NCT02927834

Oral Steroids in Chronic Rhinosinusitis Without Nasal Polyps

The Role of Oral Steroids in the Management of Chronic Rhinosinusitis Without Nasal Polyps

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Loma Linda University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Chronic rhinosinusitis is a common disease that effects millions of people world wide. Despite its frequency it is unclear what treatment options are the best for these patients. Typically patients with chronic rhinosinusitis without nasal polyps (CRSsNP) are given a long term antibiotic (3 weeks), nasal steroid sprays, saline nasal irrigation and occasionally oral steroids. Oral steroids benefit patients with chronic rhinosinusitis with nasal polyps (CRSwNP) however their role in non polyp patients is less clear. It is the goal of this study to see if oral steroids benefit the treatment outcomes in those patients with chronic rhinosinusitis without nasal polyps. In addition this study will look to see if a short course (5 day burst) versus a longer course (21 day taper) of oral steroids make a difference in outcomes.

Detailed description

The investigators will compare patients with CRSsNP who are treated with antibiotics/nasal steroid sprays, and compare them to chronic sinusitis patients who receive antibiotics/nasal steroid spray along with a course of oral steroids. The goal is to determine if oral steroids have a role in CRSsNP, and if so, the most effective dosage.

Conditions

• Sinusitis

Interventions

Type	Name	Description
DRUG	6 day Prednisone	6 day prednisone burst
DRUG	Augmentin	Antibiotic augmentin for 3 weeks
DRUG	21 day Prednisone	21 day prednisone burst

Timeline

• Start date: 2015-08-01
• Primary completion: 2018-12-01
• Completion: 2019-01-01
• First posted: 2016-10-07
• Last updated: 2020-12-29
• Results posted: 2020-12-29

Locations

1 site across 1 country: United States