NCT05811403

Epigallocatechin Gallate (EGCG) as a Flushing Agent During Full Pulpotomy in Mature Permanent Molars With Irreversible Pulpitis

The Influence of Epigallocatechin Gallate (EGCG) as a Flushing Agent During Full Pulpotomy Using Two Different Calcium Silicate-based Materials on Postoperative Pain and Success Rate in Mature Permanent Molars With Irreversible Pulpitis: A Randomized Clinical Trial

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 64 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This study evaluates the effect of two flushing agents (epigallocatechin gallate (EGCG) and sodium hypochlorite (NaOCl)) during full pulpotomy using two different calcium silicate-based materials (MTA and premixed bioceramic putty) on postoperative pain, success rate and dentin bridge thickness in mature permanent mandibular molars with irreversible pulpitis. Participants will be divided into four groups based on the flushing fluid and the pulp capping material to be used.

Conditions

• Irreversible Pulpitis

Interventions

Type	Name	Description
OTHER	Epigallocatechin gallate (EGCG)	Epigallocatechin gallate (EGCG) is a white powder that can be obtained from tea leaves. It accounts for 50-60 % of catechin content of tea polyphenols with a wide range of biological activities including antioxidant, antimicrobial, anti-inflammatory, immune regulatory, anti-tumour effects.
OTHER	Sodium hypochlorite (NaOCl)	Sodium hypochlorite (NaOCl) is an excellent non-specific proteolytic and antimicrobial agent that provides disinfection of the dentin-pulp interface.
OTHER	Mineral trioxide aggregate (MTA)	Mineral trioxide aggregate (MTA) is the material of choice for pulp capping in vital pulp therapy.
OTHER	Premixed bioceramic putty	Bioceramic putty is a premixed, ready-to-use calcium silicate-based material which can be used as a pulp capping material.

Timeline

• Start date: 2023-07-01
• Primary completion: 2025-06-30
• Completion: 2026-06-30
• First posted: 2023-04-13
• Last updated: 2026-03-25

Locations

1 site across 1 country: Egypt