknown | Effect of SNB on the QoR in Patients Undergoing Supratentorial Tumor Resection NCT06157359 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Unknown | A Greek-designed ERAS Protocol in Elective Craniotomy NCT05962684 | University of Thessaly | — |
| Completed | The Relationship of Developing Metabolic Acidosis With Antiepleptic Drugs in Craniotomy Operations NCT05940935 | Trakya University | — |
| Completed | Propofol-remifentanyl Versus Dexmedetomidine in Awake Craniotomy: Impact on Electroclinical Seizure Activity NCT05103735 | Azienda Sanitaria-Universitaria Integrata di Udine | — |
| Recruiting | Study on Prognosis of Acutely Ruptured Intracranial Aneurysms NCT05851989 | Haaglanden Medical Centre | — |
| Completed | The Use of Eye Patches and Earplugs in Intensive Care in Cases of Craniotomy. NCT04959968 | Taksim Egitim ve Arastirma Hastanesi | N/A |
| Completed | Bone Flap Fixation Systems For Craniotomy Procedures NCT04859907 | NEOS Surgery | N/A |
| Completed | Postoperative Pain in Scheduled Craniotomy NCT04720248 | Dr. Negrin University Hospital | — |
| Completed | REDUCE Trial: Perineural Dexamethasone on Scalp Nerve Blocks NCT04648358 | Beijing Tiantan Hospital | N/A |
| Recruiting | Prospective, Observational Real-world Treatments of AEDH in Large-scale Surgical Cases NCT04229966 | RenJi Hospital | — |
| Completed | Impact of Severe Intraoperative Hyperglycemia on Infection Rate After Elective Intracranial Interventions NCT04285359 | Burdenko Neurosurgery Institute | — |
| Active Not Recruiting | Prospective Randomized Evaluation of Decompressive Ipsilateral Craniectomy for Traumatic Acute Epidural Hemato NCT04261673 | RenJi Hospital | N/A |
| Active Not Recruiting | MiDura-Study (Neuro-Patch in Duraplasty) NCT04189172 | Aesculap AG | — |
| Completed | The Effect of Different Ventilation Strategies on Cerebral Oxygenation Using Near Infrared Spectroscopy (NIRS) NCT04232059 | Kasr El Aini Hospital | N/A |
| Unknown | Scalp Block in Elective Craniotomy for Tumor Dissection Trial NCT03776617 | George Papanicolaou Hospital | N/A |
| Unknown | Magnesium Sulphate Versus Lidocaine for Control of Emergence Hypertension NCT03566329 | Ahmed Mohamed ELbadawy | Phase 1 |
| Completed | Intraoperative Goal Directed Fluid Management in Supratentorial Brain Tumor Craniotomy NCT03033706 | Cairo University | N/A |
| Unknown | Efficacy of Scalp Block on Hemodynamic Stability and Opioid Consumption During Craniotomy NCT02880566 | University of Liege | N/A |
| Completed | Assessment of the Performance of LYoplant® ONlay for Duraplasty NCT02678156 | Aesculap AG | — |
| Completed | Treatment of Unruptured Intracranial Aneurysms in China NCT03133598 | Zhujiang Hospital | — |
| Completed | Sitting Versus Horizontal Position on Craniotomies NCT03364283 | Ohio State University | — |
| Unknown | Rapid Intravenous Infusion of Mannitol Results in a Dipper-type Change in Stroke Volume Variation in Patients NCT02237716 | First Affiliated Hospital, Sun Yat-Sen University | — |
| Unknown | Comparison of Stroke Volume Variation-guided Normovolemic and Restrictive Fluid Management During Craniotomy: NCT02113358 | National Taiwan University Hospital | N/A |
| Unknown | Blood Glucose Concentration & Craniotomy NCT01923571 | University of Roma La Sapienza | — |
| Completed | Agitation in Post Operative Neurosurgical Patients NCT00590499 | Capital Medical University | — |
| Completed | Comparison of Epinephrine-lidocaine Solution and Dexmedetomidine -Lidocaine Solution NCT01606969 | Yonsei University | N/A |
| Unknown | Influences of Types of Skull Surgery on Temporomandibular Joint Performance NCT01966939 | National Taiwan University Hospital | — |
| Completed | The Efficacy of Intravenous Acetaminophen During Perioperative Neurosurgery Period NCT01739699 | Endeavor Health | Phase 4 |
| Completed | The Efficacy of P6 Acupressure in Reducing Postoperative Nausea and Vomiting in Patients Undergoing Craniotomy NCT01617837 | Umeå University | Phase 2 / Phase 3 |
| Unknown | Intravenous Acetaminophen for Craniotomy Patients NCT01474304 | Swedish Medical Center | Phase 2 |
| Completed | eCRANIO Trial Study on Elective CRAniotomies: Postoperative Neurointensive Care, Imaging and Outcome NCT01987648 | Insel Gruppe AG, University Hospital Bern | — |
| Withdrawn | Case Series to Evaluate Patient Specific Implants (PSI) in Polyether Ether Ketone (PEEK) Performance After 2 Y NCT01282645 | Synthes GmbH | — |
| Completed | A Comparative Study of Global 12 Lead Electroencephalogram to Frontal SedlineTM Electroencephalogram NCT01256749 | Loma Linda University | — |
| Completed | Pain Prevalence After Major Craniotomy NCT01502540 | Mahidol University | — |
| Completed | Control of Emergence Blood Pressure During Craniotomy for Tumor Surgery Between Labetolol and Diltiazem NCT01408524 | Mahidol University | Phase 1 / Phase 2 |
| Completed | Craniofacial Surgery Perioperative Registry NCT00658242 | Children's Hospital of Philadelphia | — |
| Completed | Anesthesiological Strategies in Elective Craniotomy NCT00741351 | Azienda Ospedaliera San Gerardo di Monza | Phase 3 |