NCT06081335

Can Instrumentation Kinematics Affect Post Operative Pain and Substance P Levels? A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 20 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The aim of this study was to evaluate the effect of continuous rotation and reciprocation kinematics on post operative pain and difference in substance P levels in patients with irreversible pulpitis with symptomatic apical periodontitis. Twenty patients were randomly distributed into two groups; Continuous Rotation group(n=10): received mechanical preparation using EdgeEndo x7 rotary system (Albuquerque, New Mexico, USA), while Reciprocation group(n=10): received mechanical preparation using EdgeOne Fire reciprocating system (Albuquerque, New Mexico, USA). Apical fluid(AF) samples were collected, and substance P (SP) levels were measured using radioimmunoassay and postoperative pain was measured using Numerical Rating Scale (NRS) preoperatively, at 6h, 12h, 24h, 48h and 72h.

Conditions

• Pain, Postoperative
• Irreversible Pulpitis
• Apical Periodontitis

Interventions

Type	Name	Description
DEVICE	EdgeEndo x7 continuous rotation files	endodontic files operating in continuous rotation
DEVICE	EdgeOne Fire reciprocating files	endodontic files operating in reciprocating motion

Timeline

• Start date: 2023-03-15
• Primary completion: 2023-04-05
• Completion: 2023-06-05
• First posted: 2023-10-13
• Last updated: 2023-11-15

Locations

2 sites across 1 country: Egypt