NCT06003036

Accelerated Transcranial Magnetic Stimulation for People With Schizophrenia Treated With Clozapine

Accelerated Neuromodulation of Prefrontal Circuitry During Clozapine Treatment

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Deepak K. Sarpal, M.D. · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

In this study, the investigators will examine whether a type of repetitive transcranial magnetic stimulation called accelerated intermittent theta burst stimulation (iTBS) can augment neurocognition in individuals who receive treatment with clozapine. Following a baseline evaluation and magnetic resonance imaging (MRI), participants will undergo a session of iTBS +MRI and session of sham delivery + MRI. The order for these sessions will be blinded and randomized. The investigators predict that accelerated iTBS will enhance neurocognition relative to sham delivery.

Conditions

• Schizophrenia
• Schizoaffective Disorder

Interventions

Type	Name	Description
DEVICE	sham stimulation	sham delivery of transcranial magnetic stimulation
DEVICE	transcranial magnetic stimulation	accelerated intermittent theta burst stimulation

Timeline

• Start date: 2023-12-01
• Primary completion: 2026-02-28
• Completion: 2026-07-01
• First posted: 2023-08-21
• Last updated: 2026-04-13

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study