NCT03566329

Magnesium Sulphate Versus Lidocaine for Control of Emergence Hypertension

Control of Emergence Hypertension After Craniotomy: Comparison Between the Efficacy of Magnesium Sulphate and Lidocaine Infusion (Randomized Controlled Study)

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Ahmed Mohamed ELbadawy · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Post-craniotomy emergence hypertension is a common phenomenon that may predispose to development of intracranial hematoma and cerebral edema.The aim of this study is to compare the safety and efficacy of Mgso4 versus lidocaine infusion for control of emergence hypertension after craniotomy.

Conditions

• Craniotomy
• Hypertension

Interventions

Type	Name	Description
DRUG	Magnesium sulphate	Magnesium sulphate 50 mg/kg over 10 minutes loading followed by 15mg/kg/hr infusion. .
DRUG	Lidocaine Hydrochloride	lidocaine hydrochloride 1.5mg/kg loading followed by 2mg/kg/hr infusion
DRUG	Normal saline	Normal saline infusion with the same rate of infusion as the study drugs

Timeline

• Start date: 2018-07-10
• Primary completion: 2019-12-01
• Completion: 2019-12-01
• First posted: 2018-06-25
• Last updated: 2019-08-15

Locations

1 site across 1 country: Egypt