NCT04285359

Impact of Severe Intraoperative Hyperglycemia on Infection Rate After Elective Intracranial Interventions

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 514 (actual)
• Sponsor: Burdenko Neurosurgery Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Severe intraoperative hyperglycemia (SIH) is recognized as one of the important risk factors for the increasing of the postoperative infections rate, which can negatively affect the final outcome of surgical treatment. Studies in recent years have shown a much higher incidence of wound infections, respiratory and urinary tract infections in patients who intraoperatively had an increase in blood glucose level (BGL) above 180 mg/dl (10 mmol/l). This problem in neurosurgery is especially important due to the high proportion of patients with acute injuries and potentially long-term need for postoperative intensive care, as well as the frequent use of drugs that increase blood glucose level (steroids) in neurooncology. Most published studies include patients from both of these groups. This study is aimed to assess the impact of severe intraoperative hyperglycemia on the incidence of infectious complications only in patients scheduled for elective intracranial interventions.

Conditions

• Hyperglycemia
• Craniotomy
• Infection Post Op

Interventions

Type	Name	Description
PROCEDURE	Intracranial Interventions	Neurosurgical elective intracranial interventions: supra- and infratentorial craniotomies, transnasal endoscopic interventions.

Timeline

• Start date: 2020-10-28
• Primary completion: 2021-03-15
• Completion: 2021-04-01
• First posted: 2020-02-26
• Last updated: 2021-04-30

Locations

2 sites across 2 countries: Italy, Russia