NCT05582824

Lactate Metabolism in the Hypoperfused Critically Ill

Lactate Metabolism in Patientens With Hyperlactatemia-associated Metabolic Acidosis

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: University of Copenhagen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Investigating lactate metabolism in critically ill patients whom are hypoperfused by preforming metabolomics via liquid chromatography-mass spectrometry.

Detailed description

Lactate concentration is well known to be directly correlated with risk of death during admission to intensive care. However, lactate by itself is not considered toxic. The study is observational. The breakdown of lactate is being investigated by collecting blood- and urinsamples from patients with hyperlactatemia as a result of hypoperfusion. Levels of lactate, and known as well as unknown metabolites will be identified and quantified by metabolomics. Metabolomics is performed using a combination of liquid chromatography and mass spectrometry. Data will be analysed via statistical analysis to investigate corelations between lactate, a given metabolite and hard outcome such as mortality. And thereby lay the groundwork for potential further research regarding specific lactate-metabolites.

Conditions

• Lactate
• Metabolism
• Hypoperfusion
• Metabolomics
• Metabolic Acidosis

Interventions

Type	Name	Description
OTHER	Blood and urine test	Daily blood and urine samples

Timeline

• Start date: 2022-09-15
• Primary completion: 2022-11-01
• Completion: 2023-01-01
• First posted: 2022-10-17
• Last updated: 2022-10-17

Locations

1 site across 1 country: Denmark