Trials / Active Not Recruiting
Active Not RecruitingNCT07262554
N-acetylcysteine for Root Canal Treatment of Necrotic Teeth With Apical Periodontitis
Evaluation of N-acetylcysteine as an Intracanal and Adjunctive Systemic Medication in Root Canal Treatment of Necrotic Mature Teeth With Apical Periodontitis: a Randomized Controlled Clinical Trial
- Status
- Active Not Recruiting
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- Sponsor
- Alexandria University · Academic / Other
- Sex
- All
- Age
- 16 Years – 60 Years
- Healthy volunteers
- Not accepted
Summary
A randomized controlled trial comparing the postoperative pain intensity, periapical biomarkers level, and periapical healing in patients with necrotic mature teeth and apical periodontitis treated with N-acetylcysteine (NAC), as an intracanal and adjunctive systemic medication, versus calcium hydroxide (Ca(OH)₂) intracanal medication alone.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Calcium hydroxide (Ca(OH)₂) | UltraCal XS calcium hydroxide (Ca(OH)₂) intracanal medication for 7 days |
| DRUG | N-Acetylcysteine (NAC) | N-acetylcysteine (NAC) intracanal medication for 7 days and 600 mg/day oral NAC for 21 days |
Timeline
- Start date
- 2025-11-15
- Primary completion
- 2026-06-01
- Completion
- 2026-06-01
- First posted
- 2025-12-03
- Last updated
- 2025-12-30
Locations
1 site across 1 country: Egypt
Source: ClinicalTrials.gov record NCT07262554. Inclusion in this directory is not an endorsement.