Trials / Completed
CompletedNCT03371602
Study of the Combined Influence of Sepsis and Mechanical Ventilation on the Human Diaphragm
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 33 (actual)
- Sponsor
- Hospices Civils de Lyon · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The aim of this study is to study the combined impact of mechanical ventilation and sepsis on the human diaphragm in order to establish the neutral, protective or destructive character of mechanical ventilation by studying the diameter of the fibers, activation of proteolytic systems, inhibition of protein synthesis, tissue inflammation as well as contractile function.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | surgery | a diaphragmatic biopsy (100 microgram) and a parietal biopsy will be performed by the surgeon during surgery. |
| PROCEDURE | multi-organ sampling | a diaphragmatic biopsy (100 microgram) will be performed by the surgeon during surgery. |
Timeline
- Start date
- 2017-06-16
- Primary completion
- 2021-07-17
- Completion
- 2021-07-17
- First posted
- 2017-12-13
- Last updated
- 2023-07-07
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT03371602. Inclusion in this directory is not an endorsement.