| Not Yet Recruiting | Comparative Effectiveness in the Management of Irreversible Pulpitis NCT04922229 | University of Alabama at Birmingham | N/A |
| Not Yet Recruiting | Postoperative Pain After Pulpectomy in Primary Molars NCT07427420 | Cairo University | N/A |
| Not Yet Recruiting | Evaluation of Bacterial Reduction After Pulpectomy in Primary Molars NCT07472751 | Cairo University | N/A |
| Not Yet Recruiting | To Evaluate Post Operative Pain Using Two Different Kind of Sealers in Obturation of Teeth With Symptomatic Ir NCT07266974 | Jaweria Gul Keyani | Phase 2 / Phase 3 |
| Not Yet Recruiting | Child's Behavior Using Single Rotary File System Versus Manual Instrumentation in Pulpectomy of Primary Molars NCT07415694 | Cairo University | N/A |
| Not Yet Recruiting | Comparison of Treatment Outcome of Pulpotomy With Versus Without Dental Operating Microscope in Carious Mature NCT07388862 | Chulalongkorn University | EARLY_Phase 1 |
| Not Yet Recruiting | Clinical and Radiographic Outcomes of Rotary Instrumentation in Primary Molars NCT07319741 | Anfal mohamed elmotaz almogtaba | N/A |
| Not Yet Recruiting | Effect of Cryotherapy on Anesthetic Success and Pain in Irreversible Pulpitis NCT07403578 | TC Erciyes University | N/A |
| Not Yet Recruiting | CGF Partial Pulpotomy Versus Endodontic Treatment NCT07417098 | Minia University | N/A |
| Active Not Recruiting | Comparison of Pain Between Supraperiosteal Injection of Dexamethasone Versus Placebo on Postoperative Pain in NCT07233564 | College of Physicians and Surgeons Pakistan | N/A |
| Not Yet Recruiting | Treatment Outcomes of Pulpotomy Versus Pulpectomy in Vital Primary Molars Diagnosed With Irreversible Pulpitis NCT06904781 | Qatar University | N/A |
| Not Yet Recruiting | Comparison of 3Mixtatin Pulpotomy and Metapex Pulpectomy in Primary Molars With Irreversible Pulpitis NCT06925490 | Cairo University | Phase 1 |
| Recruiting | Bite Force Measurements NCT06843525 | Rutgers, The State University of New Jersey | — |
| Not Yet Recruiting | To COMPARE the EFFECT of TWO INSTRUMENTATION TECHNIQUES on the INCIDENCE of POST-ENDODONTIC PAIN in PATIENTS U NCT06842251 | Urooj Fatima | N/A |
| Recruiting | Complete Pulpotomy and Root Canal Treatment Patients With Irreversible Pulpitis With Type 2 Diabetes Mellitus NCT07163975 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Not Yet Recruiting | Post Operative Pain Following Pulpectomy Versus Pulpotomy in Primary Molars Wit Irreversible Pulpitis NCT06903013 | Minia University | N/A |
| Active Not Recruiting | Evaluation of Pulpal Biomarkers in Vital Pulp Therapy NCT07073573 | ertuğrul karataş | N/A |
| Not Yet Recruiting | Clinical and Radiographic Evaluation of Calcium Hypochlorite Versus Saline As Root Canal Irrigants in Pulpecto NCT06748781 | Cairo University | N/A |
| Completed | Success of Pulpotomy in Molars With Pulpitis With Periodontitis Detected Using AI and Those Without Periodonti NCT06767371 | Misr International University | N/A |
| Active Not Recruiting | Clinical and Radiographic Evaluation of Propolis As a Hemostatic Agent for Pulpotomy of Mature Permanent Molar NCT06679075 | Misr International University | Phase 2 |
| Not Yet Recruiting | Post Operative Pain and Oral Health Related Quality of Life Following Pulpotomy VS Extraction of Permanent Fir NCT06420583 | Cairo University | N/A |
| Recruiting | Clinical and Radiographic Assessment of Photobiomodulated MTA Pulpotomy in Immature First Permanent Molars wit NCT06730360 | Mansoura University | N/A |
| Completed | Evaluation of Post Obturation Pain Associated With Calcium Hydroxide-based Root Canal Sealers and Resin-based NCT06798467 | Jinnah Sindh Medical University | N/A |
| Active Not Recruiting | In Vivo Pulp Thermal Changes During Different Slenderization Techniques NCT07391124 | Armed Forces Institute of Dentistry, Pakistan | N/A |
| Not Yet Recruiting | Full Pulpotomy Procedure of Permanent Molar Teeth of Adults Using Calcium Silicate-based Sealer Material NCT06504108 | Al-Azhar University | N/A |
| Not Yet Recruiting | Comparing MTA Pulpotomy to Root Canal Treatment in Management of Permanent Molars With Irreversible Pulpitis i NCT06488131 | Ain Shams University | Phase 4 |
| Recruiting | The Effect of Different Risk Factors on the Success Rate of VPT NCT06844448 | Semmelweis University | — |
| Not Yet Recruiting | Effectiveness of Two Intracanal Irrigation Solutions NCT06427070 | Misr University for Science and Technology | N/A |
| Completed | Outcome Following Use of Different Concentrations of NaOCl as Wound Lavage and Hemostatic Agent in Partial Pul NCT06433245 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Completed | Comparison of Endodontic Postoperative Pain Using Different Irrigation Systems NCT06358833 | Qassim University | N/A |
| Recruiting | Effectiveness of Pulpotomy in Symptomatic Permanent Teeth With Deep Caries Lesions NCT06918639 | Universidad Rey Juan Carlos | — |
| Active Not Recruiting | Pulpotomy in Vital Primary Molars Diagnosed With Symptomatic Irreversible Pulpitis NCT06149845 | Qatar University | N/A |
| Recruiting | The Influence of Magnification and Clinical Experience on the Outcome of Pulpotomy in Mature Adult Teeth NCT06231290 | Al-Azhar University | N/A |
| Unknown | Effect of Conservative Root Canal Instrumentation on the Release of Inflammatory Mediators in Root Canal Treat NCT06237985 | Saglik Bilimleri Universitesi | N/A |
| Not Yet Recruiting | Treatment Outcomes of Pulpotomy vs. Pulpectomy in Vital Primary Molars With Symptomatic Irreversible Pulpitis NCT06183203 | Nebu Philip | N/A |
| Recruiting | Evaluation of Antimicrobial, Post Operative Pain of Cinnamon Extract Versus Sodium Hypochlorite Irrigant Follo NCT05860712 | Cairo University | N/A |
| Unknown | Influence of Moment of Restoration in Pain After a Root Canal Treatment NCT06142799 | Universitat Internacional de Catalunya | N/A |
| Recruiting | Assessment of L-PRF, Nanohydroxyapatite Combined With L-PRF Using Pulpotomy in Mature Mandibular First Molars NCT06613932 | Future University in Egypt | N/A |
| Active Not Recruiting | Evaluation of Two Different Calcium Silicate Cements as a Treatment for Irreversible Pulpitis in Mature Molars NCT07066410 | British University In Egypt | N/A |
| Unknown | Efficacy of Computer Controlled Intraosseous Anesthesia in Pediatric Dental Patients NCT06245161 | Alexandria University | N/A |
| Completed | Outcome of Complete Pulpotomy in Healthy and Type 2 Diabetic Patients in Permanent Teeth with Irreversible Pul NCT06586775 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Active Not Recruiting | Epigallocatechin Gallate (EGCG) as a Flushing Agent During Full Pulpotomy in Mature Permanent Molars With Irre NCT05811403 | Cairo University | N/A |
| Completed | The Effect of Totalfil and Neosealer Sealers on the Post-endodontic Pain NCT06194773 | Gulf Medical University | N/A |
| Completed | Relationship of Eye Colour With Anesthetic Success and Post-Operative Pain NCT06206304 | Mustafa Kemal University | — |
| Completed | The Effect of Intra-pulpal Anesthesia With Cryotherapy on Intra-operative Pain NCT06194721 | Gulf Medical University | N/A |
| Completed | Evaluation of Hemostasis Time on Partial Pulpotomy in Teeth With Clinical Signs Indicative of Irreversible Pul NCT06768567 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Completed | Can Instrumentation Kinematics Affect Post Operative Pain and Substance P Levels? A Randomized Controlled Tria NCT06081335 | Ain Shams University | N/A |
| Completed | Evaluation of Using Platelet-Rich Fibrin in Adult Pulpotomy NCT06437197 | Al-Azhar University | N/A |
| Unknown | Oral Dexamethasone for the Management of Symptomatic Irreversible Pulpitis Without Performing Pulpotomy NCT05761730 | May Samaha | Phase 1 |
| Completed | Cytokines as Diagnostic Markers of Pulpal Inflammation and Their Impact on the Outcome of Vital Pulp Therapy NCT07261761 | Mansoura University | N/A |
| Completed | Comparison of Effectiveness of Pre-cooling With Ethyl Chloride Versus Honey NCT05568563 | Altamash Institute of Dental Medicine | N/A |
| Completed | Outcome Following Use of NaOCl and Chlorhexidine as Wound Lavage Agents NCT06240130 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Unknown | TheraCal LC Coronal Pulpotomy and MTA Coronal Pulpotomy in Mature Permanent Molars NCT05733468 | Postgraduate Institute of Dental Sciences Rohtak | Phase 4 |
| Completed | Simultaneous Working Length Detection Methods NCT06507982 | Istanbul Medipol University Hospital | N/A |
| Completed | Comparison of Antimicrobial Action of Sodium Hypochlorite and Polyhexamethylene Biguanide as Root Canal Irriga NCT05306431 | Altamash Institute of Dental Medicine | Phase 2 |
| Unknown | Cryotherapy Efficacy During Pulp Therapy of the Mandibular First Permanent Molars in Children NCT05441995 | Minia University | N/A |
| Completed | Clinical and Radiographic Outcomes of Pulpotomy in Teeth with Different Symptoms and Root Stages NCT06874088 | Muhammed Alagöz | N/A |
| Unknown | Analgesic Effect of Anahil and Ibuprofen on Pain After Root Canal Therapy in Patients With Pulpitis of the Mol NCT05349929 | Qazvin University Of Medical Sciences | Phase 2 |
| Unknown | Effect of Using Different Concentrations of NaOCI on IL-8 Level NCT05277246 | Yuzuncu Yil University | N/A |
| Unknown | Effectiveness of Pulpotomy in the Management of Mature Permanent Tooth With Irreversible Pulpits NCT05622266 | Nanfang Hospital, Southern Medical University | N/A |
| Completed | the Effect of Preoperative Sodium Ibuprofen on Postoperative Endodontic Pain NCT04964622 | Cairo University | Phase 1 / Phase 2 |
| Completed | Comparing Different Single and Combination Chelating Agents on Sealer Penetration and Dentin Erosion. NCT05778227 | Dow University of Health Sciences | N/A |
| Unknown | Evaluation of Trans-mucosal Bio-adhesive Discs of Diclofenac Potassium on the Anesthetic Success and Postopera NCT04585438 | Cairo University | Phase 4 |
| Unknown | Success and Quality of Life Following Complete Pulpotomy and Root Canal Treatment NCT05190406 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Unknown | Comparative Study of the Outcome of Partial and Full Pulpotomy in Irreversible Pulpits NCT05279820 | Jordan University of Science and Technology | N/A |
| Unknown | Treatment of Deep Carious Lesions With Selective Caries Removal, Partial or Full Pulpotomy NCT04807244 | Charite University, Berlin, Germany | N/A |
| Completed | Healing Outcomes Following Hydraulic Condensation With a Bioactive Bioceramic Sealer in Root Canal Treatment NCT07075354 | Plovdiv Medical University | N/A |
| Completed | Comparison of Nitrofurantoin and Calcium Hydroxide as Intracanal Medicaments in Alleviating Post-operative Pai NCT04900571 | Altamash Institute of Dental Medicine | Phase 4 |
| Completed | Patient Perception Between Two Emergency Treatments of Symptomatic Irreversible Pulpitis. NCT04654845 | Aula Dental Avanzada | N/A |
| Unknown | Comparing the Outcome of Pulpotomy Using Biodentine and Portland Cement in Mature Cases With Irreversible Pulp NCT04573374 | Cairo University | N/A |
| Completed | A Clinical and Radiographic Evaluation of Low-Level Diode Laser Full Pulpotomy in Vital Permanent Teeth NCT06176378 | Al-Azhar University | N/A |
| Completed | Ethanolic Extract of Sapindus Mukorrossi as Final Endodontic Irrigant. NCT05038059 | Dow University of Health Sciences | N/A |
| Terminated | Evaluation of Methylprednisolone or Ibuprofen on Efficacy of Nerve Blocks With Symptomatic Irreversible Pulpit NCT04157036 | Walter Reed National Military Medical Center | Phase 3 |
| Withdrawn | Residual Dental Pulp Tissue and Cord Blood Stem Cells NCT04040127 | University of California, San Francisco | Phase 2 |
| Completed | PRF Pulpotomy Using Different Bioceramic Materials in Permanent Molars NCT04784949 | Fayoum University | N/A |
| Unknown | Diode Laser Pulpotomy of Mature Permanent Molars With Irreversible Pulpitis NCT05427851 | Alexandria University | N/A |
| Unknown | MTA vs CEM Pulpotomy in Young Permanent Molars NCT04243733 | Suez Canal University | N/A |
| Unknown | Comparison of Anesthetic Efficacy of Dexmedetomidine and Epinephrine With Lidocaine in Irreversible Pulpitis NCT03415724 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Completed | Partial Pulpotomy in Mature Permanent Teeth With Signs and Symptoms of Irreversible Pulpits NCT04870398 | National and Kapodistrian University of Athens | N/A |
| Unknown | Ketorolac Premedication for Anesthetic Efficiency of IANB & Postendodontic Pain in Teeth With Irreversible Pul NCT02940405 | Cairo University | N/A |
| Completed | Premedication Efficacy of Ketorolac Infiltration on Post Endodontic Pain NCT02923687 | Azad University of Medical Sciences | Phase 2 |
| Completed | Pre-operative Aceclofenac on the Anesthetic Efficacy of IANB in Symptomatic Irreversible Pulpitis NCT03146481 | Cairo University | Phase 2 / Phase 3 |
| Unknown | Diclofenac Potassium on IANB Efficacy in Symptomatic Irreversible Pulpitis NCT03163420 | Cairo University | Phase 2 / Phase 3 |
| Unknown | Pulpotomy as a Treatment of Irreversible Pulpitis NCT02920606 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | N/A |
| Completed | Premedication Efficacy of Oral Ketorolac and Ketorolac/ Acetaminophen on Post Treatment Pain NCT02614118 | Azad University of Medical Sciences | Phase 2 |
| Completed | Effect of Premedication on Success of Inferior Alveolar Nerve Block Injection NCT02601911 | Azad University of Medical Sciences | Phase 2 |
| Completed | 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis NCT02807298 | Dr. D. Y. Patil Dental College & Hospital | Phase 3 |
| Completed | Evaluation of iRoot SP as Root Canal Sealer: A Clinical Study NCT02981693 | Hui Chen | N/A |
| Completed | Dexketoprofen Trometamol in Postoperative Endodontic Pain NCT02086097 | Daniel Chavarría Bolaños | Phase 4 |
| Unknown | Similar Outcomes of Vital Pulp Therapy Using Mineral Trioxide Aggregate or Biodentine™ NCT03186690 | Jordan University of Science and Technology | N/A |
| Unknown | A Clinical Study: the Antibacterial Effect of Insoluble Antibacterial Nanoparticles (IABN) Incorporated in Den NCT01167985 | Hadassah Medical Organization | Phase 2 |
| Completed | Effect of Addition of Mannitol to Bupivacaine on IANB Success and Post-endodontic Pain NCT03749408 | Cairo University | Phase 2 / Phase 3 |
| Completed | Efficacy of Different Drugs to Control Post Root Canal Treatment Pain NCT02417337 | University of Khartoum | Phase 2 |
| Completed | Vital Pulp Therapy (VPT) Using Calcium Enriched Mixture (CEM) to Treat Irreversible Pulpitis NCT01561183 | Shahid Beheshti University of Medical Sciences | N/A |
| Completed | Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars NCT01496846 | University of Michigan | Phase 4 |
| Completed | Anesthetic Efficacy of Articaine and Lidocaine in Lower Molars With Irreversible Pulpits NCT01912755 | University of Campinas, Brazil | Phase 4 |
| Completed | Effect of Sufentanil on the Rate of Anesthesia NCT01572116 | Islamic Azad University, Sanandaj | Phase 2 |