| Recruiting | A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score NCT07098611 | Medipol University | — |
| Recruiting | High-Flow Nasal Cannula vs. NIV After Extubation in Children Undergoing Heart Surgery NCT07059689 | Indonesia University | N/A |
| Enrolling By Invitation | Epidemiology of Non- Invasive Mechanical Ventilation in Argentina: a Multicenter Observational Study NCT06837402 | Argentinian Intensive Care Society | — |
| Recruiting | Susceptibility for Entrainment: Role of Ventilator Settings on the Occurrence of Reverse Triggering and Its Ph NCT06293976 | Unity Health Toronto | N/A |
| Recruiting | Optimal Timing for Spontaneous Breathing Trials NCT06561295 | Rush University Medical Center | N/A |
| Completed | Superiority Trial Between Sotair® Device Attached to Manual Resuscitator Versus Ventilation Alone NCT06261619 | Rhode Island Hospital | N/A |
| Completed | Brain Recovery With Automated VEntilation NCT06367816 | University of Genova | — |
| Enrolling By Invitation | Pivotal Evaluation of Abdominal Neuromuscular Electrical Stimulation (VentFree) for Weaning From Mechanical Ve NCT05759013 | Liberate Medical | N/A |
| Recruiting | Non-inferiority Trial Between Sotair® Device Attached to Manual Resuscitator Versus Mechanical Ventilation NCT06117683 | Rhode Island Hospital | N/A |
| Completed | Association Between Tidal Volume and Mortality in Pressure Support in Adults Under Invasive Mechanical Ventila NCT06195475 | Sanatorio Anchorena San Martin | — |
| Completed | Musical Intervention and Physiological Stress and Inflammatory Biomarkers in Mechanically Ventilated ICU Patie NCT06120660 | University of Oviedo | N/A |
| Completed | Parasternal Intercostal Ultrasound vs RSBI for Weaning Prediction NCT07144878 | Benha University | N/A |
| Unknown | Adherence to Low Tidal Volume in the Transition to Spontaneous Ventilation in Patients With Acute Respiratory NCT06042036 | University of Sao Paulo General Hospital | — |
| Completed | Ventilatory Variables in Subjects With Acute Respiratory Distress Syndrome Due to COVID-19 NCT05946525 | Hospital Donación Francisco Santojanni | — |
| Recruiting | Visualization of Inspiratory Effort and Respiratory Mechanics to Promote Lung- and Diaphragm Protective Ventil NCT05459116 | University Hospital, Antwerp | N/A |
| Recruiting | Telehealth-Enabled, Real-time Audit and Feedback for Clinician AdHerence (TEACH) NCT05141396 | Intermountain Health Care, Inc. | N/A |
| Completed | Time Course of Neuro-ventilatory Efficiency During a Spontaneous Breathing Training NCT05380687 | University Hospital, Antwerp | N/A |
| Completed | Flow-controlled Ventilation (FCV) in Moderate Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19 NCT04894214 | University Hospital, Antwerp | — |
| Completed | Quality of Life in Ventilator-dependant Neuromuscular Patients NCT04652401 | Centre d'Investigation Clinique et Technologique 805 | — |
| Unknown | Effectiveness of Musicotherapy in Weaning From Mechanical Ventilation NCT04602182 | Basque Health Service | N/A |
| Unknown | Pediatric Ventilation Weaning NCT04023643 | São Paulo State University | N/A |
| Unknown | Effect of PEEP=5cmH2O vs PEEP=0cmH2O PSV Strategies During SBT on Successful Disconnection From Mechanical Ven NCT04939285 | First Affiliated Hospital, Sun Yat-Sen University | N/A |
| Completed | Characteristics of Weaning From Mechanical Ventilation in COVID-19 NCT05049200 | Sanatorio Anchorena San Martin | — |
| Completed | Flow Controlled Ventilation in Cardiac Surgery NCT04306757 | Medical University Innsbruck | N/A |
| Completed | Impact of Decreasing Respiratory Rate on Lung Injury Biomarkers in ARDS Patients NCT04641897 | Pontificia Universidad Catolica de Chile | N/A |
| Completed | Healthcare-associated Infections in Severe COVID-19 During 2020 NCT04819165 | Sanatorio Anchorena San Martin | — |
| Unknown | Conservative Versus Conventional Oxygen Administration in Critically Ill Patients NCT04198077 | University of Modena and Reggio Emilia | Phase 4 |
| Completed | Ventilatory Weaning Guided by a New Index NCT04512677 | Universidade Federal Fluminense | N/A |
| Unknown | Continuous Evaluation of Diaphragm Function NCT03941002 | University of Milan | N/A |
| Completed | Mechanical Ventilation Epidemiology in Argentina. NCT04107467 | Argentinian Intensive Care Society | — |
| Completed | PEEP-induced Changed in RRI as Physiological Background of Ventilator-induced Kidney Injury NCT03969914 | Università degli Studi di Ferrara | — |
| Completed | Improvement of Weaning From Mechanical Ventilation by Continuous Ultrasound Monitoring of Diaphragm Excursion NCT04008875 | Respinor AS | — |
| Completed | Continuous Measurement of Diaphragm Excursion as a Predictor of Extubation Failure NCT03896048 | Respinor AS | — |
| Unknown | A SBT-based Protocol-directed Program in Difficult-to-Wean Patients NCT05035355 | JinyanXing | N/A |
| Completed | Fluid Responsiveness Predicted by a Stepwise PEEP Elevation Recruitment Maneuver in Mechanically Ventilated Pa NCT04304521 | Centre Hospitalier Universitaire de Saint Etienne | — |
| Unknown | Hemodynamic Effects of Ventilation Modes NCT03684291 | Ufuk University | — |
| Unknown | Weaning Algorithm for Mechanical VEntilation NCT03697785 | Royal Brompton & Harefield NHS Foundation Trust | N/A |
| Completed | Aerosol Therapy in Intensive Care Units NCT03597334 | lvshan | — |
| Completed | Diaphragm Protective Ventilation in the Intensive Care Unit NCT03527797 | Amsterdam UMC, location VUmc | N/A |
| Completed | Transpulmonary Driving Pressure and Intra-abdominal Pressure Relationship During Laparoscopic Surgery NCT03435913 | Hospital Universitario La Fe | N/A |
| Completed | Adherence to LPV in SICU and Associated Clinical Outcomes NCT03698799 | Mahidol University | — |
| Recruiting | KAP Asynchrony Survey NCT03439683 | University of Sao Paulo General Hospital | — |
| Unknown | Organ Donation Survey Among Health Care Professionals in Argentina NCT03458052 | Hospital Italiano de Buenos Aires | — |
| Unknown | Mitral Doppler as a Predictor of Respiratory Worsening After Vascular Filling NCT03447366 | Centre Hospitalier Metropole Savoie | N/A |
| Unknown | Weaning From Mechanical Ventilation Comparison of Open-loop Decision Support System and Routine Care NCT02842944 | Centre Hospitalier Universitaire, Amiens | N/A |
| Completed | WOB and Paediatric Mechanical Ventilation NCT05254691 | University Medical Center Groningen | N/A |
| Unknown | Ventilation in Cardiac Surgery NCT03255356 | University Hospital, Caen | — |
| Completed | Study of the Combined Influence of Sepsis and Mechanical Ventilation on the Human Diaphragm NCT03371602 | Hospices Civils de Lyon | N/A |
| Completed | Impact of Lung Recruitment Maneuvers on Driving Pressure in Cardiac Surgery NCT03976947 | University Hospital, Caen | — |
| Terminated | Breath Synchronized Abdominal Muscle Stimulation to Facilitate Ventilator Weaning: a Pilot Study NCT03019107 | Liberate Medical | — |
| Unknown | Sedation Administration Timing: Intermittent Dosing Reduces Time to Extubation NCT03181620 | Abington Memorial Hospital | N/A |
| Completed | Influence of Chronic Vascular Diseases on Transcranial Doppler Profiles in Critically Ill Patients NCT02898389 | Centre Hospitalier Universitaire de Nīmes | — |
| Completed | Impact of Draining Significant Effusion on Gas Exchange and Lung Mechanics in Patient Under Mechanical Ventila NCT03394872 | Dokuz Eylul University | — |
| Unknown | Are Medical Personnel Can Correctly Recognize the Chest Sounds? NCT02703285 | Medical University of Warsaw | N/A |
| Completed | Use of a New Isokinetic Device for Inspiratory Muscle Training NCT02932189 | Universidade Federal Fluminense | N/A |
| Completed | Practice of Mechanical Ventilation in Patients With Severe Brain Injury in China NCT02517073 | Capital Medical University | — |
| Completed | Initiation of Home Mechanical Ventilation at Home in Patients With Chronic Hypercapnic Respiratory Failure NCT03203577 | University Medical Center Groningen | N/A |
| Completed | Ultrasound to Evaluate Failure of Liberation From Mechanical Ventilation NCT02723565 | University Health Network, Toronto | — |
| Completed | Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Mechanical Ventil NCT01967680 | Palle Toft | N/A |
| Completed | Electrical Stimulation of the Quadriceps and Diaphragm in Critically Ill Patients NCT03352102 | Pericles Almeida Delfino Duarte | N/A |
| Completed | The Correlational Study of PPV in Various VT in Mechanically Ventilated Patients NCT01950949 | Yi Liu | N/A |
| Completed | Development of a Rehabilitation Strengthening and Mobility Program for Ventilator Dependent Older Patients NCT03195127 | University of Maryland, Baltimore | N/A |
| Completed | Fluid Leakage Past Tracheal Tube Cuff : Effect of Suctioning Manoeuvre NCT01170156 | Centre Hospitalier de Roanne | N/A |
| Terminated | Effect of Bispectral Index (BIS) Titrated Propofol Sedation on Lower Esophageal Sphincter Pressures and Esopha NCT01173263 | The Cleveland Clinic | N/A |
| Unknown | Patient-ventilator Asynchrony During Mechanical Invasive Assisted-ventilation in Pediatric Patients NCT01193023 | University Hospital, Geneva | N/A |
| Completed | Proportional Assisted Ventilation and Pressure Support Ventilation in Adult Patients With Prolonged Ventilatio NCT04140682 | Kaohsiung Veterans General Hospital. | N/A |
| Completed | Adjunctive Clonidine in the Sedation of Mechanically Ventilated Children NCT00959062 | Hamilton Health Sciences Corporation | Phase 4 |
| Unknown | Adaptive Support Ventilation in Acute Respiratory Distress Syndrome (ARDS) NCT01165528 | Post Graduate Institute of Medical Education and Research, Chandigarh | N/A |
| Withdrawn | Pilot Study Evaluating Stress Response and Immune Function in Mechanically Ventilated Patients With Alcohol Us NCT00871039 | Virginia Commonwealth University | Phase 4 |
| Terminated | Proportional Assist Ventilation vs Pressure Support Ventilation NCT00790725 | Massachusetts General Hospital | N/A |
| Completed | Pressure Support During Chest Wall Compression NCT01155648 | Hospital de Clinicas de Porto Alegre | N/A |
| Unknown | Pressure Support Reduction Versus Spontaneous Breathing Trials in Weaning From Ventilation NCT00911378 | Post Graduate Institute of Medical Education and Research, Chandigarh | N/A |
| Completed | Effects of Remifentanil on Respiratory Function in Mechanically Ventilated Patients NCT00665119 | Fondazione Poliambulanza Istituto Ospedaliero | Phase 4 |
| Withdrawn | Use of NAVA in Intubated Preterm NCT00536445 | Sunnybrook Health Sciences Centre | Phase 1 / Phase 2 |
| Withdrawn | Evaluation of the Versamed iVent in the Transport of Patients Receiving Mechanical Ventilation NCT00652756 | Tufts Medical Center | N/A |
| Completed | Advantages and Disadvantages of Long Term Sedation in Intensive Care Unit Patients NCT00466492 | Odense University Hospital | N/A |
| Completed | Effects of Sternal Wall Pressure in Children NCT00628407 | Children's Hospital of Philadelphia | — |
| Terminated | Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms NCT00409344 | Massachusetts General Hospital | Phase 4 |
| Completed | Feasibility of Ventilation Detection Via Standard Defibrillator Pads in Mechanically Ventilated Pediatric Pati NCT00628875 | Children's Hospital of Philadelphia | — |
| Completed | Effects Of Invasive And Noninvasive Mechanical Ventilation On Sleep In The Intensive Care Unit (ICU) NCT00638339 | Tufts Medical Center | — |
| Terminated | Weaning From Mechanical Ventilation Using Permissive Hypercarbia NCT00357929 | Milton S. Hershey Medical Center | N/A |
| Completed | Safety and Efficacy of Emergency On-call Respiratory Physiotherapy Services in the Paediatric Intensive Care U NCT01999426 | Great Ormond Street Hospital for Children NHS Foundation Trust | N/A |
| Completed | 24-Hour NAVA Ventilation in Acute Respiratory Failure NCT00583037 | Unity Health Toronto | N/A |
| Completed | Energy Expenditure in Weaning From Mechanical Ventilation NCT00853060 | Hospital de Clinicas de Porto Alegre | — |
| Completed | GPI 15715 For Sedation in the Intensive Care Unit (ICU) Setting NCT00125398 | Eisai Inc. | Phase 2 |
| Completed | Medical Gas Humidification During Noninvasive Mechanical Ventilation NCT00124345 | Policlinico Hospital | N/A |
| Completed | A Comparison of Dexmedetomidine and Haloperidol in Patients With Intensive Care Unit (ICU)-Associated Agitatio NCT00505804 | Austin Health | Phase 2 |
| Completed | Two Cycling Off Modes in Pressure Support: Study of Respiratory Mechanics, Breathing Comfort and Asynchrony Pa NCT00910286 | Hospital de Clinicas de Porto Alegre | N/A |
| Unknown | Impact of Heparin on the Need for Mechanical Ventilation in Neonates NCT00196469 | University Medicine Greifswald | Phase 4 |
| Completed | ABC Trial: Awakening and Breathing Controlled NCT00097630 | National Institute on Aging (NIA) | N/A |
| Completed | A Cluster Randomized Trial to Improve Weaning and Extubation From Mechanical Ventilation in Community Hospital NCT00157287 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Phase 3 |
| Completed | Vitamin A Supplementation for Extremely-Low-Birth-Weight Infants NCT01203488 | NICHD Neonatal Research Network | Phase 1 / Phase 2 |
| Recruiting | Analysis of the Evolution of Mortality in an Intensive Care Unit NCT05261607 | Hospital Universitario Getafe | — |
| Completed | Tracheobronchial Secretion Removal NCT00932776 | University of Milano Bicocca | N/A |