| Active Not Recruiting | Reducing Antibiotic Use by Implementation of Stewardship in Primary and Urgent Care NCT07217002 | Children's Hospital of Philadelphia | — |
| Not Yet Recruiting | Efficacy of Two Nasal Products Based on Diluted Seawater in the Treatment of Upper Respiratory Infections/Cond NCT06498843 | YSLab | N/A |
| Recruiting | How OMT Benefits Newly Diagnosed Patients With Respiratory Illness When Given Alongside Other Standard Care. NCT06495021 | Geisinger Clinic | N/A |
| Active Not Recruiting | A Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal Polyps NCT06639295 | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | Phase 3 |
| Enrolling By Invitation | Harnessing Digital Medicine to Improve Allergic Rhinitis Management in Primary Care (DMAR) NCT06603935 | QHSLab, Inc. | N/A |
| Recruiting | Complicated Infections in Otorhinolaryngology NCT06023550 | University Medical Centre Ljubljana | — |
| Unknown | Auriculotherapy for Intraoperative Blood Pressure Control NCT06182982 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Completed | Using ChatGPT to Help Guide Treatment for Sinus and Nasal Problems NCT07140250 | Carol Yan | N/A |
| Completed | A Clinical Study of TQH2722 Injection in the Treatment of Chronic Sinusitis With or Without Nasal Polyps. NCT06089278 | Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. | Phase 2 |
| Unknown | A Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal Polyps NCT05865496 | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | Phase 2 |
| Unknown | "Association of Peri-implantitis and Maxillary Sinusitis: a Case-control Study". NCT05924711 | Universitat Internacional de Catalunya | — |
| Completed | MRI-based Synthetic CT Images of the Head and Neck NCT06016335 | Amsterdam UMC, location VUmc | N/A |
| Unknown | Establishment of Precise Diagnosis and Treatment System for Refractory Chronic Rhinosinusitis NCT05390255 | Beijing Tongren Hospital | Phase 3 |
| Unknown | Computed Tomography Anatomy of the Paranasal Sinuses and Anatomical Variants of Clinical Relevants in Egyptian NCT05301777 | Assiut University | — |
| Completed | A Study of Olynth Saline/Ectomed Nasal Drops/Spray Based Upon Previous Usage NCT05126407 | Johnson & Johnson Consumer Inc. (J&JCI) | — |
| Active Not Recruiting | Dupixent Study for Alternate Administration NCT06750471 | Madigan Army Medical Center | Phase 4 |
| Completed | Triamcinolone Packing Following Endoscopic Sinus Surgery NCT04841343 | University of California, Los Angeles | — |
| Completed | Dupilumab in CRSsNP NCT04678856 | Sanofi | Phase 3 |
| Unknown | Endoscopic Sinus Surgery in Recurrent Acute Rhinosinusitis NCT04241016 | Oulu University Hospital | N/A |
| Unknown | Efficacy and Safety of Modified Release Cefpodoxime Formulation in the Treatment of Acute Sinusitis. NCT03729258 | Neutec Ar-Ge San ve Tic A.Ş | Phase 3 |
| Completed | Pain Control Following Sinus Surgery NCT03783702 | Stanford University | Phase 4 |
| Unknown | The Effects of Steroid-eluting Stent Implant for the Treatment of Eosinophilic Chronic Rhinosinusitis With Nas NCT03943121 | Beijing Tongren Hospital | N/A |
| Unknown | The Long-Term Safety of Budesonide for Patients With Chronic Rhinosinusitis NCT03584178 | St. Paul's Hospital, Canada | N/A |
| Completed | Fluoroquinolone Associated Disability NCT03535558 | Janssen Research & Development, LLC | — |
| Completed | Safety of Intranasal Irrigation Probiotics in Healthy Volunteers NCT02933918 | Probionase Therapies Inc. | N/A |
| Completed | Best Practice in the Management of Concha Bullosa in FESS Operation NCT06687629 | Helsinki University Central Hospital | N/A |
| Completed | Xylitol for Chronic Sinusitis NCT03229551 | Ochsner Health System | Phase 2 / Phase 3 |
| Terminated | Foot Controlled Robotic Endoscope Enabled Robot FESS NCT03454607 | Chinese University of Hong Kong | N/A |
| Terminated | Trial of Topical Verapamil in Chronic Rhinosinusitis With Nasal Polyps NCT03102190 | Benjamin Bleier | Phase 1 |
| Completed | Study to Evaluate the Safety and Initial Effectiveness of the Sinusway™ for Endoscopy of Sinuses in Conjunctio NCT03390257 | 3NT Medical Ltd. | N/A |
| Recruiting | In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps NCT02975310 | Ottawa Hospital Research Institute | N/A |
| Unknown | Study Designed to Clinically Evaluate Sinus Wash Device Prototypes NCT02931604 | SinuSafe Medical LTD | N/A |
| Completed | Response of the Airway in Sinusitis and Asthma NCT03011632 | Medical University of Lodz | Phase 4 |
| Completed | Contamination Free Bacterial Swap NCT02924103 | Kåre Håkansson | N/A |
| Withdrawn | Gold Laser Vs. Micro-Debriders for Functional Endoscopic Sinus Surgery NCT02900794 | Texas Tech University Health Sciences Center | N/A |
| Unknown | Effect of Reslizumab in Chronic Rhinosinusitis NCT02799446 | Joshua S. Jacobs | Phase 3 |
| Active Not Recruiting | High Resolution Micro OCT Imaging NCT03256773 | University of Alabama at Birmingham | — |
| Completed | Study to Compare Resection Versus Preservation of the Middle Turbinate in Surgery for Nasal Polyps NCT02855931 | Université de Sherbrooke | N/A |
| Completed | Efficacy of Antibiotics in Children With Acute Sinusitis: Which Subgroups Benefit? NCT02554383 | Nader Shaikh | Phase 3 |
| Unknown | The Surgical Prognosis Based Diagnostic Strategy for Eosinophilic Chronic Rhinosinusitis NCT03374124 | Jianbo Shi | — |
| Terminated | Rates of Middle Meatus Synechiae Formation Post Endoscopic Sinus Surgery NCT02627794 | Cedars-Sinai Medical Center | Phase 3 |
| Terminated | Topical Irrigation Therapy for CRS NCT02630472 | University of Pennsylvania | Phase 1 / Phase 2 |
| Completed | Oral Steroids in Chronic Rhinosinusitis Without Nasal Polyps NCT02927834 | Loma Linda University | N/A |
| Completed | Safety and Effectiveness Evaluation of the Sinusway Device for Endoscopy of the Nasal Cavity and Paranasal Sin NCT02502084 | 3NT Medical Ltd. | N/A |
| Active Not Recruiting | Pilot Study of The EPIC Trial NCT02533206 | Ottawa Hospital Research Institute | N/A |
| Unknown | Endoscopic Sinus Surgery for Refractory Chronic Sinusitis NCT02506426 | University of Calgary | N/A |
| Unknown | Prednisone in Chronic Rhinosinusitis Without Nasal Polyps NCT02367118 | University of Chile | Phase 3 |
| Terminated | Trial of Verapamil in Chronic Rhinosinusitis NCT02454608 | Benjamin Bleier | N/A |
| Terminated | Rates of Middle Meatus Synechiae Formation Post ESS NCT03036735 | Steward St. Elizabeth's Medical Center of Boston, Inc. | N/A |
| Completed | SinuSys Patency of Frontal Recess and Sphenoid Sinus Ostia Study NCT02463279 | SinuSys Corporation | N/A |
| Unknown | Comparison of Nasal Saline Irrigation Bottle Contamination Between Two Solutions NCT02413125 | University of Virginia | N/A |
| Unknown | Rhinosinusites Chroniques NCT02407275 | Institut Hospitalo-Universitaire Méditerranée Infection | N/A |
| Completed | Comparison of Nasal Steroids After FESS in CRSwNP NCT02194062 | Yale University | N/A |
| Completed | Clinical Trial of the Treatment of Acute Sinusitis With Standard-dose Versus High-dose Amoxicillin/Clavulanate NCT02340000 | Albany Medical College | Phase 4 |
| Completed | Sinus Balloon Dilation in Pediatric Patients NCT02278484 | Entellus Medical, Inc. | N/A |
| Withdrawn | Association of Periostin Levels and Chronic Sinusitis NCT02071667 | University of Virginia | — |
| Completed | PerClot to Control Bleeding in Endoscopic Sinus Surgery NCT02221128 | CryoLife Europa | — |
| Completed | The Optimal Head Position for Distributing Topical Nasal Medication Using the Mucosal Atomization Device NCT02079792 | St. Paul's Hospital, Canada | Phase 4 |
| Completed | Comparison of Daily Mometasone Furoate Nasal Spray Alone Versus a Combination With Montelukast for Treatment o NCT02110654 | First Affiliated Hospital, Sun Yat-Sen University | Phase 4 |
| Completed | Efficacy and Safety for Medicurtain® in Prevention of Adhesion After Endoscopic Sinus Surgery (Pivotal Study) NCT05049434 | Shin Poong Pharmaceutical Co. Ltd. | N/A |
| Completed | Rates of Middle Meatal Synechia Formation Following Functional Endoscopic Sinus Surgery NCT02077322 | St. Paul's Hospital, Canada | N/A |
| Completed | Sinonasal Gas Exchange Dynamics NCT01671098 | Louisiana State University Health Sciences Center Shreveport | — |
| Completed | Evaluation of Inhaled Treatment in Sinusitis NCT01907204 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | Phase 2 / Phase 3 |
| Withdrawn | Pulmozyme in Cystic Fibrosis With Sinusitis NCT01155752 | Milton S. Hershey Medical Center | Phase 3 |
| Completed | Effect of Squeezable Bottle Nasal Irrigation Device in Children With Sinusitis NCT02191046 | Thammasat University | N/A |
| Withdrawn | Trial of Directed High-dose Nasal Steroids on Residual Smell Loss in Sinus Patients After Sinus Surgery NCT01814618 | University of North Carolina, Chapel Hill | Phase 2 |
| Completed | Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitis NCT01825408 | University of North Carolina, Chapel Hill | Phase 4 |
| Completed | Prophylactic Antibiotics After Functional Endoscopic Sinus Surgery: a Randomized, Double-blind Placebo Control NCT01919411 | Massachusetts Eye and Ear Infirmary | Phase 4 |
| Completed | Hot Saline Irrigation Study NCT01717274 | St. Paul's Hospital, Canada | N/A |
| Completed | Medical Therapy Versus Balloon Sinus Dilation for Patients With Chronic Rhinosinusitis NCT01685229 | Integra LifeSciences Corporation | — |
| Unknown | The Clinical Efficacy of Topical Nasal Pomegranate Fruit Extract for Patients With Chronic Rhinosinusitis NCT01564849 | Hillel Yaffe Medical Center | — |
| Completed | Trans-Nasal Maxillary Multi-Sinus Balloon Dilation Study NCT01612780 | Entellus Medical, Inc. | N/A |
| Completed | Safety and Performance of the SinuSys Dilation System for Dilation of the Maxillary Sinus Ostium NCT01623050 | SinuSys Corporation | Phase 1 |
| Completed | Application of Ectoin® Rhinitis Nasal Spray in Patients With Acute Rhinosinusitis NCT01684540 | Bitop AG | — |
| Completed | Sinusitis in Children and the Nasopharyngeal Microbiome NCT01492868 | University of Wisconsin, Madison | — |
| Completed | 15-Degree Tilt, Head Up, Feet Down Body Position for Sinus Surgery Patients NCT01442740 | St. Paul's Hospital, Canada | N/A |
| Completed | Medicated Punctured-Glove-Finger Spacer Study NCT01420471 | St. Paul's Hospital, Canada | Phase 4 |
| Completed | Development and Validation of a NIRS-based Sinusitis Screening NCT01485484 | University of California, Irvine | — |
| Completed | Manuka Honey Irrigation After Sinus Surgery NCT01350193 | St. Paul's Hospital, Canada | Phase 1 / Phase 2 |
| Unknown | The Effect of RF Turbinoplasty in Polypoid Change of Middle Turbinates NCT01906697 | Tehran University of Medical Sciences | Phase 3 |
| Unknown | A Study of Luffa Operculate Nasal Solution 5mg/mL Compared With Saline (NaCl 09%) for the Relief of Nasal Obst NCT01248325 | Zurita Laboratorio Farmaceutico Ltda. | Phase 3 |
| Completed | Short (5 Days) Versus Long (14 Days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Childr NCT01166945 | University of Wisconsin, Madison | N/A |
| Completed | Study of Asthma and Nasal Steroids NCT01118312 | JHSPH Center for Clinical Trials | Phase 4 |
| Completed | Optimization and Refinement of Technique in In-Office Sinus Dilation 2 NCT01107379 | Integra LifeSciences Corporation | — |
| Completed | XprESS Registry Study NCT01115309 | Entellus Medical, Inc. | N/A |
| Completed | Validation of the Facial and Cephalic Pain Inventory NCT01001039 | Greg Davis | — |
| Completed | Medical Therapy Versus Sinus Surgery for Chronic Rhinosinusitis: A Prospective, Multi-institutional Study NCT01255566 | Oregon Health and Science University | — |
| Completed | Olfactory Dysfunction of Rhinosinusitis - Cyclic Adenosine Monophosphate (cAMP)/Calcium Signaling Study NCT00970190 | Greg Davis | — |
| Completed | Efficacy of Azithromycin Prophylaxis in Preventing Recurrent Acute Sinusitis in Children NCT00944515 | Mahidol University | N/A |
| Completed | Prophylactic Efficacy of Relenza Against Influenza A and B NCT01156701 | GlaxoSmithKline | — |
| Completed | Home Usability of a Nasal Lavage System in Children NCT01129765 | Aardvark Medical Company | — |
| Completed | MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use NCT01050465 | University of Missouri-Columbia | N/A |
| Completed | Evaluation of the Middle Turbinate Implant for Affixing the Middle Turbinate to the Nasal Septum NCT00896883 | ENTrigue Surgical, Inc. | N/A |
| Withdrawn | Pilot Study To Evaluate A Pharmacologically Active Nasal Sponge Following Endoscopic Sinus Surgery NCT00705354 | Lahey Clinic | N/A |
| Unknown | Longitudinal Pathogen-colonization in Cystic Fibrosis Airways and Ability to Smell NCT00803881 | University of Jena | — |
| Completed | Clinical Study of Safety and Efficacy for the Relieva Stratus With Elution of Triamcinolone Acetonide NCT00791934 | Integra LifeSciences Corporation | N/A |
| Terminated | Study of the Use of LUMA Lightwire NCT00705237 | Lahey Clinic | Phase 4 |
| Completed | Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow NCT00634608 | University of Missouri-Columbia | N/A |
| Completed | Sinuclean's Treatment Of Sinusitis' Symptoms NCT00747747 | Galsor S.r.l. | Phase 4 |
| Unknown | Middle Meatal Bacteriology During Acute Respiratory Infection in Children NCT00545961 | Oulu University Hospital | Phase 4 |
| Completed | Balloon REmodeling Antrostomy THErapy Study NCT00645762 | Entellus Medical, Inc. | Phase 2 |
| Completed | Concentration of Itraconazole Solution in Nasal Secretions NCT00588016 | Mayo Clinic | Phase 1 |
| Completed | Comparing the Use of Saline or Saline Plus Gentamycin in Nasal Irrigation to Treat Chronic Sinusitis in Childr NCT00465530 | Julie Wei, MD | N/A |
| Completed | A Study To Investigate If MRI Scanning Is Effective At Seeing What Hayfever Drugs Do In Nasal Passage. NCT00517946 | GlaxoSmithKline | — |
| Completed | Nasally Delivered Pulmozyme for Sinusitis in Cystic Fibrosis NCT00416182 | University of Vermont | Phase 2 |
| Terminated | Effect of the Consumption of a Fermented Milk on Common Infections in Adults Submitted to Multi-stressor Situa NCT01315418 | Danone Global Research & Innovation Center | N/A |
| Terminated | The Study of Nasonex® Compared With Placebo for the Relief of Symptoms Associated With Acute Bacterial Sinusit NCT00423176 | Organon and Co | Phase 3 |
| Completed | Effect of the Consumption of a Fermented Milk on Common Infections in Shift-workers NCT01033799 | Danone Global Research & Innovation Center | N/A |
| Completed | Non-Rhinologic Etiologies of Headaches and Facial Pain in Tertiary Care Setting NCT00355160 | Penn State University | — |
| Completed | The Polymerase Chain Reaction (PCR) Analysis of Nasal Polyps for Fungal DNA NCT00739921 | University of California, San Francisco | N/A |
| Completed | Zmax Compared to Augmentin in Sinusitis NCT00367120 | Pfizer | Phase 4 |
| Terminated | Study to Evaluate the Efficacy and Safety of Moxifloxacin Versus Amoxicillin/Clavulanate in the Treatment of A NCT00493038 | Bayer | Phase 4 |
| Completed | Prevalence of Chronic Rhinosinusitis in Cystic Fibrosis NCT00266474 | University of Jena | — |
| Completed | Outcomes of Patients Not Responding to Antibiotics in the Community NCT00245427 | CPL Associates | N/A |
| Completed | A Study To Measure The Level Of Drug In Nasal Tissue And Blood After Taking A Single 2g Dose Or 500mg Tablets NCT00232154 | Pfizer | Phase 2 |
| Completed | Hemostatic Matrix in Endoscopic Sinus Surgery NCT00242437 | Ethicon, Inc. | Phase 4 |
| Completed | Maxillary Sinus Irrigation in the Management of Chronic Rhinosinusitis NCT00335309 | Ohad Ronen | N/A |
| Completed | Xolair in Patients With Chronic Sinusitis NCT00117611 | University of Chicago | Phase 4 |
| Completed | Antibiotics Versus Therapeutic Ultrasound for Sinusitis NCT00934830 | Norwegian University of Science and Technology | Phase 3 |
| Completed | BAY12-8039: 5 Days for Sinusitis vs Placebo NCT00492024 | Bayer | Phase 3 |
| Completed | CHOOSE : Telithromycin, Acute Bacterial Sinusitis NCT00174694 | Sanofi | Phase 4 |
| Completed | Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers NCT00208065 | Clinvest | Phase 4 |
| Completed | Guidelines for Acute Sinusitis NCT00132275 | University of Pittsburgh | N/A |
| Completed | Near Infrared Transillumination of the Paranasal Sinuses NCT00543998 | University of California, Irvine | — |
| Completed | Postoperative Treatment After Endoscopic Sinus Surgery NCT00534768 | Kuopio University Hospital | N/A |
| Completed | A Comparison of the Safety and Efficacy of Two Different Regimens of Levofloxacin in the Treatment of Acute Ba NCT00236522 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 3 |
| Completed | A Trial of Point of Care Information in Ambulatory Pediatrics NCT00368823 | University of Washington | Phase 3 |
| Completed | A Study of the Safety and Effectiveness of Levofloxacin Compared With Amoxicillin/Clavulanate Potassium in the NCT00249210 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 3 |
| Completed | Immunologic Aspects of the Pathogenesis of Chronic Sinusitis in Children NCT00004638 | National Center for Research Resources (NCRR) | N/A |
| Withdrawn | Preventing Frequent Sinus Infections in HIV-Infected Patients NCT00000752 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 2 |
| Completed | Acupuncture and Herbal Treatment of Chronic HIV Sinusitis NCT00002149 | Immune Enhancement Project | N/A |