NCT01408524

Control of Emergence Blood Pressure During Craniotomy for Tumor Surgery Between Labetolol and Diltiazem

A Comparative Study in the Control of Emergence Blood Pressure During Craniotomy for Tumor Surgery Between Labetolol (Avexa) and Diltiazem

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 184 (actual)
• Sponsor: Mahidol University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the effectiveness of the antihypertensive drugs in the control of emergence blood pressure after tumor resection craniotomy; compared between labetalol (Avexa) and diltiazem (Herbessor). Also the investigators seek to determine the effective dose of the antihypertensive drugs and their side effects in Thai population.

Detailed description

The study was randomized equivalence trial

Conditions

• Hypertension
• Craniotomy

Interventions

Type	Name	Description
DRUG	Diltiazem	2.5 mg iv q 2-5 min for keeping SBP below 140 mmHg during the emergence
DRUG	Labetalol	2.5 mg iv q 2-5 min for keeping SBP below 140 mmHg during the emergence

Timeline

• Start date: 2010-02-01
• Primary completion: 2012-11-01
• Completion: 2013-12-01
• First posted: 2011-08-03
• Last updated: 2014-04-01