NCT06016335

MRI-based Synthetic CT Images of the Head and Neck

Artificial Intelligence Driven Synthetic CT to Substitute CT Scans of the Head and Neck Region

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Amsterdam UMC, location VUmc · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In case of surgical procedures in the head and neck region, MRI in combination with CT of the bone is often the standard modality to visualise bony landmarks for planning, navigation and risk assessment. An important downside of a CT scan is the associated radiation exposure, especially in children. An additional downside is the sedation or general anaesthesia needed for both the MRI and CT scan session in very young children. These downsides could be removed if the CT scan can be substituted by an MRI sequence that can provide the same information as CT. This project aims to determine the feasibility of recreating CT like images of the craniofacial bones from MRI images using machine learning techniques.

Conditions

• Imaging of Bony Structures of the Head (Various Conditions)
• Hearing Loss
• Cholesteatoma
• Sinusitis
• Head and Neck Tumor

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	CT scan	Participants receive a CT scan of the head as part of their regular care. A larger part of the head will be scanned than for standard care.
DIAGNOSTIC_TEST	MRI scan	Participants receive an MRI scan, specifically for the purpose of the study.
OTHER	Synthetic CT scan	Synthetic CT scans will be generated from MRI scans, using the trained machine learning algorithm.

Timeline

• Start date: 2022-09-22
• Primary completion: 2023-09-12
• Completion: 2023-09-12
• First posted: 2023-08-29
• Last updated: 2023-12-19

Locations

1 site across 1 country: Netherlands