NCT01728909

Methadone Oxytocin Option

The Effects of Intranasal Oxytocin on Social Cognition and Social Approach Behaviors in Opioid-dependent Patients

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 64 (actual)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of the study is to examine the effects of intranasal oxytocin administration on social cognition in patients receiving methadone maintenance treatment (MMT), examine the effects of intranasal oxytocin administration on opioid craving and on the subjective effects of methadone, and examine the effects of intranasal oxytocin administration on implicit preferences for drug-related and social stimuli in patients receiving MMT. Hypothesis 1: Patients will perform better on measures of social cognition (including affect recognition and recognition of sarcasm) after administration of oxytocin compared with placebo. Hypothesis 2: Patients will demonstrate lower craving for opioids and greater subjective effects of methadone after administration of oxytocin compared with placebo. Hypothesis 3: Patients will demonstrate increased implicit preferences for social stimuli and decreased implicit preferences for drug related stimuli after administration of oxytocin compared with placebo.

Conditions

• Substance Abuse
• Opioid Dependence
• Methadone Treatment

Interventions

Type	Name	Description
DRUG	Oxytocin	40 IU of the oxytocin will be administered intranasally for a one time dose at the beginning of the visit.
DRUG	Saline Nasal Spray	40 IU of the saline nasal spray will be administered once at the beginning of the visit.

Timeline

• Start date: 2012-05-01
• Primary completion: 2014-10-01
• Completion: 2014-10-01
• First posted: 2012-11-20
• Last updated: 2019-05-21

Locations

1 site across 1 country: United States