NCT06701266

Accuracy of PoCT to ELISA by Detecting Human IL-6 in Teeth with Apical Periodontitis

Diagnostic Agreement of Human Interleukin-6 Chairside Point-of-Care Test (PoCT) to Enzyme-Linked Immunosorbent Assay (ELISA) in Teeth with Apical Periodontitis

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Manipal University College Malaysia · Academic / Other
• Sex: All
• Age: 17 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

To compare the diagnostic agreement of human IL-6 chairside PoCT to ELISA in apical periodontitis undergoing endodontic therapy which could be clinically helpful to monitor the healing of periapical tissues enabling the clinician to complete the endodontic procedure, leading to a better patient care. This study will be conducted at the Conservative and Endodontics Department in Polyclinic B, Faculty of Dentistry, Manipal University College Malaysia (MUCM). It involves 30 selected patients who have single rooted tooth with apical periodontitis that undergo RCT. The collection of the exudate from the canal will be on pre and post-instrumentation. The exudated will collect twice in each instrumentation for PoCT and ELISA.

Conditions

• Apical Periodontitis

Interventions

Type	Name	Description
DEVICE	Point of Care Test	PoCT as a chairside test, ELISA as a gold standard

Timeline

• Start date: 2024-12-01
• Primary completion: 2025-06-01
• Completion: 2025-11-01
• First posted: 2024-11-22
• Last updated: 2024-11-22

Locations

1 site across 1 country: Malaysia