Trials / Conditions / Apical Periodontitis

Apical Periodontitis

127 registered clinical trials studyying Apical Periodontitis — 26 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment NCT07469150	University of Alabama at Birmingham	N/A
Not Yet Recruiting	Nanozymes in Endodontics NCT07518901	University of Pennsylvania	Phase 4
Not Yet Recruiting	Biomarkers in Apical Periodontitis NCT07504861	Kırıkkale University	—
Not Yet Recruiting	Endodontic Microsurgery NCT06776289	Mark Schachman	Phase 4
Not Yet Recruiting	The Present Study Aims to Follow up on All Root Canal Treatments Performed During the Year 2023 Within the Pub NCT07244250	Region Jönköping County	—
Not Yet Recruiting	Antibacterial Activity of Calcium Hydroxide and Betamethasone in Apical Periodontitis NCT07351682	Duygu Degirmencioglu	—
Not Yet Recruiting	Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as NCT07289971	University of Health Sciences Lahore	Phase 3
Active Not Recruiting	N-acetylcysteine for Root Canal Treatment of Necrotic Teeth With Apical Periodontitis NCT07262554	Alexandria University	Phase 2
Recruiting	Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France NCT07297836	University Hospital, Strasbourg, France	—
Not Yet Recruiting	To Evaluate Periapical Healing Post Full Pulpotomy in Teeth With and Without Apical Periodontitis NCT07179835	Postgraduate Institute of Dental Sciences Rohtak	N/A
Recruiting	The Effect of Different Intracanal Medicaments on Periapical Lesion Healing NCT07237620	Mustafa Kemal University	N/A
Completed	Effect of Integrated Apex Locator Motor Modes on Postoperative Pain in Endodontic Retreatment NCT07527897	Recep Tayyip Erdogan University	N/A
Completed	Post-operative Pain After Different Irrigation and Disinfection Methods in Single-rooted Teeth NCT07170098	Biruni University	N/A
Not Yet Recruiting	Effect of Bio-C Temp Versus Calcium Ydroxide as Intracanal Dressings on Postoperative Pain Intensity and Peria NCT07101029	Cairo University	EARLY_Phase 1
Not Yet Recruiting	A Comparative Evaluation of the Degree of Pain and MMP-9 Expression Following Instrumentation of Necrotic Pulp NCT07101003	Marwa Hisham Mohamed Salah Eldin	N/A
Active Not Recruiting	Evaluation of Postoperative Pain and Lesion Healing in Periapical Lesion-Affected Teeth Obturated With Differe NCT07307807	Ankara Yildirim Beyazıt University	N/A
Recruiting	Bite Force Measurements NCT06843525	Rutgers, The State University of New Jersey	—
Recruiting	Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial) NCT07048028	ESRA DAĞCI	N/A
Recruiting	Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment NCT07448571	Marmara University	N/A
Not Yet Recruiting	To Measure Post Operative Pain Severity by Using Two Different Intra Canal Medicaments Calcium Hydroxide and T NCT06821763	Komal Ashraf Khan	Phase 2 / Phase 3
Enrolling By Invitation	Antibacterial Efficacy and Outcomes of Root Canal Irrigation Methods NCT06959602	National and Kapodistrian University of Athens	N/A
Not Yet Recruiting	Comparative Evaluation of Antimicrobial Efficacy, Clinical and Radiographic Success of Calcium Hydroxide, Chlo NCT06625645	Mahy Abdel Raouf Aly Kamar	N/A
Completed	Effect of I-PRF Application on ALP and MMP-9 Levels in Teeth With Apical Periodontitis NCT07320898	Kırıkkale University	—
Not Yet Recruiting	The Effect of Human Umbilical Cord Mesenchymal Stem Cells and Exosomes on the Healing of Postoperative Pain an NCT06764004	TC Erciyes University	Phase 1 / Phase 2
Not Yet Recruiting	Accuracy of PoCT to ELISA by Detecting Human IL-6 in Teeth with Apical Periodontitis NCT06701266	Manipal University College Malaysia	—
Completed	Success of Pulpotomy in Molars With Pulpitis With Periodontitis Detected Using AI and Those Without Periodonti NCT06767371	Misr International University	N/A
Completed	Photodynamic Therapy in Root Canal Treatment of T2DM Patients: Microbiome Analysis Via Next-Gen Sequencing NCT06931678	Saglik Bilimleri Universitesi	N/A
Active Not Recruiting	Effect of Ozone Use in Intracanal Irrigation on Oxidative Stress Level in Teeth With Asymptomatic Apical Perio NCT07171762	KEZBAN MELTEM ÇOLAK	N/A
Recruiting	Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurg NCT06574152	The University of Texas Health Science Center, Houston	N/A
Recruiting	Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L- NCT06545084	University of Pennsylvania	—
Active Not Recruiting	The Success of Root Canal Treatments Performed Using Two Different Intracanal Medicaments NCT07210177	Ege University	N/A
Not Yet Recruiting	No Code Artificial Intelligence to Detect Radiographic Features Associated With Unsatisfactory Endodontic Trea NCT06450938	University of Copenhagen	N/A
Completed	Apical Preparation Size in Regenerative Endodontics of Mature Teeth NCT07466433	Marmara University	N/A
Unknown	Clinical and Radiographic Success of Regeneration Using Injectable Platelet Rich Fibrin NCT06086249	Cairo University	N/A
Completed	Periapical Bleeding Versus PRF Techniques in Regenerative Endodontic Therapy: A Randomized Controlled Trial NCT06886438	Saglik Bilimleri Universitesi	N/A
Completed	Examination of the Effect of Nd:YAG Laser on Oxidative Stress and Matrix Metalloproteinase-9 in Teeth With Api NCT07243353	Kırıkkale University	—
Active Not Recruiting	Effectiveness of Laser-activated Photoacoustic Flow in One-visit Revision of Teeth With Apical Periodontitis NCT07387809	University of Zagreb	N/A
Completed	CGF-Enhanced Autologous Pulp Transplantation in Mature Necrotic Teeth NCT07314866	Kahramanmaras Sutcu Imam University	N/A
Completed	Lesion Healing After Regenerative Endodontic Treatment NCT06843850	TC Erciyes University	N/A
Completed	Sealers in Chronic Apical Lesions NCT07339579	Kahramanmaras Sutcu Imam University	N/A
Active Not Recruiting	Clinical Investigation of Chemomechanical Parameters for an Efficient Disinfection of the Root Canal NCT06949176	National and Kapodistrian University of Athens	N/A
Completed	Evaluation of Different Root Canal Irrigation Techniques NCT07106320	Medipol University	N/A
Completed	Evaluation of Different Root Canal Obturation Techniques NCT07106307	Medipol University	N/A
Unknown	A Study to Compare Various Root Canal Cleaning Devices Based on Cavitation,Ultrasonic and Conventional Methods NCT06005545	Lumendo AG	N/A
Recruiting	Revitalization of Traumatized Immature Permanent Teeth NCT06043453	Universitaire Ziekenhuizen KU Leuven	—
Completed	Comparison of Post-operative Pain After Use of Endo-activator and Conventional Irrigation During Endodontic Tr NCT06668662	Jinnah Sindh Medical University	N/A
Completed	The Efficacy of Two Different Irrigation Methods on PGE2, NO and IL-6 Levels NCT06629545	Istanbul Medipol University Hospital	N/A
Completed	Sclerostin Regulation in Apical Periodontitis Lesions in Apical Periodontitis Lesions NCT06512103	Istanbul Medipol University Hospital	—
Completed	Effect of Use of Calcium Hydroxide and Metformin Intracanal Medicament After NSRCT NCT06766201	Postgraduate Institute of Dental Sciences Rohtak	Phase 2 / Phase 3
Active Not Recruiting	Periapical Healing in Response to Endodontically Treated Teeth With Different Sealing Cement NCT06482593	Institucion Universitaria Colegios de Colombia	Phase 4
Unknown	Effects of RCT on Periapical Healing, Inflammatory Markers, and Kidney Function Indicators in CKD Patients Wit NCT06446011	Postgraduate Institute of Dental Sciences Rohtak	N/A
Unknown	2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament NCT03700788	University of Southern California	Phase 3
Unknown	Outcome of Regenerative Endodontic Procedure and Root Canal Treatment for the Management of Apical Periodontit NCT06179433	Postgraduate Institute of Dental Sciences Rohtak	N/A
Unknown	Association of Apical Periodontitis With Systemic Level of Inflammatory Markers : A Longitudinal Intervention NCT05814965	Postgraduate Institute of Dental Sciences Rohtak	N/A
Completed	Can Instrumentation Kinematics Affect Post Operative Pain and Substance P Levels? A Randomized Controlled Tria NCT06081335	Ain Shams University	N/A
Completed	The Effect of Using Octenidine Hydrochloride as a Final Irrigation Solution on Teeth With Asymptomatic Apical NCT07173725	Bezmialem Vakif University	N/A
Completed	Comparison of Sonic and Ultrasonic Activation on Healing of Apical Periodontitis NCT07249450	Hilal Çuhadar Beşiroğlu	N/A
Unknown	Evaluation of Nano Bioactive Glass Combined With i-PRF Scaffold in Vital Pulp Treatments NCT05902936	Cairo University	N/A
Completed	Influence of Sonic Activation of Root Sealers on Post-Operative Pain NCT06403293	Mustafa Kemal University	N/A
Unknown	Effect of Diclofenac Sodium Versus Calcium Hydroxide as Intracanal Medication on the Intensity of Postoperativ NCT05582421	Cairo University	EARLY_Phase 1
Unknown	hsCRP & CH Indices in Patients With Coronary Artery Disease With and Without Apical Periodontitis NCT06270693	Postgraduate Institute of Dental Sciences Rohtak	N/A
Completed	Association Between Apical Periodontitis and Atherosclerotic Cardiovascular Diseases NCT05792787	University of Siena	—
Unknown	Application of a Dental-dedicated MRI in the Diagnosis of Temporomandibular Joint Disorders, Tissue Alteration NCT05439330	University of Aarhus	N/A
Completed	Effects of Intracanal Cryotherapy on Endodontic Postoperative Pain NCT05611736	Qassim University	N/A
Completed	Apical Periodontitis and Mental Health NCT06589076	University of Siena	—
Completed	Expression of IL-8 Before and After Root Canal Treatment in Patients With Symptomatic Apical Periodontitis NCT05653947	Cairo University	N/A
Completed	Evaluation of the Effect of Leukocyte and Platelet-rich Fibrin on Healing After Periradicular Surgery NCT05847647	Seyda Ersahan, DDS, PhD	N/A
Completed	Association Between Apical Periodontitis and Psoriasis Vulgaris NCT06436339	University of Siena	—
Unknown	Evaluation of IL-17, TNF-alpha, RANKL Levels in Gingival Cervicular Fluid NCT05232591	Yuzuncu Yil University	—
Completed	Efficacy of Lasers in Root Canal Treatment, Part II: Postoperative Pain NCT06129643	Future University in Egypt	Phase 2
Completed	Comparing Different Single and Combination Chelating Agents on Sealer Penetration and Dentin Erosion. NCT05778227	Dow University of Health Sciences	N/A
Completed	Effectiveness of Different Obturation Techniques NCT06226740	Abant Izzet Baysal University	N/A
Terminated	Effectiveness of GentleWave on the Healing of Apical Periodontitis: A Prospective Cohort Study NCT04966169	University of Iowa	N/A
Completed	Intraoral Cryotherapy on Cytokine Levels and Postoperative Endodontic Pain NCT05017064	Ondokuz Mayıs University	N/A
Completed	Regenerative Endodontic Treatment of Mature Necrotic Teeth With Apical Periodontitis NCT04018456	Cairo University	N/A
Completed	Effect of Smoking on Periapical Healing After NSRCT NCT05799937	Postgraduate Institute of Dental Sciences Rohtak	—
Completed	Assessment of Different Disinfection Protocols on Regenerative Potential of Mature Teeth NCT05557994	Minia University	N/A
Completed	Serum Pro-Diabetes Inflammation Biomarkers in Patients With Apical Periodontitis. NCT04824209	University of Turin, Italy	—
Completed	Inflammation-Related Endothelial Barrier Dysfunction in Patients With Apical Periodontitis NCT07292363	University of Turin, Italy	—
Completed	Comparative Analysis of Photodynamic Therapy on Periapical Healing NCT06553144	University of Gaziantep	N/A
Unknown	Effect of Low-level Laser Therapy Versus Calcium Hydroxide Intracanal Medication on Postoperative Pain and Sub NCT04594317	Cairo University	N/A
Unknown	Prospective Endodontics Database NCT04716478	Hospices Civils de Lyon	—
Completed	Healing Outcomes Following Hydraulic Condensation With a Bioactive Bioceramic Sealer in Root Canal Treatment NCT07075354	Plovdiv Medical University	N/A
Completed	The Effect of Different Irrigation and Disinfection Methods on Post-operative Pain (PP) NCT05195021	Biruni University	N/A
Recruiting	One Vs Two Visits Root Canal Treatments in Infected Teeth NCT04605445	Malmö University	N/A
Completed	Cryotherapy on Inflammatory Profile and Postoperative Pain Levels in Endodontic Infections NCT04798144	Ondokuz Mayıs University	N/A
Completed	Postoperative Pain and Healing in Teeth Treated With GentleWave or EndoActivator NCT04552132	St. Louis University	N/A
Completed	Effect of Lifestyle on Caries and Apical Periodontitis NCT06072742	University of Siena	—
Withdrawn	Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - General NCT04104789	Virginia Commonwealth University	Phase 2
Unknown	Endodontic Microsurgery With the Use of L-PRF Block NCT05379010	Universitaire Ziekenhuizen KU Leuven	N/A
Withdrawn	Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Endodontics NCT04105985	Virginia Commonwealth University	Phase 2
Completed	A New Clinical Use of Ferumoxytol Nanoparticles: An Antibiofilm Treatment NCT06110494	University of Pennsylvania	Phase 4
Completed	"Effect of Apical Patency on Post-endodontic Pain" NCT04551209	National University of Medical Sciences, Pakistan	N/A
Completed	Postoperative Pain After Using NiTi Instruments NCT04700995	Trakya University	N/A
Completed	Ethanolic Extract of Sapindus Mukorrossi as Final Endodontic Irrigant. NCT05038059	Dow University of Health Sciences	N/A
Unknown	Single And Multiple-visit Endodontic Retreatment Outcome. NCT04390789	Postgraduate Institute of Dental Sciences Rohtak	N/A
Completed	Transplantation of Allogeneic MSC in Patients With Pulp Necrosis and Chronic Apical Periodontitis NCT04545307	Universidad Central de Venezuela	Phase 2 / Phase 3
Unknown	Assessment of Regenerative Potential of Mature Permanent Teeth With Necrotic Pulps Using Two Revascularization NCT04158232	Minia University	N/A
Completed	Effects of PDT and Bioceramic Filling on Periapical Healing and Postoperative Pain After Endodontic Retreatmen NCT04072926	Medical Innovation Center Wroclaw	EARLY_Phase 1
Completed	Therapeutic Irrigation Procedures to Treat Apical Periodontitis NCT03987659	University of Birmingham	N/A
Completed	Bone Regenerative Techniques in Endodontic Microsurgery NCT04514991	University of Pennsylvania	N/A
Terminated	Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Pediatric NCT03962634	Virginia Commonwealth University	Phase 2
Completed	E. Faecalis Prevalence in Primary and Secondary Endodontic Infections: a Pre-post Microbial Analysis Following NCT04637659	University of Siena	—
Completed	Effect of Diode Laser on Post-operative Pain After Endodontic Treatment in Teeth With Apical Periodontitis NCT04486196	Biruni University	N/A
Completed	Effect of Primary Non-surgical Endodontic Therapy on Glycaemic Control in Type 2 Diabetic Patients With Asympt NCT05170880	Postgraduate Institute of Dental Sciences Rohtak	N/A
Unknown	In Vivo Assessment of Endodontics Procedures NCT03243357	Federal University of Uberlandia	N/A
Unknown	FE in Anterior Teeth NCT03527602	Isparta Military Hospital	N/A
Unknown	Effect of Occlusal Reduction on Post-operative Pain NCT03189771	Cairo University	N/A
Completed	Postoperative Pain and PTN and Reciproc NCT03380585	Isparta Military Hospital	N/A
Unknown	Effect of Passive Ultrasonic Irrigation Versus Needle Irrigation on Postoperative Pain and Periapical Healing NCT02913937	Cairo University	N/A
Completed	Reciprocation vs Rotational Single-file Systems in Postoperative Pain NCT02929511	Isparta Military Hospital	N/A
Completed	The Effect of MTA and PRF Application in Periapical Lesions NCT03743987	Recep Tayyip Erdogan University Training and Research Hospital	N/A
Completed	Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment NCT03288467	Postgraduate Institute of Dental Sciences Rohtak	N/A
Unknown	Association of Endodontic Infection With Cardiovascular Disease. NCT03425383	Postgraduate Institute of Dental Sciences Rohtak	—
Completed	Effect of Various Sealers on Healing of Teeth With Apical Periodontitis NCT03397875	Postgraduate Institute of Dental Sciences Rohtak	N/A
Completed	Comparison of Healing of Apical Periodontitis in Periodontally Diseased and Healthy Patients. NCT03711942	Postgraduate Institute of Dental Sciences Rohtak	N/A
Completed	Effect of Intraorifice Barrier on Healing of Apical Periodontitis NCT03409887	Postgraduate Institute of Dental Sciences Rohtak	N/A
Completed	Effect of Coronal Extent of Obturation on Endo-perio Lesions NCT03171376	Postgraduate Institute of Dental Sciences Rohtak	N/A
Unknown	Outcome of Endodontic Treatment in Patient Treated With a Hydraulic Sealer NCT04249206	Cittadella Universitaria	Phase 4
Completed	Validation of PUFA Index in Assessing Untreated Dental Caries Among Malaysian Adult Subpopulation NCT04126928	Universiti Kebangsaan Malaysia Medical Centre	N/A
Completed	Effect of Smear Layer on Endodontic Outcome NCT03277404	Postgraduate Institute of Dental Sciences Rohtak	N/A
Completed	Effect of Different Instrumentation Technique on Endodontic Outcome NCT03278054	Postgraduate Institute of Dental Sciences Rohtak	N/A
Completed	Clinical and Microbiological Evaluation of 0.5% Versus 3% Sodium Hypochlorite in Root Canal Treatment NCT02681276	Göteborg University	N/A
Completed	Evaluation of iRoot SP as Root Canal Sealer: A Clinical Study NCT02981693	Hui Chen	N/A
Completed	Effect of Apical Patency on Success of Root Canal Treatment in Non Vital Teeth NCT03454815	Postgraduate Institute of Dental Sciences Rohtak	N/A
Completed	Accuracy of ERCLMDs in Teeth With Apical Periodontitis NCT01904552	Isfahan University of Medical Sciences	Phase 1
Recruiting	Factors Affecting the Endodontic Treatment Outcome NCT05221450	Odontos, Specialisticna Zobna Ambulanta, d.o.o.	—