| Not Yet Recruiting | Shared Decision Making for Antipsychotic Medications NCT05416658 | New York State Psychiatric Institute | N/A |
| Not Yet Recruiting | Enhancing Veteran-Clinical Collaboration in VA PRRCs NCT06898879 | VA Office of Research and Development | N/A |
| Not Yet Recruiting | Cognitive Strategies in Early Psychosis 2 NCT07263022 | University of Minnesota | Phase 3 |
| Enrolling By Invitation | Incentives and Long-Acting Injectable Adherence After Involuntary Hospitalization NCT07130500 | Stanford University | N/A |
| Not Yet Recruiting | LRFN5 and OLFM4 in Schizoaffective Disorder NCT07447960 | Elazığ Mental Health and Diseases Hospital | — |
| Not Yet Recruiting | Improving Health Literacy in Patients With Schizophrenia Spectrum Disorder NCT07488156 | Louisiana State University Health Sciences Center in New Orleans | N/A |
| Recruiting | Acceptability, Feasibility and Preliminary Outcomes of the Kiso Mind App for Outpatients With Schizophrenia Sp NCT07395206 | Charite University, Berlin, Germany | N/A |
| Not Yet Recruiting | Impact of Medication Education on Adherence and Side Effects NCT07374588 | Cumhuriyet University | N/A |
| Recruiting | Synergy Between Physical Activity and Outdoor Green Environments to Reduce the Intensity of Negative Symptoms NCT07058389 | Centre Hospitalier Universitaire de Saint Etienne | N/A |
| Recruiting | Randomized Clinical Trial of iTEST: A Blended Intervention Targeting Introspective Accuracy NCT07098169 | University of California, San Diego | N/A |
| Recruiting | A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Re NCT07105111 | Neurocrine Biosciences | Phase 4 |
| Not Yet Recruiting | Therapeutic Improvement in People With Schizophrenia Undergoing tACS/CBTp (Transcranial Alternating Current St NCT06889025 | Felicia Iftene | N/A |
| Recruiting | Reduction of Anticholinergic Medications Among Persons With Schizophrenia or Other Psychiatric Disorders NCT07043803 | University of Pittsburgh | N/A |
| Recruiting | Context-Aware Mobile Intervention for Social Recovery in Serious Mental Illness (R33) NCT06865937 | University of California, San Diego | N/A |
| Recruiting | Exercise and Olanzapine-samidorphan NCT06740890 | New York State Psychiatric Institute | Phase 4 |
| Completed | Assessment of Acute Psychomotor Agitation Measures Associated With Schizophrenia and Bipolar Disorder NCT07116694 | BioXcel Therapeutics Inc | Phase 2 |
| Recruiting | Magnetic Seizure Therapy for Schizophrenia - Trial NCT06672588 | Centre for Addiction and Mental Health | N/A |
| Withdrawn | A Study to Evaluate the Safety and Tolerability of Long-Acting Oral Risperidone (LYN-005) in Participants With NCT06878833 | Lyndra Inc. | Phase 3 |
| Recruiting | 40 Hz Visual Stimulation as an Intervention in Schizophrenia NCT06907420 | Technical University of Munich | N/A |
| Active Not Recruiting | Cognitive Rehabilitation With Immersive Virtual Reality (IVR) in Schizophrenia: a Pilot Randomized Waiting Lis NCT07427485 | Azienda Sanitaria Locale Napoli 3 Sud, UOCSM Torre del Greco | N/A |
| Recruiting | Enhancing Rehabilitation for Veterans With Serious Mental Illness NCT06586164 | VA Office of Research and Development | N/A |
| Recruiting | Anticholinergic Deprescription in Schizophrenia NCT06562608 | Deepak K. Sarpal, M.D. | Phase 4 |
| Recruiting | Decision-Making in Schizophrenia: A Combined Neuroimaging and Experience Sampling Study NCT06745479 | Rutgers, The State University of New Jersey | N/A |
| Not Yet Recruiting | Obstructive Sleep Apnea Treatment in Serious Mental Illness NCT05457127 | University of California, San Diego | N/A |
| Not Yet Recruiting | Individual Placement and Support and/or Cognitive Remediation Therapy Added to TAU in Patients With Early Schi NCT03974620 | Pakistan Institute of Living and Learning | N/A |
| Enrolling By Invitation | Open Label Extension Study of NCT06221852 NCT06558201 | Mclean Hospital | N/A |
| Recruiting | Integrative Neuro-social Cognitive Strategy Programme for Instilling REcovery (INSPIRE) a Community-Based Cogn NCT06286202 | Singapore Institute of Technology | N/A |
| Recruiting | Cerebellar Modulation of Cognition in Psychosis NCT06107764 | Mclean Hospital | N/A |
| Recruiting | Effectiveness of Motivation Skills Training (MST) NCT05805397 | Columbia University | N/A |
| Recruiting | Effect of Neuroplasticity Modulation in tDCS Treatment Response Among Schizophrenia Patients With Auditory Hal NCT04629352 | National Institute of Mental Health and Neuro Sciences, India | N/A |
| Active Not Recruiting | Optimizing CBSST With Executive Function Training for Schizophrenia NCT06251193 | University of California, San Diego | N/A |
| Recruiting | Prediction and Intervention Effect of Rehabilitation Status for Severe Mental Disorder Patients Based on Multi NCT06904079 | Shanghai Mental Health Center | N/A |
| Recruiting | Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder NCT06221852 | Mclean Hospital | N/A |
| Recruiting | Enhanced Coordinated Specialty Care for Early Psychosis NCT06071858 | Mclean Hospital | N/A |
| Terminated | Horyzons: Implementation and Integration in Clinical Practice NCT06002958 | University of North Carolina, Chapel Hill | N/A |
| Recruiting | Accelerated Transcranial Magnetic Stimulation for People With Schizophrenia Treated With Clozapine NCT06003036 | Deepak K. Sarpal, M.D. | N/A |
| Completed | NST-SPARK: Preliminary Study of an Augmented Reality (AR) App Delivering Recovery-Oriented Cognitive Therapy f NCT06653829 | North Shore Therapeutics, Inc. | N/A |
| Withdrawn | Pilot Study 1: Efficacy and Safety of Sublingual Dexmedetomidine (BXCL501) for the Treatment of Agitation in t NCT05974527 | Brigham and Women's Hospital | Phase 4 |
| Recruiting | The Efficacy of Metacognitive Skills Training in the Context of Forensic Psychiatric Care NCT06005766 | University of Jyvaskyla | N/A |
| Unknown | SUCCEED Africa: Support, Comprehensive Care and Empowerment of People With Psychosocial Disabilities NCT06007105 | London School of Hygiene and Tropical Medicine | N/A |
| Completed | Motivation Skills Training for Schizophrenia NCT05746455 | Columbia University | N/A |
| Active Not Recruiting | EPI-MINN: Targeting Cognition and Motivation - National NCT05877716 | University of Minnesota | N/A |
| Recruiting | Improving Cognition Through Telehealth Aerobic Exercise and Cognitive Training After a First Schizophrenia Epi NCT05890183 | University of California, Los Angeles | N/A |
| Completed | Study of the Effectiveness of Valbenazine on Patient- and Clinician-Reported Outcomes in Participants With Tar NCT05859698 | Neurocrine Biosciences | Phase 4 |
| Completed | Comparison of Remimazolam and Etomidate As Induction Agents for Electroconvulsive Treatment NCT06664138 | Yeongseok Yun | Phase 4 |
| Completed | Study to Evaluate the Pharmacokinetics (PK) and Safety/Tolerability of Long-Acting Oral LYN-005 NCT05779241 | Lyndra Inc. | Phase 3 |
| Recruiting | Prebiotic Treatment in People With Schizophrenia NCT05527210 | University of Maryland, Baltimore | N/A |
| Recruiting | Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services NCT06740383 | Beth Israel Deaconess Medical Center | — |
| Unknown | Characterizing Response to Antipsychotics in Schizophrenia NCT06159322 | The Royal Ottawa Mental Health Centre | — |
| Unknown | Accelerated TMS in Psychosis NCT05567848 | Beth Israel Deaconess Medical Center | Phase 1 / Phase 2 |
| Completed | Dexmedetomidine in the Treatment of Agitation Associated With Schizophrenia and Bipolar Disorder (SERENITY III NCT05658510 | BioXcel Therapeutics Inc | Phase 3 |
| Completed | Service User and Staff Views on Digital Remote Monitoring for Psychosis NCT05670197 | Manchester Academic Health Science Centre | — |
| Unknown | Enhancing Educational and Vocational Recovery in Adolescents and Young Adults With Early Psychosis Through Sup NCT05824117 | Charite University, Berlin, Germany | N/A |
| Recruiting | Benefits of Combining MCT With CR in the Recovery of Patients With Psychotic Spectrum Disorders NCT06423651 | Universitat Autonoma de Barcelona | N/A |
| Unknown | Minocycline Augmentation of Clozapine for Treatment Resistant Schizophrenia NCT02533232 | Pakistan Institute of Living and Learning | Phase 1 |
| Completed | State Representation in Early Psychosis - Project 4 NCT05664594 | University of Minnesota | N/A |
| Completed | Remote State Representation in Early Psychosis NCT05538832 | University of Minnesota | EARLY_Phase 1 |
| Completed | Adapting and Examining Collaborative Decision Skills Training Among Veterans With Serious Mental Illness NCT04324944 | VA Office of Research and Development | N/A |
| Completed | Context-Aware Mobile Intervention for Social Recovery in Serious Mental Illness NCT05660070 | University of California, San Diego | N/A |
| Withdrawn | Exercise Target Brain Oscillations in Psychosis NCT05338424 | University of Minnesota | — |
| Completed | Luteolin for the Treatment of People With Schizophrenia NCT05204407 | University of Maryland, Baltimore | N/A |
| Completed | Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) and Substance Use: A Pilot Study NCT05380583 | Mclean Hospital | N/A |
| Recruiting | Development of a Model for Digital Monitoring of the Mental State of the Hospitalized Patient NCT06182787 | Sheba Medical Center | — |
| Completed | Study by Electroencephalography of the Link Between the Lack of Self-compassion and the Disorder of Empathy in NCT05464563 | Centre Hospitalier Henri Laborit | N/A |
| Recruiting | Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial NCT05208190 | New York State Psychiatric Institute | Phase 4 |
| Completed | Academic-Community EPINET (AC-EPINET) NCT04497857 | Indiana University | N/A |
| Terminated | Sodium Nitroprusside in Early Course Schizophrenia NCT04986072 | Beth Israel Deaconess Medical Center | Phase 2 |
| Recruiting | CLOZAPINE Response in Biotype-1 NCT04580134 | University of Texas Southwestern Medical Center | Phase 4 |
| Recruiting | Synbiotic Compound to Reduce Symptoms of Schizophrenia NCT04226898 | Sheppard Pratt Health System | Phase 2 |
| Completed | State Representation in Early Psychosis NCT05273164 | University of Minnesota | — |
| Completed | Mobile Self-Tracking of Mental Health NCT05023252 | VA Office of Research and Development | N/A |
| Completed | Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings NCT05030272 | Wake Forest University Health Sciences | N/A |
| Completed | Memantine Augmentation of Targeted Cognitive Training in Schizophrenia NCT04857983 | University of California, San Diego | Phase 2 / Phase 3 |
| Completed | eMove - Dance/Movement Therapy Study NCT05712928 | Drexel University | N/A |
| Completed | Feasibility of a Novel Process-based Treatment for Patients With Psychosis NCT04874974 | Max-Planck-Institute of Psychiatry | N/A |
| Active Not Recruiting | The OPUS YOUNG Trial. Early Intervention Versus Treatment as Usual for Adolescents With First-episode Psychosi NCT04916626 | Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital | N/A |
| Completed | M1 Schizophrenia PET Study NCT05105542 | Yale University | Phase 1 |
| Completed | Effect of Individual Cognitive Stimulation at Home in Adults With Psychotic Disorders NCT04783285 | CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas | N/A |
| Completed | Horyzons: Implementation in Clinical Practice NCT04673851 | University of North Carolina, Chapel Hill | N/A |
| Withdrawn | Effectiveness and Mechanisms of Recovery Oriented Cognitive Therapy NCT05140135 | University of Pennsylvania | N/A |
| Completed | Efficacy of Personalizing Cognitive Remediation for Schizophrenia by Targeting Impairments in Early Auditory P NCT04554121 | Columbia University | N/A |
| Completed | Neuromodulation of Social Cognitive Circuitry in People With Schizophrenia Spectrum Disorders NCT04418011 | Centre for Addiction and Mental Health | N/A |
| Completed | Pharmacologic Augmentation of Targeted Cognitive Training in Schizophrenia NCT04414930 | University of California, San Diego | Phase 2 |
| Completed | Feasibility Electrical Stimulation Study for Visual Hallucinations NCT04870710 | Beth Israel Deaconess Medical Center | N/A |
| Completed | Families With Substance Use and Psychosis: A Pilot Study NCT04284813 | Mclean Hospital | N/A |
| Completed | ED to EPI: Using SMS to Improve the Transition From the Emergency Department to Early Psychosis Intervention NCT04298450 | Centre for Addiction and Mental Health | N/A |
| Unknown | Assessing the Effect of Compensatory Cognitive Intervention Among People With Severe Mental Illness NCT04551027 | Shalvata Mental Health Center | N/A |
| Completed | Safety and Efficacy of Virtual Reality Mindfulness in Patients With Psychosis NCT05784948 | Chonbuk National University Hospital | N/A |
| Unknown | Survey on Pre-ECT Evaluation and ECT Application NCT04335916 | Klinički Bolnički Centar Zagreb | — |
| Completed | BXCL501 for Agitation in Schizophrenia NCT03708315 | Yale University | Phase 1 |
| Completed | Dexmedetomidine in the Treatment of Agitation Associated With Schizophrenia NCT04268303 | BioXcel Therapeutics Inc | Phase 3 |
| Completed | The Effects of Kynurenine Aminotransferase Inhibition in People With Schizophrenia NCT04013555 | University of Maryland, Baltimore | Phase 1 / Phase 2 |
| Completed | Evaluation of mHealth for Serious Mental Illness NCT04068467 | University of Washington | N/A |
| Completed | Early Psychosis Intervention - Spreading Evidence-based Treatment NCT03919760 | Centre for Addiction and Mental Health | N/A |
| Completed | Targeting Physical Health in Schizophrenia: Physical Activity Can Enhance Life Randomized Control Trial NCT04173572 | University of North Carolina, Chapel Hill | N/A |
| Unknown | Cognitive Behavioral Therapy for Insomnia (CBT-I) in Schizophrenia(SLEEPINS) NCT04144231 | Helsinki University Central Hospital | N/A |
| Unknown | Estradiol as add-on to Antipsychotics NCT04093518 | Tangent Data | Phase 3 |
| Unknown | Comparing Cognitive Remediation Approaches for Schizophrenia NCT04123223 | Wesleyan University | N/A |
| Completed | Theta tACS During Working Memory Training: A Pilot Study of the Effects on Negative Symptoms of Schizophrenia NCT04545294 | Tri-Service General Hospital | N/A |
| Completed | Novel Pharmacotherapy Approaches in Smokers With Serious Mental Illness NCT04011280 | University of California, San Diego | Phase 4 |
| Completed | Prebiotic Treatment in People With Schizophrenia - Pilot Study NCT03617783 | University of Maryland, Baltimore | Phase 4 |
| Completed | Maximizing the Impact of Neuroplasticity Using Transcranial Electrical Stimulation Study 2 NCT03896438 | University of Minnesota | N/A |
| Suspended | Cognitive Remediation for Coordinated Specialty Care NCT03930251 | New York State Psychiatric Institute | N/A |
| Completed | Persistence Targeted Smoking Cessation in Serious Mental Illness (SMI) NCT03873337 | Rutgers, The State University of New Jersey | N/A |
| Completed | Cognitive Adaption Training-Effectiveness in Real-world Settings and Mechanism of Action (CAT-EM) NCT03829280 | The University of Texas Health Science Center at San Antonio | N/A |
| Completed | Mobile CBT for Negative Symptoms NCT03621774 | University of California, San Diego | N/A |
| Completed | Overcoming Psychomotor Slowing in Psychosis (OCoPS-P) NCT03921450 | University of Bern | N/A |
| Completed | Improving Visual Attention in Schizophrenia NCT03880227 | The University of Texas at Dallas | N/A |
| Completed | Verbal Memory Training Using Virtual Reality in Schizophrenia NCT04251195 | The Royal Ottawa Mental Health Centre | N/A |
| Completed | Sodium Benzoate and/or N-Acetylcysteine Added to TAU in Patients With Early Schizophrenia Spectrum Disorder. NCT03510741 | Pakistan Institute of Living and Learning | Phase 2 |
| Recruiting | Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological Symptoms as Correlates NCT03495024 | Corporal Michael J. Crescenz VA Medical Center | Phase 4 |
| Completed | A Study to Determine Pharmacokinetic Characteristics of LY03010 Versus INVEGA SUSTENNA® in Schizophrenia Patie NCT03751488 | Luye Pharma Group Ltd. | Phase 1 |
| Completed | Targeting Physical Health in Schizophrenia: Physical Activity Can Enhance Life NCT03757988 | University of North Carolina, Chapel Hill | N/A |
| Completed | OnTrack>An Online Role-Playing Game for Young People With First Episode Psychosis NCT03390491 | Center for Social Innovation, Massachusetts | N/A |
| Completed | Motivation and Skills Support (MASS) NCT03404219 | Boston University Charles River Campus | N/A |
| Completed | Add-on HD Hf-tRNS Over Bilateral DLPFC for Treating Patients With Schizophrenia NCT04038788 | Tri-Service General Hospital | N/A |
| Completed | Improving Accessibility and Personalization of CR for Schizophrenia NCT03576976 | New York State Psychiatric Institute | N/A |
| Completed | Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder NCT03526354 | University of Massachusetts, Worcester | Phase 4 |
| Completed | Remediation of Visual Perceptual Impairments in People With Schizophrenia NCT03314129 | University of Rochester | N/A |
| Completed | Assessment of Efficacy of a Psychological Therapy in Inpatients With a Schizophrenic Psychosis NCT03316664 | Psychiatric University Hospital, Zurich | N/A |
| Completed | A Trial to Explore Acceptance and Performance of Using a Digital Medicine System With Healthcare Professionals NCT03568500 | Otsuka Pharmaceutical Development & Commercialization, Inc. | Phase 4 |
| Completed | Memantine Effects on Sensorimotor Gating and Neurocognition in Schizophrenia NCT03860597 | University of California, San Diego | Phase 4 |
| Completed | Texting for Relapse Prevention NCT02819349 | Center for Innovative Public Health Research | N/A |
| Completed | Feasibility and Relevance of High-Intensity Functional Training in Patients With First-Episode Psychosis NCT03409393 | Rigshospitalet, Denmark | N/A |
| Completed | Stimulating the Brain to Improve Self-Awareness NCT03370341 | The University of Texas at Dallas | N/A |
| Completed | Theta Burst Stimulation for Schizophrenia NCT03288779 | Duke University | N/A |
| Completed | Effectiveness of a Mobile Texting Intervention for People With Serious Mental Illness NCT03062267 | University of Washington | N/A |
| Completed | Neural Biomarkers of Clozapine Response NCT03076346 | University of Pittsburgh | — |
| Completed | Improving Neurocognitive Deficits and Function in Schizophrenia With Transcranial Magnetic Stimulation NCT03037983 | VA Office of Research and Development | N/A |
| Completed | The Effects of Bimodal tDCS on Illness Severity, Insight, Functional Outcomes, Neurocognition and HRV in Schiz NCT03701100 | Tri-Service General Hospital | N/A |
| Completed | Lifestyle Intervention for Young Adults With Serious Mental Illness NCT02815813 | Dartmouth-Hitchcock Medical Center | N/A |
| Completed | Virtual Reality Job Interview Training in Severe Mental Illness NCT03049813 | University of Michigan | N/A |
| Completed | Minnesota Community-Based Cognitive Training in Early Psychosis NCT03079024 | University of Minnesota | N/A |
| Unknown | Joint Crisis Plans or Crisis Cards for People With Severe Mental Disorders to Reduce Coercion in Psychiatric C NCT03240380 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Completed | The Appeal and Impact of E-cigarettes in Smokers With SMI NCT03050853 | Dartmouth-Hitchcock Medical Center | N/A |
| Unknown | Cognitive Behavioral Social Skills Training in Early Onset Psychosis NCT03261557 | Hospital Clinic of Barcelona | N/A |
| Completed | Sulforaphane to Reduce Symptoms of Schizophrenia NCT02810964 | Sheppard Pratt Health System | Phase 2 |
| Completed | Sustainable Early Episode Clinic Study (SEEC) NCT03571685 | Janssen Scientific Affairs, LLC | N/A |
| Completed | Comparing Thinking Skills for Work (TSW)Home Practice Program With Traditional TSW Program NCT03005574 | Boston University Charles River Campus | N/A |
| Completed | Clinical Trial of AVL-3288 in Schizophrenia Patients NCT02978599 | New York State Psychiatric Institute | Phase 1 |
| Unknown | A Randomised Controlled Trial of Coenzyme Q10 in Patients With Schizophrenia and Schizoaffective Disorder NCT03576911 | University of Dublin, Trinity College | N/A |
| Completed | Enhancing Cognitive Training Through Exercise Following a First Schizophrenia Episode NCT02823041 | University of California, Los Angeles | N/A |
| Completed | Schizophrenia and the Gut Microbiome NCT02921243 | University of Maryland, Baltimore | — |
| Withdrawn | Clonazepam Effects on Brain Oscillations and Cognition in Schizophrenia NCT03061136 | Palo Alto Veterans Institute for Research | Phase 4 |
| Completed | Study Investigating the Effect of Lu AF35700 on Cardiac Repolarization in Men and Women With Schizophrenia and NCT02901587 | H. Lundbeck A/S | Phase 1 |
| Completed | Cognitive Training Delivered Remotely to Individuals With Psychosis (ROAM) NCT02782442 | University of Minnesota | N/A |
| Terminated | MEtformin and Lorcaserin for WeighT Loss in Schizophrenia NCT02796144 | University of North Carolina, Chapel Hill | Phase 4 |
| Completed | Mobile-Assisted Cognitive Behavior Therapy for Negative Symptoms in Schizophrenia NCT03179696 | Eric Granholm | N/A |
| Completed | Raloxifene Augmentation in Patients With a Schizophrenia Spectrum Disorder NCT03043820 | Iris Sommer | Phase 3 |
| Recruiting | Switching From Twice-Daily to Once-Daily Clozapine Dosing in Schizophrenia NCT02639702 | Centre for Addiction and Mental Health | Phase 4 |
| Completed | The Effects of tDCS on Auditory Hallucination, Insight, Neurocognitive Function and HRV in Patients With Schiz NCT03388554 | Tri-Service General Hospital | N/A |
| Completed | Remediation of Auditory Recognition in Schizophrenia With tDCS NCT02869334 | New York State Psychiatric Institute | N/A |
| Completed | The Potential Efficacy of the Chinese Health Improvement Profile- A Pilot Clustered Randomised Controlled Tria NCT02453217 | Wai-Tong Chien | N/A |
| Completed | Motivational Negative Symptoms in Schizophrenia: Intervention and Biomarkers NCT02386605 | VA Office of Research and Development | N/A |
| Completed | Research Into Antipsychotic Discontinuation and Reduction Trial NCT03559426 | University College, London | Phase 4 |
| Completed | Targeting Cerebellum to Treat Psychosis: a Transcranial Magnetic Stimulation (TMS) Study NCT02642029 | Mclean Hospital | N/A |
| Terminated | A Pilot Trial of Curcumin Effects on Cognition in Schizophrenia NCT02476708 | Yale University | N/A |
| Unknown | Remote Monitoring and Support for Patients With Schizophrenia, Schizoaffective or Bipolar Disorder on Adherenc NCT02665611 | Assuta Hospital Systems | N/A |
| Completed | Positive Emotions Program for Schizophrenia (PEPS) NCT02593058 | Institut et Haute Ecole de la Santé la Source | N/A |
| Withdrawn | Transcranial Direct Current Stimulation for Hallucinations in First-Episode Schizophrenia NCT02661347 | Northwell Health | N/A |
| Completed | Cannabidiol Treatment in Patients With Early Psychosis NCT02504151 | Yale University | Phase 2 |
| Completed | Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment With Antipsychotics NCT02573168 | St. Joseph's Healthcare Hamilton | N/A |
| Completed | Video as a Tool to Improve Insight in Schizophrenia NCT02664129 | University Hospital, Montpellier | N/A |
| Completed | Estradiol Patch as add-on to Antipsychotics in Patients With Schizophrenia, Schizoaffective or Schizophrenifor NCT03848234 | Tangent Data | Phase 3 |
| Completed | A Study of Aripiprazole Lauroxil in Subjects With Schizophrenia or Schizoaffective Disorder NCT02636842 | Alkermes, Inc. | Phase 1 |
| Completed | Development of a Mobile System for Self-management of Schizophrenia (SOS) NCT01969500 | Dartmouth-Hitchcock Medical Center | N/A |
| Completed | Modified Psychodynamic Psychotherapy for Patients With Schizophrenia NCT02576613 | Charite University, Berlin, Germany | N/A |
| Completed | RISE (Rehabilitation Intervention for People With Schizophrenia in Ethiopia) NCT02160249 | London School of Hygiene and Tropical Medicine | N/A |
| Completed | Comparison of E-health vs. In-person Multi-Family Group (MFG) NCT02032680 | VA Office of Research and Development | N/A |
| Completed | Pentosan Polysulfate Sodium and Meclofenamic Acid as Treatments in Patients With Psychotic Disorders NCT02930005 | The University of Texas Health Science Center, Houston | Phase 2 |
| Unknown | Evaluating the Efficacy of a Late-Life Schizophrenia Integrated Care Pathway to Treat Acute Psychotic Symptoms NCT02529163 | Centre for Addiction and Mental Health | N/A |
| Completed | Comparative Effectiveness of Adaptive Treatment Strategies for Schizophrenia NCT02775864 | New York State Psychiatric Institute | — |
| Completed | Building Employment Skills Through Therapy for Veterans NCT01992913 | VA Office of Research and Development | N/A |
| Completed | Comparing Mobile Health (mHealth) and Clinic-Based Self-Management Interventions for Serious Mental Illness NCT02421965 | Dartmouth-Hitchcock Medical Center | N/A |
| Completed | OnTrack>An Online Role-Playing Game: A Small Business Innovation Research (SBIR) Grant NCT02415764 | Center for Social Innovation, Massachusetts | Phase 1 |
| Terminated | A Study to Assess the Clinical Utility of Antipsychotic Medication Levels in Plasma as Determined by Liquid Ch NCT02462473 | Janssen Research & Development, LLC | Phase 2 |
| Completed | STimulation to Improve Auditory haLLucinations NCT02360228 | University of North Carolina, Chapel Hill | N/A |
| Completed | Exercise and Cognitive Training NCT02326389 | Boston University Charles River Campus | N/A |
| Unknown | A Pharmacokinetic Study of Paliperidone ER NCT02433717 | National Taiwan University Hospital | Phase 4 |
| Completed | A New Paradigm for Illness Monitoring and Relapse Prevention in Schizophrenia NCT01952041 | Dartmouth-Hitchcock Medical Center | N/A |
| Completed | Task Sharing for the Care of Severe Mental Disorders in a Low-income Country NCT02308956 | University of Cape Town | Phase 3 |
| Completed | Safety and PK Trial With Injectable ZX003 (Risperidone-SABER®) Compared to Risperdal® Consta® in Stable Schizo NCT02411526 | Zogenix, Inc. | Phase 1 |
| Completed | Fixed Dose Intervention Trial of New England Enhancing Survival in SMI Patients NCT02188121 | Mclean Hospital | Phase 4 |
| Completed | Minocycline Augmentation to Clozapine NCT02124811 | Emory University | Phase 4 |
| Withdrawn | Targeted Vitamin D Treatment of Schizophrenia-Associated Hyperprolinemia NCT02197286 | NYU Langone Health | Phase 2 |
| Completed | Self-Management Training and Automated Telehealth to Improve SMI Health Outcomes NCT02188732 | Dartmouth-Hitchcock Medical Center | N/A |
| Completed | Nicotinic Enhancement of Cognitive Remediation Training in Schizophrenia NCT02069392 | University of Maryland, Baltimore | N/A |
| Unknown | Magnesium Variations and Cardiometabolic Risk in Patients With Antipsychotic Drugs NCT02986490 | University Hospital, Montpellier | N/A |
| Terminated | Galantamine and Memantine Combination for Cognitive Impairments in Schizophrenia NCT02234752 | Sheppard Pratt Health System | Phase 2 |
| Completed | Exenatide Weekly Injections as an Adjunctive Treatment in Patients With Schizophrenia NCT02417142 | University of Massachusetts, Worcester | Phase 4 |
| Completed | Bioavailability of LY03004 and Risperdal® Consta® NCT02091388 | Luye Pharma Group Ltd. | Phase 1 |
| Completed | Prediction of Relapse in Schizophrenia/Schizoaffective Disorder With Smartphones and On-body Sensors NCT02224430 | University of Alabama at Birmingham | — |
| Completed | Cognitive Remediation Therapy Within a Secure Forensic Setting NCT02360813 | Central Mental Hospital | N/A |
| Unknown | Perceptual Deficits in Schizophrenia NCT02337439 | VA Connecticut Healthcare System | N/A |
| Completed | Effect of MMFS-202-302 on Cognitive Enhancement in Schizophrenia NCT02237235 | Northwestern University | Phase 2 |
| Completed | Prospective Pharmacogenetic Testing and Clinical Outcomes in Patients With Early-Phase Psychosis NCT02566057 | Northwell Health | N/A |
| Completed | An Randomized Open-Label PK Study of LY03004 Compared to Risperdal® Consta® in Stable Patients With Schizophre NCT02186769 | Luye Pharma Group Ltd. | Phase 1 |
| Terminated | Prednisolone Addition for Patients With Recent-onset Psychotic Disorder NCT02949232 | UMC Utrecht | Phase 4 |
| Unknown | Electroconvulsive Therapy in Clozapine-resistant Schizophrenia NCT02159001 | Niuvanniemi Hospital | N/A |
| Completed | Integrated Metacognitive Therapy in First Episode Psychosis NCT02131116 | Indiana University | N/A |
| Completed | A Concierge Model of CAE Plus LAI in Individuals With Schizophrenia at Risk for Treatment Non-adherence and Ho NCT02085447 | University Hospitals Cleveland Medical Center | N/A |
| Completed | rTMS in First Episode Psychosis NCT02131129 | Indiana University | N/A |
| Completed | Psychosocial Intervention to Reduce Self-stigma and Improve Quality of Life Among People With Mental Illness i NCT03197168 | University of Chile | N/A |
| Completed | D-Cycloserine Augmentation of Cognitive Behavioral Therapy for Delusions NCT01981759 | NYU Langone Health | Phase 4 |
| Completed | Tocilizumab as Add-On Treatment For Residual Positive, Negative, and Cognitive Symptoms of Schizophrenia NCT02034474 | New York State Psychiatric Institute | Phase 4 |
| Unknown | Measuring the Effect of Remote Monitoring of Treatment Adherence on the Risk of Re-admission of Ambulatory Sch NCT01729572 | Shalvata Mental Health Center | N/A |
| Completed | Transcranial Current Stimulation as a Treatment for Auditory Hallucinations in Schizophrenia NCT01963676 | University of North Carolina, Chapel Hill | N/A |
| Completed | Glutamate, Brain Connectivity and Duration of Untreated Psychosis NCT02034253 | University of Alabama at Birmingham | — |
| Completed | Oxytocin and CBSST for People With Schizophrenia NCT01752712 | University of Maryland, Baltimore | N/A |
| Completed | Pilot-trial of Emotion-focused Cognitive Behavior Therapy for Patients With Schizophrenia NCT02787122 | Philipps University Marburg | N/A |
| Completed | RCT of Methotrexate Added to Treatment As Usual in Schizophrenia NCT02074319 | Pakistan Institute of Living and Learning | Phase 1 |
| Completed | Enhancing Cognitive Training Through Exercise After a First Schizophrenia Episode NCT02267070 | University of California, Los Angeles | N/A |
| Completed | Simvastatin Addition for Patients With Recent-onset Schizophrenia NCT01999309 | Iris Sommer | Phase 3 |
| Completed | Neuroendocrine and Immune Response to Stress in Schizophrenia NCT01975584 | University of Maryland, Baltimore | N/A |
| Terminated | Examining Dose-Related Effects of Oxytocin on Social Cognition Across Populations NCT02149823 | Maria de las Mercedes Perez Rodriguez | Phase 1 |
| Completed | Personalized and Scalable Cognitive Remediation Approaches NCT01945333 | New York State Psychiatric Institute | N/A |
| Completed | Targeted Self-Management for Epilepsy and Serious Mental Illness (TIME) NCT01992393 | Case Western Reserve University | N/A |
| Completed | rTMS for Working Memory Deficits in Schizophrenia NCT01880255 | Centre for Addiction and Mental Health | N/A |
| Completed | Get Moving and Get Well - Pilot Study NCT01884025 | VA Office of Research and Development | N/A |
| Completed | Naltrexone for Antipsychotic-Induced Weight Gain NCT01866098 | Yale University | N/A |
| Completed | Omega-3 Dietary Supplements in Schizophrenia NCT01786239 | Delbert Robinson | N/A |
| Completed | Effectiveness of Adherence Therapy for Schizophrenia NCT01780116 | The Hong Kong Polytechnic University | Phase 1 / Phase 2 |
| Completed | Improving Care and Reducing Cost Study NCT02364544 | Northwell Health | N/A |
| Terminated | Antipsychotic Effects on Brain Function in Schizophrenia NCT01913327 | University of California, San Francisco | Phase 4 |
| Completed | Withania Somnifera: an Immunomodulator and Anti-inflammatory Agent for Schizophrenia NCT01793935 | K.N. Roy Chengappa | N/A |
| Completed | Pharmacokinetic, Safety, and Tolerability Study of Risperidone ISM® at Different Dose Strengths NCT01788774 | Rovi Pharmaceuticals Laboratories | Phase 1 |
| Unknown | Efficacy of Repetitive Transcranial Magnetic Stimulation in the Prevention of Relapse of Schizoaffective NCT02221635 | Xijing Hospital | — |
| Completed | Pharmacokinetic and Safety Study of LY03004 in Stable Patients With Schizophrenia or Schizoaffective Disorder NCT02055287 | Luye Pharma Group Ltd. | Phase 1 |
| Unknown | Navigated αTMS in Treatment-resistant Schizophrenia NCT01941251 | Niuvanniemi Hospital | N/A |
| Completed | Valacyclovir Augmentation for Cognitive and Functional Remediation in Schizophrenia NCT01794897 | University of Pittsburgh | Phase 4 |
| Completed | Adherence in Patients Admitted to a Psychiatric Unit for Acute Psychosis: an Analysis of Serum Levels of Antip NCT01786369 | Northwell Health | — |
| Completed | Lurasidone Effects on Tissue Glutamate in Schizophrenia NCT02199743 | University of Texas Southwestern Medical Center | Phase 4 |
| Unknown | Adherence and Quality of Life in People With Schizophrenia and Schizoaffective Disorder NCT01769014 | Psychiatrische Dienste Graubuenden | — |
| Terminated | Contrasting Group Therapy Methods for Psychosis NCT01764568 | University of British Columbia | N/A |
| Completed | Agomelatine Treatment of Depression in Schizophrenia (AGOPSYCH) NCT01822418 | Central Institute of Mental Health, Mannheim | Phase 4 |
| Completed | Study of Lurasidone in Treating Antipsychotic Naive or Quasi-Naive Children and Adolescents NCT01731119 | University of North Carolina, Chapel Hill | Phase 2 |
| Completed | Lifestyle Intervention for Diabetes and Weight Management in Psychosis NCT01828931 | Centre for Addiction and Mental Health | N/A |
| Completed | Probiotics to Prevent Relapse After Hospitalization for Mania NCT01731171 | Sheppard Pratt Health System | N/A |
| Completed | Kuvan in People With Schizophrenia and Schizoaffective Disorder NCT01706965 | New York State Psychiatric Institute | Phase 1 / Phase 2 |
| Completed | Evaluating Isradipine for Cognitive Enhancement in Schizophrenia and Schizoaffective Disorder NCT01658150 | Icahn School of Medicine at Mount Sinai | N/A |
| Completed | Understanding How Cognitive Remediation Works NCT01683539 | Boston University Charles River Campus | N/A |
| Completed | Brain Imaging, Cognitive Enhancement and Early Schizophrenia NCT01561859 | Beth Israel Deaconess Medical Center | N/A |
| Completed | Comparison of Antipsychotic Combination Treatment of Olanzapine and Amisulpride to Monotherapy NCT01609153 | Heinrich-Heine University, Duesseldorf | Phase 4 |
| Completed | PTSD (PostTraumatic Stress Disorder) Services for Veterans With SMI (Severe Mental Illness) NCT01542229 | VA Office of Research and Development | N/A |
| Terminated | Assessing the Effects of Fanapt® on Social Cognition in Schizophrenia NCT01929889 | Northwestern University | Phase 4 |
| Completed | Antipsychotics and Risk of Hyperglycemic Emergencies NCT02582736 | Canadian Network for Observational Drug Effect Studies, CNODES | — |
| Completed | POC Study of Pipamperone Added to Stable Treatment With RIS or PAL in Chronic Schizophrenia NCT01450514 | PharmaNeuroBoost N.V. | Phase 2 |
| Completed | Efficacy and Safety of A-prexa Compared to Zyprexa in Patients With Schizophrenia NCT02137993 | HK inno.N Corporation | Phase 4 |
| Unknown | N-methyl-D-aspartic Acid (NMDA) and Cognitive Remediation in Schizophrenia NCT01474395 | Nathan Kline Institute for Psychiatric Research | Phase 2 |
| Completed | Magnetic Seizure Therapy (MST) for Treatment Resistant Depression, Schizophrenia, and Obsessive Compulsive Dis NCT01596608 | Centre for Addiction and Mental Health | N/A |
| Completed | Selective Estrogen Receptor Modulators (SERMs) - A Potential Treatment for Psychotic Symptoms of Schizophrenia NCT01481883 | The Alfred | Phase 4 |
| Completed | RP5063 in Subjects With Schizophrenia or Schizoaffective Disorder NCT01490086 | Reviva Pharmaceuticals | Phase 2 |
| Completed | Life Goals Collaborative Care to Improve Health Outcomes in Mental Disorders NCT01487668 | VA Office of Research and Development | N/A |
| Terminated | Social Cognition in Longstanding Psychosis NCT01624831 | University of Arizona | — |
| Completed | Reducing Internalized Stigma in People With Serious Mental Illness NCT01259427 | VA Office of Research and Development | Phase 2 |
| Completed | Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia NCT01431092 | Lone Baandrup | Phase 4 |
| Completed | Oxytocin Treatment of Social Cognitive and Functional Deficits in Schizophrenia NCT01394471 | University of North Carolina, Chapel Hill | Phase 1 |
| Unknown | F-18 Altanserin PET Study of Patients Receiving Clozapine NCT01398189 | Seoul National University Bundang Hospital | N/A |
| Completed | Trial to Evaluate the Effects of OPC-34712 on QT/QTc in Subjects With Schizophrenia or Schizoaffective Disorde NCT01423916 | Otsuka Pharmaceutical Development & Commercialization, Inc. | Phase 1 |
| Completed | Nicotinic Receptors and Schizophrenia NCT01400477 | University of Colorado, Denver | Phase 2 |
| Recruiting | Brain Health and Exercise in Schizophrenia NCT01392885 | BC Mental Health and Addictions Research Institute | — |
| Completed | L-arginine add-on Therapy in Patients With Schizophrenia NCT02398279 | Hacettepe University | N/A |
| Completed | Salsalate as an Adjunctive Treatment for Patients With Schizophrenia NCT01578486 | University of Massachusetts, Worcester | Phase 4 |
| Completed | The Effect of N-Acetyl Cysteine on Cortical Erosion in Early Stage Schizophrenia NCT01339858 | Indiana University | Phase 4 |
| Completed | Optimization of Treatment and Management of Schizophrenia in Europe (OPTIMISE): Substudy Site Copenhagen NCT01555814 | Birte Glenthoj | N/A |
| Completed | Optimization of Treatment and Management of Schizophrenia in Europe NCT01248195 | Rene Kahn | Phase 4 |
| Completed | Pharmacologic and Clinical Testing of a D1 Agonist for Cognitive Enhancement in Neuropsychiatric Disorders NCT01519557 | New York State Psychiatric Institute | EARLY_Phase 1 |
| Completed | Selective Estrogen Receptor Modulators for Women of Child-bearing Age With Schizophrenia NCT02354001 | The Alfred | Phase 4 |
| Unknown | Minocycline, Acetylsalicylic Acid or Pramipexole vs Placebo in Patients With Schizophrenia or Schizoaffective NCT01320982 | Sheba Medical Center | Phase 3 |
| Unknown | Raloxifene in Treatment of Schizophrenia and Schizoaffective Disorder NCT01280305 | Sheba Medical Center | Phase 3 |
| Completed | A Comparison of Long-acting Injectable Medications for Schizophrenia NCT01136772 | New York State Psychiatric Institute | Phase 4 |
| Unknown | Pregnenolone and L-theanine Augmentation in the Treatment for Schizophrenia and Schizoaffective Disorders NCT01831986 | Sha'ar Menashe Mental Health Center | N/A |
| Completed | Brain Circuits in Schizophrenia and Smoking NCT01425684 | University of Maryland, Baltimore | — |
| Completed | Neural Oscillations as Genetic and Functional Biomarkers in Normal and Disease States NCT01425671 | University of Maryland, Baltimore | — |
| Completed | An Epidemiological Study to Assess the Psychosocial and Symptomatic Remission and Community Integration Status NCT01309373 | Janssen-Cilag, S.A. | — |
| Unknown | The Antiatherogenic Properties of HDL in Psychiatric Patients With and Without Antipsychotic Therapy NCT01215383 | Ziv Hospital | — |
| Completed | Multi-disciplinary Treatment for Patients Experiencing First Episode of Psychosis NCT01216891 | Research Foundation for Mental Hygiene, Inc. | N/A |
| Terminated | Decision Aid to Facilitate Shared Decision Making During Treatment in Schizophrenia NCT01420575 | VA Nebraska Western Iowa Health Care System | N/A |
| Completed | Effectiveness of Ziprasidone for Patients With Schizophrenia NCT01198353 | Soonchunhyang University Hospital | Phase 4 |
| Completed | A Study to Evaluate the Efficacy of Paliperidone Palmitate in the Prevention of Relapse of the Symptoms of Sch NCT01193153 | Janssen Scientific Affairs, LLC | Phase 3 |
| Completed | Adapted Cognitive/Affective Remediation for Cannabis Misuse in Schizophrenia NCT01292577 | University of Pittsburgh | Phase 1 / Phase 2 |
| Completed | Randomized Double Blind Placebo Control Study in Patients with Schizophrenia NCT01602029 | Pakistan Institute of Living and Learning | Phase 2 |
| Unknown | Reduction of Cardiovascular Risk in Severe Mental Illness NCT01182012 | Consorci Hospitalari de Vic | Phase 4 |
| Completed | A Study of Subjects Switched to Lurasidone for the Treatment of Schizophrenia or Schizoaffective Disorder NCT01143090 | Sumitomo Pharma America, Inc. | Phase 3 |
| Completed | Double-Blind Trial of a Probiotic Supplement to Reduce the Symptoms of Schizophrenia NCT01242371 | Sheppard Pratt Health System | N/A |
| Completed | An Integrated Program for the Treatment of First Episode of Psychosis NCT01321177 | Northwell Health | N/A |
| Completed | Multifamily Psychoeducation and Cognitive Remediation for Recent-Onset Psychosis NCT01196286 | University of Arizona | N/A |
| Completed | A Study Evaluating Lurasidone for The Treatment of Schizophrenia or Schizoaffective Disorder in Subjects Switc NCT01143077 | Sumitomo Pharma America, Inc. | Phase 3 |
| Completed | Nonconvulsive Electrotherapy: a Proof-of-concept Trial NCT01065597 | University of Maryland, College Park | Phase 1 |
| Unknown | Effects of Gene Polymorphisms on Metabolic Features in Clozapine-treated Patients With Schizophrenia NCT01324167 | Taipei Medical University WanFang Hospital | — |
| Completed | Smoking Cessation for Veterans With Severe and Persistent Mental Illness NCT00960375 | US Department of Veterans Affairs | Phase 2 / Phase 3 |
| Completed | Factors Association With Poor Physical Function in Older Adults With Schizophrenia NCT01092598 | University of California, San Francisco | — |
| Completed | Effect of Varenicline on Cognitive Function in Cigarette Smokers With Schizophrenia NCT01093365 | Centre for Addiction and Mental Health | Phase 2 |
| Active Not Recruiting | Database Registry for Neural Network Biomarkers in Psychosis NCT01409109 | University of Texas Southwestern Medical Center | — |
| Completed | Prevention of Weight Gain in Early Psychoses NCT01075295 | Centre for Addiction and Mental Health | N/A |
| Completed | Mediators and Moderators of Treatment Outcome in Recent-Onset Psychosis NCT01570972 | University of Arizona | N/A |
| Completed | Remediation of Working Memory in Schizophrenia NCT00995553 | VA Office of Research and Development | N/A |
| Completed | Study of Vitamin D in the Severely Mentally Ill NCT01169142 | Bronx Psychiatric Center | Phase 4 |
| Completed | Efficacy of an Early Antipsychotic Switch in Case of Poor Initial Response to the Treatment of Schizophrenia NCT01029769 | Technical University of Munich | N/A |
| Completed | Pregnenolone for Cognitive and Negative Symptoms in Schizophrenia NCT00728728 | VA Office of Research and Development | Phase 2 |