Opioid Dependence

159 registered clinical trials studyying Opioid Dependence — 13 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	VK4-116 Phase I Study With Food-Effect NCT06808932	National Institute on Drug Abuse (NIDA)	Phase 1
Not Yet Recruiting	Assessing the Acceptability, Feasibility, Effectiveness and Cost-effectiveness of LADB NCT06129916	PATH	—
Recruiting	Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medication NCT05585229	University of British Columbia	Phase 2
Recruiting	Better Options for Chronic Cancer Pain NCT06574009	VA Office of Research and Development	Phase 4
Recruiting	Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery NCT06949826	Jenna-Leigh Wilson	Phase 4
Recruiting	The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opio NCT06837662	Oregon Health and Science University	N/A
Recruiting	fMRI and Opioid Abstinence NCT06651333	Yale University	—
Recruiting	A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy NCT05620940	Inventage Lab., Inc.	Phase 1
Not Yet Recruiting	Gut Microbiota Dysbiosis in Opioid Use Disorders: Implications for Clinical Symptoms and Relapse Rate. NCT06231849	Assiut University	—
Unknown	A Project to Test the Efficacy and Safety of An Innovative Treatment for Opiate Use Disorders. NCT05995873	MindLight, LLC	N/A
Recruiting	DE-eSCALation of Opioids Post-surgical dischargE NCT06396663	University of Kent	N/A
Withdrawn	OLP to Manage Pain in TJA: A Feasibility Study NCT04883983	University of Alabama at Birmingham	EARLY_Phase 1
Unknown	Exploratory Dose Ranging Study Assessing APH-1501 for the Treatment of Opioid Addiction NCT03813095	Aphios	Phase 2
Suspended	Measuring Acute Drug Demand in Humans NCT05829655	University of Maryland, Baltimore	EARLY_Phase 1
Terminated	The Effects of Daily Anti-inflammatory Supplementation on Foundation Pain Index Scores in Chronic Opiate Patie NCT05896878	Hudson Medical	N/A
Recruiting	STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancrea NCT05603702	Indiana University	Phase 1
Terminated	Novel Induction to Buprenorphine/Naloxone NCT05644587	Bicycle Health	Phase 4
Unknown	Effects on Mortality and Clinical Course of a Patient's Choice Model for Opioid Maintenance Treatment for Opio NCT05678036	Region Skane	—
Terminated	Brain Mechanisms of Pharmacotherapy in Opioid Use Disorder NCT04454411	University of Pennsylvania	Phase 2
Unknown	Return to Work - Will Brief Intervention Reduce Opioid-induced Back Pain? NCT05437861	University Hospital, Akershus	N/A
Completed	Feasibility and Preliminary Efficacy of an Opioid Stewardship Program in Hospitalized Patients With Chronic Pa NCT05370326	Yale University	N/A
Withdrawn	Can Simplified and More Detailed Instructions Affect Post-Operative Narcotic Consumption NCT03534102	Brigham and Women's Hospital	Phase 4
Completed	Efficiency And Quality In Post-Surgical Pain Therapy After Discharge NCT05221866	University of Nebraska	N/A
Completed	Friendship Bench Adaptation to Improve Mental Health & HIV Care Engagement Outcomes Among PLWH and PWID in Vie NCT04790201	University of North Carolina, Chapel Hill	N/A
Unknown	Prevention of Opioid Use Disorder After Surgery NCT04394559	Brigham and Women's Hospital	N/A
Active Not Recruiting	Comparing Home, Office, and Telehealth Induction for Medication Assisted Treatment for Opioid Use Disorder NCT04664062	University of Colorado, Denver	N/A
Unknown	Impact of a Behavioral Tele-health Program on the Quality of Recovery for Patients Undergoing Total Joint Repl NCT05367050	Lucid Lane, Inc	N/A
Recruiting	Young Houston Emergency Opioid Engagement System NCT04811014	The University of Texas Health Science Center, Houston	Phase 4
Completed	Comparing Two Training Methods for Opioid Wizard NCT04867382	HealthPartners Institute	N/A
Completed	HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysis NCT04571619	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Phase 2
Active Not Recruiting	Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure NCT05463367	Northwestern University	Phase 2
Unknown	Healthy Adult Male Facial Skin Surface Lipid Pheromone p.o. to Treat Opioid Addiction NCT03394911	Bubba Nicholson	Phase 3
Completed	An Innovative Intervention for OUD Treatment NCT04325659	Johns Hopkins University	Phase 2 / Phase 3
Completed	Preliminary Efficacy and Safety of Ibogaine in the Treatment of Methadone Detoxification NCT04003948	International Center for Ethnobotanical Education, Research, and Service	Phase 2
Terminated	Collaborative Care for Opioid Dependence And Pain Pilot Study NCT04121546	Indiana University	N/A
Completed	SMART Effectiveness Trial NCT04464421	Karen Derefinko, PhD	N/A
Completed	INDV-2000 First in Human NCT04413552	Indivior Inc.	Phase 1
Unknown	Intervening With Opioid-Dependent MothersMothers and Infants NCT04454645	University of Delaware	N/A
Terminated	The Analgesic Efficacy of Continuous Sub-fascial Bupivacaine Infusion and Lidocaine Patches in Post-cesarean P NCT04033562	WellSpan Health	Phase 4
Completed	Evaluation of Pain Neuroscience Education for Patients Who Experience Chronic Pain With Concurrent Opioid Depe NCT06442306	Wichita State University	N/A
Terminated	Perioperative Ketamine in Opioid-Tolerant Patients Undergoing Lumbar Spine Surgery NCT04220489	Jacques E. Chelly	Phase 2
Completed	Efficacy And Safety Of An Innovative Treatment Of Opiate Use Disorders NCT04340622	MindLight, LLC	N/A
Completed	Re-entry XR-NTX for Rural Individuals With Opioid Use Disorder NCT03447743	Michele Staton	EARLY_Phase 1
Unknown	Does Early Administration of Ultrasound Guided Regional Anesthesia for Long Bone Fractures Effect Long Term Pa NCT04189523	Wayne State University	N/A
Recruiting	Neuromodulation and Cognitive Training in Opioid Use Disorder NCT03773523	University of Minnesota	N/A
Completed	Medical Management of Sleep Disturbance During Opioid Tapering NCT03789214	Johns Hopkins University	Phase 2
Unknown	Utilizing Helpline for Opioid Dependence Treatment NCT03969238	University of Virginia	—
Completed	XRB vs. SLB in Jail and at Re-entry: Pilot, Proof of Concept NCT03604159	NYU Langone Health	Phase 4
Terminated	A Multimodal Enhanced Recovery Program in Anorectal Surgery NCT03992079	Columbia University	N/A
Completed	tDCS to Decrease Opioid Relapse (UG3) NCT03842137	Butler Hospital	N/A
Unknown	Community Studies of Long Acting Buprenorphine (CoLAB) NCT03809143	The University of New South Wales	Phase 3
Completed	Treatment of Opioid Use: Medication Adherence Therapy NCT03567356	Potomac Health Foundations	N/A
Terminated	Reducing the Abuse of Opioids in Drug Users NCT03837860	The University of Texas Health Science Center at San Antonio	EARLY_Phase 1
Completed	Remote Observed Dosing of Suboxone to Improve Clinical Practice NCT03769025	University of Pennsylvania	Phase 1 / Phase 2
Withdrawn	Needle-X: Usability Testing of a Smartphone Application NCT03665298	NYU Langone Health	N/A
Completed	A Pragmatic Trial of the Consult for Addiction Treatment and Care in Hospitals (CATCH) Model for Engaging Pati NCT03611335	NYU Langone Health	—
Completed	The Navigator Trial NCT03684681	Rhode Island Hospital	N/A
Unknown	Reducing Opioid Use for Chronic Pain Patients Following Surgery NCT03675386	University Health Network, Toronto	N/A
Unknown	A Study of Thienorphine Hydrochloride Tablets in Relapse Prevention Treatment of Opioid Dependence NCT03656120	Wei Hao	Phase 2
Completed	A Randomized, Double-Blind, Single-Center Clinical Study on the Efficacy of Naltrexone Implant in Antagonizing NCT07014644	Shenzhen Sciencare Medical Industries Co., Ltd.	Phase 2
Completed	Gabapentin Regimens and Their Effects on Opioid Consumption NCT03334903	Brigham and Women's Hospital	Phase 4
Completed	PG and PK of Oxycodone to Personalize Post-op Pain Management Following Surgery in Children NCT03495388	Senthil Sadhasivam	—
Completed	The Impact of Methadone Maintenance Therapy on Food Reward Processing in Opioid Dependence NCT03575273	Johns Hopkins University	N/A
Unknown	Switch to Genvoya Followed by HCV Therapy With Epclusa Followed by Simplification of HIV Therapy With Biktarvy NCT03549312	Saskatchewan Health Authority - Regina Area	Phase 4
Suspended	Physical Activity as Adjunct Treatment for Opioid Substitution Therapy NCT04496934	Haukeland University Hospital	N/A
Withdrawn	Safe Return and Disposal of Unused Opioids NCT03352479	Baylor College of Medicine	N/A
Active Not Recruiting	Facilitating Rapid Naltrexone Initiation NCT03345173	New York State Psychiatric Institute	Phase 3
Completed	Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures NCT03305666	Denver Health and Hospital Authority	Phase 4
Withdrawn	Naloxone to TReatment Entry in the Emergency Setting NCT03368794	Anders C Håkansson	N/A
Completed	Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings NCT03089983	Yale University	N/A
Completed	Meditation and Opioid Consumption in Total Joint Replacement Patients Undergo Primary Total Hip and Knee Repla NCT05669066	Beth Israel Deaconess Medical Center	N/A
Completed	The Life STORRIED Study NCT03134092	University of Pennsylvania	N/A
Completed	Comparing Opium Tincture (OT) With Methadone for Medication-assisted Treatment of Opioid Use Disorder NCT02502175	University of British Columbia	Phase 3
Completed	Developing rTMS Treatment Strategies for Pain in Opiate Dependence NCT03576781	Medical University of South Carolina	EARLY_Phase 1
Unknown	Liposomal Bupivacaine for Pain Control Following Thoracic Surgery. NCT03036085	Massachusetts General Hospital	Phase 2 / Phase 3
Completed	Drug Interaction and Subjective Effects of Compounds for Opioid Use Disorder NCT03143855	Virginia Commonwealth University	Phase 1
Terminated	Effects of Glucocorticoids on Craving During Detoxification Treatment of Heroin and/or Stimulants NCT02935101	Prof. Dominique de Quervain, MD	Phase 2
Unknown	Probuphine Innovations for Clinical Effectiveness (PRINCE) NCT02896660	Healthcare Innovation Technology Lab	N/A
Completed	Using Artificial Intelligence To Monitor Medication Adherence in Opioid Replacement Therapy NCT02243670	AiCure	N/A
Completed	Change the Cycle: An RCT to Prevent Injection Initiation NCT02774954	University of Southern California	N/A
Completed	A Naturalistic Study of Adolescents and Young Adults in Treatment for Opioid Dependence NCT02718352	Yale University	—
Completed	Comparing Interventions for Opioid Dependent Patients Presenting in Medical Emergency Departments NCT02586896	NYU Langone Health	N/A
Completed	Oxytocin Treatment of Opioid Dependence NCT02548728	University of North Carolina, Chapel Hill	Phase 1 / Phase 2
Completed	Medication-Assisted Treatment for Youth With Substance Use Disorders NCT02593474	New York State Psychiatric Institute	Phase 1
Completed	Improving Effective Contraceptive Use Among Opioid-maintained Women: Stage II NCT02411357	University of Vermont	N/A
Completed	The Effects of Minocycline in Opioid-maintained Patients NCT02359006	Yale University	N/A
Completed	Buprenorphine Treatment for Opioid Dependence NCT02187198	Yale University	Phase 3
Unknown	Study of Integrating Antiretroviral Therapy With Methadone Treatment for People Who Inject Drugs NCT02167425	Pangaea Global AIDS Foundation	—
Completed	Treatment Seeking Participants With Opioid Use Disorders Assessing Tolerability of Depot Injections of Bupreno NCT02357901	Indivior Inc.	Phase 3
Completed	Glutamatergic Modulation to Facilitate Naltrexone Initiation in Opioid Dependence NCT02437344	New York State Psychiatric Institute	Phase 2
Completed	Phone Interview to Prevent Recurring Opioid Overdoses NCT02282306	University of Cincinnati	N/A
Completed	Buprenorphine/Naloxone Stabilization and Induction Onto Injection Naltrexone NCT02294253	New York State Psychiatric Institute	Phase 2 / Phase 3
Completed	Desvenlafaxine in Opioid-Dependent Patients NCT02200406	Centre hospitalier de l'Université de Montréal (CHUM)	Phase 4
Completed	A Study of Adult Outpatients With Opioid Dependence Transitioned From a Daily SL Buprenorphine to Probuphine® NCT02180659	Titan Pharmaceuticals	Phase 3
Completed	Increasing Patient Knowledge of the Signs of Opioid Overdose and Naloxone in a Suburban Treatment Program NCT02120612	Edward Hospital	—
Completed	Using mHealth to Aid Opioid Medication Adherence Pilot Study NCT02017041	Care Team Solutions	—
Completed	Usability of Zubsolv Sublingual Tablets 5.7/1.4 to Suboxone Sublingual Film 8/2 In Buprenorphine/Naloxone Trea NCT02038790	Indivior Inc.	Phase 4
Completed	Improving Buprenorphine Detoxification Outcomes With Isradipine NCT01895270	University of Arkansas	Phase 1 / Phase 2
Completed	Study of the Treatment of Experimental Pain in Opioid Dependent Persons on Methadone or Buprenorphine Maintena NCT01642030	Johns Hopkins University	Phase 1
Completed	Efficacy, Safety and Dose-Response Study Followed by Open-Label Study of Lofexidine Treatment of Opioid Withdr NCT01863186	USWM, LLC (dba US WorldMeds)	Phase 3
Completed	A Randomized, 4-sequence, 2-period, Double-blind, Placebo Controlled Study With a DSM-IV-TR Diagnosis of Cocai NCT01846481	Indivior Inc.	Phase 2
Completed	Dane County Drug Court Study for Addicted Offenders NCT01843751	University of Wisconsin, Madison	Phase 3
Completed	Pharmacokinetic & Pharmacodynamic Interaction of Lofexidine and Buprenorphine in Buprenorphine Maintained Pati NCT01820442	USWM, LLC (dba US WorldMeds)	Phase 1
Completed	Pilot Test of a Community-based Buprenorphine Treatment Intervention NCT01761110	Albert Einstein College of Medicine	N/A
Completed	Effects of Ibudilast on Oxycodone Self-administration in Opioid Abusers NCT01740414	New York State Psychiatric Institute	Phase 2
Completed	Acute Effects of Cortisol on Heroin Craving in Opioid Dependence (Ghost-Basel) NCT01718964	Prof. Dominique de Quervain, MD	Phase 2
Completed	Naltrexone vs Buprenorphine-Naloxone for Opioid Dependence in Norway NCT01717963	University of Oslo	Phase 3
Completed	An Open Label Study To Assess The Safety And Tolerability Of BEMA® Buprenorphine NX In Opioid Dependent Subjec NCT01666119	BioDelivery Sciences International	Phase 2
Completed	Main Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients NCT01650649	USWM, LLC (dba US WorldMeds)	Phase 1
Completed	Methadone Oxytocin Option NCT01728909	University of California, San Francisco	EARLY_Phase 1
Completed	The Separate and Combined Effects of Vivitrol and Opiate Abstinence Reinforcement in the Treatment of Opioid D NCT01556425	Johns Hopkins University	Phase 2
Completed	Computer-based Cognitive Behavioral Therapy for Risky Behaviors in Opioid Dependent Patients NCT01645033	Yale University	N/A
Completed	Distress Tolerance and Buprenorphine NCT01556087	Butler Hospital	Phase 3
Completed	Pilot Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients NCT01558934	USWM, LLC (dba US WorldMeds)	Phase 1
Unknown	An Assessment of Fentanyl Dose Requirements in Opioid-maintained Individuals NCT01358500	University of Adelaide	N/A
Completed	Aprepitant Effects in Intravenous Heroin Dependence NCT01527994	NYU Langone Health	Phase 1
Completed	Study to Assess Longer-term Opioid Medication Effectiveness (SALOME) NCT01447212	University of British Columbia	Phase 3
Completed	Biomarkers of Injectable Extended Release Naltrexone Treatment NCT02324725	University of Pennsylvania	Phase 4
Completed	Improving Effective Contraceptive Use Among Opioid-maintained Women NCT01425060	University of Vermont	Phase 1
Completed	ALK21-025: Vivitrol's Cost and Treatment Outcomes Registry NCT01422837	Alkermes, Inc.	—
Completed	Completion of OST - a Prospective Study NCT01722435	Universitätsklinikum Hamburg-Eppendorf	—
Completed	Pilot Study of Varenicline to Treat Opioid Dependence NCT01436474	Mayo Clinic	Phase 1
Completed	Improved Strategies for Outpatient Opioid Detoxification NCT01377610	New York State Psychiatric Institute	Phase 1
Completed	Naltrexone for Opioid Dependent Released Human Immunodeficiency Virus Positive (HIV+) Criminal Justice Populat NCT01246401	Yale University	Phase 1 / Phase 2
Completed	KCNH2 Polymorphisms on the QTc Interval in Kelantanese Malays Patients Receiving Methadone Maintenance Therapy NCT03603158	Universiti Sains Malaysia	—
Completed	A Study of VIVITROL in the Prevention of Re-arrest and Re-incarceration NCT01453374	Alkermes, Inc.	Phase 4
Completed	Medications Development for Drug Abuse Disorders NCT01188421	Johns Hopkins University	Phase 1 / Phase 2
Completed	Effects of Gabapentin Versus Placebo on Buprenorphine Detoxification of Opioid-dependent Individuals NCT01262092	University of Arkansas	Phase 2
Completed	Starting Treatment With Agonist Replacement Therapies Follow-up Study NCT01592461	University of California, Los Angeles	—
Completed	A Within Subject Comparison of Opioid Withdrawal in Opioid Dependent Individuals NCT01136356	Johns Hopkins University	Phase 1 / Phase 2
Completed	Dronabinol Naltrexone Treatment for Opioid Dependence NCT01024335	New York State Psychiatric Institute	Phase 2 / Phase 3
Completed	Memantine-enhanced Buprenorphine Treatment for Opioid-dependent Young Adults NCT01052662	University of Massachusetts, Worcester	Phase 2 / Phase 3
Completed	Treatment for Opioid Dependent Offenders NCT01082679	University of Wisconsin, Madison	Phase 2 / Phase 3
Terminated	A Bioavailability and Safety Study of Probuphine Versus Sublingual Buprenorphine in Patients With Opioid Depen NCT00768482	Titan Pharmaceuticals	Phase 3
Completed	Drug Discrimination in Methadone-Maintained Humans Study 2 NCT00733239	University of Arkansas	Phase 1
Completed	The Prevalence of HIV Drug Resistance and Transmission Risk in Opioid Agonist Treatment NCT00857350	Yale University	—
Completed	Methadone Maintenance & HIV Risk in Ukraine NCT00351026	University of Pennsylvania	Phase 3
Completed	Memantine as a Supplement to Naltrexone in Treating Heroin Dependence NCT00476242	New York State Psychiatric Institute	Phase 2 / Phase 3
Completed	Relapse Prevention to Reduce HIV Among Women Prisoners NCT00763958	University of Alabama at Birmingham	Phase 4
Completed	Extension to Safety and Efficacy of Probuphine in the Treatment of Opioid Dependence NCT00630201	Titan Pharmaceuticals	Phase 3
Completed	Levetiracetam (Keppra) Tolerability in Cocaine Abusing Methadone-maintained Patients. NCT00593125	Yale University	Phase 2
Completed	Gabapentin Treatment of Benzodiazepine Abuse in Methadone Maintenance Patients NCT00420771	New York State Psychiatric Institute	Phase 2
Completed	Safety and Efficacy of Probuphine in the Treatment of Opioid Dependence NCT00447564	Titan Pharmaceuticals	Phase 3
Completed	Testing a Community-Friendly Risk Reduction Intervention for Injection Drug Users NCT01741350	University of Connecticut	N/A
Completed	Integrating Buprenorphine Into the SFGH AIDS Program NCT00263458	University of California, San Francisco	Phase 4
Completed	Prescription Opioid Abuse Among Pain Patients: Predictors of Relapse NCT01967641	New York State Psychiatric Institute	Phase 2
Completed	Depot Naltrexone Treatment of Opioid Dependent Parolees NCT00756990	University of Pennsylvania	N/A
Completed	FMRI of Stress and Addictive Disorders NCT01558973	Yale University	—
Completed	RCT Comparing Methadone and Buprenorphine in Pregnant Women NCT00271219	Johns Hopkins University	Phase 3
Completed	Memantine and Naltrexone Treatment for Opioid Dependence NCT00125515	New York State Psychiatric Institute	Phase 2
Completed	Pharmacogenetics of Disulfiram for Cocaine NCT00149630	Baylor College of Medicine	Phase 2
Completed	The German Project of Heroin Assisted Treatment of Opiate Dependent Patients NCT00268814	Universitätsklinikum Hamburg-Eppendorf	Phase 3
Completed	Buprenorphine/Naloxone in the Treatment of Heroin Dependence - 14 NCT00015340	National Institute on Drug Abuse (NIDA)	Phase 4
Completed	Combined Behavioral and Pharmacologic Treatment of Polydrug Abuse NCT00292123	National Institute on Drug Abuse (NIDA)	Phase 1
Completed	The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Coc NCT00158288	National Institute on Drug Abuse (NIDA)	Phase 2
Completed	Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 2 NCT00249457	Johns Hopkins University	N/A
Completed	Opioid Maintenance Medications Comparison Study NCT00344812	Johns Hopkins University	Phase 2
Withdrawn	Evaluation of BEMA® Buprenorphine NX for Buprenorphine Induction of Opioid Dependent Subjects NCT01713803	BioDelivery Sciences International	Phase 3
Withdrawn	The Safety of Using Buprenorphine With Naloxone in a Buccal Film to Initiate Treatment of Opioid Dependent Sub NCT02516436	BioDelivery Sciences International	Phase 3