NCT07466433

Apical Preparation Size in Regenerative Endodontics of Mature Teeth

The Effect of Apical Preperation Size on the Success of Regenerative Endodontic Treatment in Mature Teeth With Apical Periodontitis: A Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: Marmara University · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to learn whether the size of apical preparation affects the success of regenerative endodontic treatment in mature permanent teeth with apical periodontitis. Regenerative endodontic treatment is a procedure that aims to eliminate infection and support healing of the tissues around the root of the tooth. The main questions the study aims to answer are: * Does a larger apical preparation improve healing around the root tip? * Does apical preparation size affect pain after treatment or recovery of tooth vitality? Researchers compared two treatment approaches that use different apical preparation sizes to see if one leads to better clinical and radiographic healing. Participants: * Received regenerative endodontic treatment with one of two apical preparation sizes * Attended follow-up visits for clinical examination and radiographic evaluation * Were monitored for pain and healing outcomes during the follow-up period

Conditions

• Apical Periodontitis
• Mature Teeth
• Regenerative Endodontic Treatment

Interventions

Type	Name	Description
PROCEDURE	Regenerative Endodontic Treatment	Regenerative endodontic treatment (RET) is a biologically based procedure that includes root canal disinfection followed by placement of a biological scaffold to support tissue regeneration and periapical healing. In this study, the intervention differs according to the apical preparation size used (ISO 40 and ISO 80) in mature teeth with apical periodontitis.

Timeline

• Start date: 2024-07-29
• Primary completion: 2025-10-23
• Completion: 2025-10-23
• First posted: 2026-03-12
• Last updated: 2026-03-12

Locations

1 site across 1 country: Turkey (Türkiye)