NCT06482593

Periapical Healing in Response to Endodontically Treated Teeth With Different Sealing Cement

Periapical Healing in Response to Endodontically Treated Teeth With Different Sealing Cements: An in Vivo Study With CBCT

• Status: Active Not Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 72 (actual)
• Sponsor: Institucion Universitaria Colegios de Colombia · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to conduct an in vivo study that allows to compare the periapical healing process of 3 different sealing cements through CBCT, as well as implement the evaluation of these lesions through volumetric measurements to provide high-level scientific information and thus have the possibility of being applied in the clinical dental practice, in patients attending UNICOC dental clinics between 2023 and 2024. The main question it aims to answer is: * Do bioceramic sealer promote faster periapical healing due to their better sealing capacity and high bio-compatibility? * Are there no differences between endodontic sealers in terms of apical healing? If there is a comparison group: Researchers will compare Bio-C Sealer (Bioceramic sealer) Zinc-oxide eugenol sealer and AH-Plus epoxy resin sealer to evaluate periapical healing after a six months follow-up of conventional endodontic therapy. Coronal permanent restoration must be performed no later than 15 days after endodontic therapy.

Conditions

• Apical Periodontitis

Interventions

Type	Name	Description
DRUG	Zinc-Oxide Eugenol Sealer	Zinc oxide-eugenol sealers have a slow setting time, shrinkage while setting, solubility, and can discolour tooth structure. This sealer group has an advantage in terms of antibacterial activity.It will absorb if extruded into the periradicular tissues.
DRUG	AH-Plus Epoxy Resin Sealer	Dentsply AH Plus Root Canal Sealing Material is a two-component paste/paste root canal sealer based on epoxy-amine resin. The AH Plus sealer shows extremely low shrinkage making it a suitable choice of material to seal the root canal.
DRUG	Bio-C Sealer	Bio-C® Sealer is a ready-to-use, bioceramic root canal sealer with biologically active ingredients to seal and heal the root canal space. Bio-C Sealer's mechanical and physical properties make it easy to manipulate and seal the canals, while its biological properties and high pH ensure safety and treatment success.

Timeline

• Start date: 2023-08-01
• Primary completion: 2024-03-31
• Completion: 2024-09-30
• First posted: 2024-07-01
• Last updated: 2024-07-09

Locations

1 site across 1 country: Colombia

Regulatory

• FDA-regulated drug study