NCT00466492

Advantages and Disadvantages of Long Term Sedation in Intensive Care Unit Patients

Advantages and Disadvantages of Long Term Sedation in ICU Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 140 (actual)
• Sponsor: Odense University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to determine whether sedation of the critical ill patient prolongs the time receiving mechanical ventilation.

Detailed description

The golden standard is to sedate critical ill patients receiving mechanical ventilation with daily wake up trials. This is shown to reduce the time receiving mechanical ventilation compared to no wake up trials. We would like to study whether no sedation but only analgesics administered as bolus doses, reduce the time receiving mechanical ventilation. The study is planned as a randomised prospective study, not blinded. The control group is patients receiving sedation with daily wake up trials. The intervention group is not sedated, but receives bolus doses of analgesics (morphine). The endpoint is the time spend receiving mechanical ventilation, lengths of stay on the intensive care unit, and total lengths of stay on the hospital. We also examine the frequency of ventilator associated pneumonia and CT scans of cerebrum. Also we would like to examine the long term psychological effects of sedation, we plan to send some of the patients to a post traumatic stress screening. The effect on the next of kin we plan to study with a questionnaire. As a last thing we would like to study the workload on the nurses.

Conditions

• Critical Illness
• Length of Stay
• Respiration, Artificial
• Intensive Care Units

Interventions

Type	Name	Description
PROCEDURE	Sedation or no sedation during mechanical ventilation	No sedation to critically ill patients

Timeline

• Start date: 2007-04-01
• Primary completion: 2009-05-01
• Completion: 2009-05-01
• First posted: 2007-04-27
• Last updated: 2010-03-19

Locations

1 site across 1 country: Denmark