NCT04922229

Comparative Effectiveness in the Management of Irreversible Pulpitis

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 138 (estimated)
• Sponsor: University of Alabama at Birmingham · Academic / Other
• Sex: All
• Age: 12 Years – 99 Years
• Healthy volunteers: Accepted

Summary

This project addresses a central question within the practice of dentistry: Is a pulpotomy procedure effective in the treatment of a tooth with symptomatic irreversible pulpitis and normal periapex? In addition, the project seeks to identify clinical and molecular biomarkers that are predictive of the success of pulpotomy.

Detailed description

In this study, patients will be randomized to two groups. All patients will have a diagnosis of irreversible pulpitis with normal apical tissues. The groups will be root canal treatment and pulpotomy. The patients will be followed clinically and radiographically for 2 years following the treatment. Predictors of the outcome of pulpotomy will be clinical and laboratory-based parameters.

Conditions

• Irreversible Pulpitis

Interventions

Type	Name	Description
PROCEDURE	RCT	This is the standard of care for this diagnosis
PROCEDURE	Pulpotomy	For cases with normal apical tissues, pulpotomy using tricalcium silicates has been shown to have high clinical success. Either partial or complete pulpotomy will be performed depending on the size of pulp exposure.

Timeline

• Start date: 2027-06-01
• Primary completion: 2030-06-30
• Completion: 2031-12-31
• First posted: 2021-06-10
• Last updated: 2026-02-17

Locations

1 site across 1 country: United States