NCT05273164

State Representation in Early Psychosis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 277 (actual)
• Sponsor: University of Minnesota · Academic / Other
• Sex: All
• Age: 15 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to examine state representation in individuals aged 15-45 who have been diagnosed with a psychotic illness, as well as young adults who do not have a psychiatric diagnosis. State Representation is our ability to process information about our surroundings. Participants will complete computerized tasks that measure state representation while having their brain activity measured.

Detailed description

Participants will be asked to complete two sets of appointments six months apart. During both sets of appointments, participants will be asked to complete interviews examining behaviors and symptoms of mental health conditions, self-report questionnaires, and a neurocognitive assessment. In addition, participants will complete an imaging appointment, in which they will receive simultaneous electroencephalography (EEG) and functional Magnetic Resonance Imaging (fMRI) while performing two computerized tasks. The purpose of this study is to determine how differences in information processing that support state representation in neural circuits relate to clinical heterogeneity in early psychosis. To this end, the investigators will: (a) Recruit people with early psychosis and demographically similar adults without a psychiatric illness aged 15-45 years; (b) Determine test-retest reliability of variants of the Dot Pattern Expectancy (DPX) and Bandit tasks as assessments of state representation processes; (c) Characterize behavioral performance and neurophysiology at baseline using the DPX and Bandit task variants during simultaneous EEG-fMRI along with other MRI modalities; (d) Follow patients for 6 months while they receive usual care, to delineate their clinical trajectories; (e) Repeat the behavioral and EEG-fMRI assessments after six months. The data the investigators acquire will allow us to examine the baseline relationships between clinical and experimental measures, and also to investigate how changes in clinical and experimental measures are related over a 6-month time period during a critical phase of illness. Participants in this protocol will be invited to participate in a follow on study, NCT05664594.

Conditions

• Psychosis
• Schizophrenia
• Schizophrenia Spectrum and Other Psychotic Disorders
• Schizoaffective Disorder

Timeline

• Start date: 2021-12-01
• Primary completion: 2025-08-29
• Completion: 2025-08-29
• First posted: 2022-03-10
• Last updated: 2025-09-22

Locations

1 site across 1 country: United States